{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:44:52Z","timestamp":1765079092845},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1986,12,1]],"date-time":"1986-12-01T00:00:00Z","timestamp":533779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hourly measurements of bile acids, bacterial flora, and pH were made from gastric aspirates collected over 24 hours in subjects taking a controlled diet. Significantly higher concentrations of total bile acids were found following truncal vagotomy and antrectomy (TV+A), 2.73\u00b11.16 SEM mmol\/l, than after truncal vagotomy and pyloroplasty (TV+P), 0.88\u00b10.56\u00a0mmol\/l (<jats:italic>p&lt;0.002<\/jats:italic>), and controls, 0.43\u00b10.22\u00a0mmol\/l (<jats:italic>p&lt;0.002<\/jats:italic>). These observations were due to differences in nocturnal reflux only. Free secondary bile acids were identified more frequently after TV+A (19% of aspirates) than TV+P (6%) or controls (2%).<jats:italic>Streptococcus faecalis<\/jats:italic> and<jats:italic>Veillonella<\/jats:italic> spp, the principal organisms known to deconjugate and hydrolyze bile acids, were present in 65% of aspirates after TV+A compared with 35% after TV+P, and 33% of the controls. Mean pH values were 5.12 after TV+A, 2.82 after TV+P, and 2.14\u00a0in the controls. We conclude that antrectomy is associated with a greater incidence of duodenal reflux and a more suitable environment for the formation of secondary bile acids than vagotomy and pyloroplasty or in normal subjects.<\/jats:p>","DOI":"10.1007\/bf01658652","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T12:28:04Z","timestamp":1115555284000},"page":"981-987","source":"Crossref","is-referenced-by-count":5,"title":["Exposure to bile acids and bacteria over 24 hours following partial gastrectomy, vagotomy, and pyloroplasty"],"prefix":"10.1002","volume":"10","author":[{"given":"Valerie A.","family":"Poxon","sequence":"first","affiliation":[{"name":"Department of Surgery General Hospital Steelhouse Lane B4 6NH Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery General Hospital Steelhouse Lane B4 6NH Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise J.","family":"Youngs","sequence":"additional","affiliation":[{"name":"Department of Surgery General Hospital Steelhouse Lane B4 6NH Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen C.","family":"Albutt","sequence":"additional","affiliation":[{"name":"Department of Surgery General Hospital Steelhouse Lane B4 6NH Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Keighley","sequence":"additional","affiliation":[{"name":"Department of Surgery General Hospital Steelhouse Lane B4 6NH Birmingham UK"},{"name":"Department of Surgery University of Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197410000-00017"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90339-1"},{"key":"e_1_2_1_4_1","first-page":"419","article-title":"The significance of bile in reflux esophagitis","volume":"134","author":"Gillison E.W.","year":"1972","journal-title":"Surg. 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