{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:19:45Z","timestamp":1770502785784,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Twenty\u2010two cirrhotic patients with hepatocellular carcinoma (HCC) and concomitant esophageal varices underwent aggressive hepatic resection accompanied by simultaneous devascularization, perioperative endoscopic injection sclerotherapy, or both (group A). To evaluate this treatment, 37 cirrhotic patients without esophageal varices who underwent hepatic resection for small HCC (2\u00a0cm or less) during the same period (group B) were studied to compare clinical data, preoperative laboratory data, pathologic findings, disease\u2010free rates, and survival rates. The operative time, blood loss, and resected liver weight did not differ between the two groups; however, the tumor size of group A (2.7\u00b11.6\u00a0cm, mean\u00b1SD) was significantly larger than that of group B (1.5\u00b10.3\u00a0cm). The preoperative liver function of group A was also more severe than that of group B except for prothrombin time. Despite these disadvantages, the 1\u2010, 3\u2010, and 5\u2010year disease\u2010free rates of the two groups were 72% versus 94%, 48% versus 54%, and 38% versus 45%, respectively, and the 1\u2010, 3\u2010, and 5\u2010year survival rates were 91% versus 97%, 79% versus 79%, and 54% versus 67% (group A versus group B), respectively, which showed no significant differences. Furthermore, there was no variceal bleeding in group A after treatment. Based on the above findings, for treatment of HCC and concomitant esophageal varices, aggressive hepatic resection accompanied by simultaneous devascularization, perioperative endoscopic injection sclerotherapy, or both is the preferred form of treatment<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01658710","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T13:17:02Z","timestamp":1115558222000},"page":"398-402","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of early hepatocellular carcinoma and concomitant esophageal varices"],"prefix":"10.1002","volume":"17","author":[{"given":"Hidefumi","family":"Higashi","sequence":"first","affiliation":[{"name":"Department of Surgery II Faculty of Medicine Kyushu University 3\u20101\u20101\u00a0Maidashi, Higashi\u2010ku 812 Fukuoka Japan"},{"name":"Department of Surgery Iizuka Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsumata","sequence":"additional","affiliation":[{"name":"Department of Surgery II Faculty of Medicine Kyushu University 3\u20101\u20101\u00a0Maidashi, Higashi\u2010ku 812 Fukuoka Japan"},{"name":"Department of Surgery Iizuka Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Surgery II Faculty of Medicine Kyushu University 3\u20101\u20101\u00a0Maidashi, Higashi\u2010ku 812 Fukuoka Japan"},{"name":"Department of Surgery Iizuka Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Surgery II Faculty of Medicine Kyushu University 3\u20101\u20101\u00a0Maidashi, Higashi\u2010ku 812 Fukuoka Japan"},{"name":"Department of Surgery Iizuka Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Surgery II Faculty of Medicine Kyushu University 3\u20101\u20101\u00a0Maidashi, Higashi\u2010ku 812 Fukuoka Japan"},{"name":"Department of Surgery Iizuka Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Sugimachi","sequence":"additional","affiliation":[{"name":"Department of Surgery II Faculty of Medicine Kyushu University 3\u20101\u20101\u00a0Maidashi, Higashi\u2010ku 812 Fukuoka Japan"},{"name":"Department of Surgery Iizuka Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060432"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770629"},{"key":"e_1_2_1_4_1","first-page":"504","article-title":"Hepatoportal arteriovenous fistula in primary carcinoma of the liver","volume":"145","author":"Nagasue N.","year":"1977","journal-title":"Surg. 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