{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:49:46Z","timestamp":1773409786315,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Syndromes involving peptide or nonsex steroid hormone secretion due to aberrantly located tumors are rare. We report a collected series of 16 patients with ectopic hormone production from ovarian neoplasms, including 3 patients recently encountered at our institution as well as 13 additional cases identified in the recent literature. These tumors included 2\u00a0insulin\u2010producing ovarian carcinoids, 1 ACTH\u2010producing pituitary adenoma within a benign ovarian cystic teratoma, 2 cortisol\u2010producing ovarian neoplasms, 8 gastrin\u2010producing ovarian cystadenomata or cystadenocarcinomata, and 3 thyroxine\u2010producing ovarian strumal carcinoids. All patients presented with syndromes of hormone excess. Only 62% of all tumors were localized preoperatively. Following ovarian resection, 87% of patients remained disease\u2010free with a median follow\u2010up period of 1.5 years. In addition to ovariectomy, 8 additional unnecessary ablative procedures were performed in 7 patients. These included distal pancreatectomy, pancreaticoduodenectomy, adrenalectomy, total gastrectomy, selective vagotomy, and subtotal thyroidectomy. Failure to localize the ovarian neoplasm preoperatively was associated with a significantly higher risk of subsequent unnecessary ablative procedures. Because of the potential for the ovary to act as a source of aberrant hormone secretion, we recommend complete preoperative evaluation of the pelvis in female patients presenting with nonlocalizable endocrine tumors<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01658520","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T13:03:12Z","timestamp":1115557392000},"page":"335-340","source":"Crossref","is-referenced-by-count":6,"title":["Aberrant hormone production from ovarian neoplasms: Strategies for diagnosis and therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Steven D.","family":"Leach","sequence":"first","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette I.","family":"LaMorte","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence D.","family":"True","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart D.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Elton","family":"Cahow","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara K.","family":"Kinder","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine 333 Cedar Street 06510 New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1990,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03720240063036"},{"key":"e_1_2_1_3_1","first-page":"509","article-title":"Preoperative localization and intraoperative glucose monitoring in the management of patients with pancreatic insulinoma","volume":"163","author":"Katz B.L.","year":"1986","journal-title":"Surg. Gynecol. 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