{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:52:52Z","timestamp":1790941972258,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Coincident with medical antitumor treatment of 138 patients suffering from mid\u2010gut carcinoid tumors, 51 patients were subjected to surgery with the principal aims of removing primary tumors and debulking mesenteric or liver metastases. Sixteen patients had previously been operated with intestinal resection or, when the tumors had been considered inexcisable, with intestinal bypass or laparotomy alone. Apart from exhibiting symptoms related to the carcinoid syndrome, the majority (approximately 60%) of the 51 patients had generally intermittent, subileus\u2010like abdominal pain and weight loss. In 18 patients, these symptoms were pronounced and associated with intestinal obstruction or severe malnutrition. Computed tomography and arteriography efficiently demonstrated mesenteric and liver metastases. At laparotomy, the primary intestinal tumors were small, mainly less than 1\u00a0cm in diameter, and they were multiple in 39% of the patients. Mesenteric metastases measuring up to 12\u00a0cm in diameter were present in 86% of the patients. These metastases were frequently associated with a pronounced mesenteric and retroperitoneal fibrosis causing fixation, angulation, and obstruction of the bowel as well as incipient intestinal gangrene in 8 patients. In all but 6 patients, the primary tumors could be removed by comparatively limited intestinal resections although bulky mesenteric metastases were often dissected from the mesenteric vessels. Liver metastases, found in 49% of the patients, were generally bilateral and multiple, and major hepatic metastases were resected in 6 patients. The results support a role for surgery also in the more compromised patients with mid\u2010gut carcinoid tumors and that such intervention may be associated with considerable symptomatic relief and substantial periods of survival<\/jats:bold>\n                    .\n                  <\/jats:p>","DOI":"10.1007\/bf01658532","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T09:03:12Z","timestamp":1115542992000},"page":"377-383","source":"Crossref","is-referenced-by-count":126,"title":["Surgical treatment of mid\u2010gut carcinoid tumors"],"prefix":"10.1002","volume":"14","author":[{"given":"Charlie","family":"Makridis","sequence":"first","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"\u00d6berg","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Rastad","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Johansson","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Erik","family":"L\u00f6relius","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Internal Medicine, and Diagnostic Radiology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2<560::AID-CNCR2820360235>3.0.CO;2-4"},{"key":"e_1_2_1_3_1","first-page":"1054","article-title":"Carcinoid tumors of the gastrointestinal tract: Presentation, management, and prognosis","volume":"98","author":"Thompson G.B.","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198708000-00001"},{"key":"e_1_2_1_5_1","first-page":"607","article-title":"Carcinoid tumors in the gastrointestinal tract\u2014An analysis of 156 cases","volume":"149","author":"M\u00e5rtensson H.","year":"1983","journal-title":"Acta Chir. 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