{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:17:36Z","timestamp":1777454256646,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this investigation was to assess the effects of preoperative administration of parenteral antibiotics with or without concomitant preoperative administration of oral antibiotics on the colonie mucosal\u2010related microflora. Thirty\u2010one patients were studied in a prospective fashion. Group A patients (n=8) had colonoscopic mucosal biopsies performed after mechanical bowel preparation. Group B patients (n=5) received neomycin and erythromycin (NE), 1 g each following mechanical bowel preparation, at 1,2, and 11 p.m. the evening prior to either elective colon resection (n=2) or prior to colonoscopic biopsy (n=3). Emergent trauma patients who had left colon or sigmoid perforations due to gunshot wounds requiring segmental resection comprised group C (n=7). These patients received cefoxitin or cefotetan 2 g intravenously preoperatively. Individuals in group D (n=11) all had elective left hemicolectomies or sigmoid resections due to nonobstructing malignancies. These patients underwent the same regimen as group B patients in addition to receiving intravenous cefoxitin perioperatively. Quantitative and qualitative bacterial cultures as well as scanning electron microscopy (SEM) were used to study the mucosa\u2010associated flora. Tissue for culture and SEM were obtained from the pathologic specimen immediately after removal. The interval between the dosage of parenteral antibiotics to tissue removal was 3 hours in both groups. Anaerobic and aerobic counts were suppressed the greatest in patients receiving both oral and parenteral antibiotics (<jats:italic>p<\/jats:italic>=0.0001). Mean anaerobic counts decreased from 3.4\u00d710<jats:sup>7<\/jats:sup> in group A to 1.8\u00d710<jats:sup>2<\/jats:sup> (mean cfu\/g) in group D patients. Mean aerobic counts in group A decreased from 3.7\u00d710<jats:sup>6<\/jats:sup> to 64 (mean cfu\/g) in group D. This study documents the effectiveness of oral NE to suppress the mucosa\u2010associated flora when administered preoperatively and suggests that parenteral antibiotics suppress the mucosa\u2010associated bacteria in addition to providing therapeutic serum levels.<\/jats:p>","DOI":"10.1007\/bf01658812","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T18:17:09Z","timestamp":1115576229000},"page":"636-641","source":"Crossref","is-referenced-by-count":18,"title":["Suppression of the human mucosal\u2010related colonic microflora with prophylactic parenteral and\/or oral antibiotics"],"prefix":"10.1002","volume":"14","author":[{"given":"Mark B.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Surgery Tulane University School of Medicine 1430 Tulane Ave. 70112 New Orleans Louisiana USA"},{"name":"Department of Anatomy Louisiana State University Medical School New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipool K.","family":"Goradia","sequence":"additional","affiliation":[{"name":"Department of Surgery Tulane University School of Medicine 1430 Tulane Ave. 70112 New Orleans Louisiana USA"},{"name":"Department of Anatomy Louisiana State University Medical School New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Surgery Tulane University School of Medicine 1430 Tulane Ave. 70112 New Orleans Louisiana USA"},{"name":"Department of Anatomy Louisiana State University Medical School New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel G.","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Department of Surgery Tulane University School of Medicine 1430 Tulane Ave. 70112 New Orleans Louisiana USA"},{"name":"Department of Anatomy Louisiana State University Medical School New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery Tulane University School of Medicine 1430 Tulane Ave. 70112 New Orleans Louisiana USA"},{"name":"Department of Anatomy Louisiana State University Medical School New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald Lee","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Surgery Tulane University School of Medicine 1430 Tulane Ave. 70112 New Orleans Louisiana USA"},{"name":"Department of Anatomy Louisiana State University Medical School New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1990,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800650902"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.43.6.1451-1463.1982"},{"key":"e_1_2_1_4_1","first-page":"145","volume-title":"Adsorption of Microorganisms to Surfaces","author":"Lee A.","year":"1980"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800670203"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410030027003"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.10.1.240-250.1974"},{"key":"e_1_2_1_8_1","first-page":"227","volume":"176","author":"Nichols R.L.","year":"1972","journal-title":"Efficacy of preoperative antimicrobial preparation of the bowel"},{"key":"e_1_2_1_9_1","first-page":"173","article-title":"Bactericidal efficacy of various bowel preparation techniques on the microflora of the colonic lumen and mucosa","volume":"39","author":"Lindsey J.T.","year":"1988","journal-title":"Surg. Forum."},{"key":"e_1_2_1_10_1","first-page":"70","article-title":"Reevaluation of the \u201cinstant\u201d colon preparation with povidone iodine","volume":"35","author":"Rotstein O.D.","year":"1985","journal-title":"Surg. Forum"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197310000-00008"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90097-8"},{"key":"e_1_2_1_13_1","first-page":"282","article-title":"Impromptu bowel cleansing and sterilization","volume":"43","author":"Gliedman M.L.","year":"1958","journal-title":"Surgery"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02560057"},{"key":"e_1_2_1_15_1","unstructured":"Smith M.B. Goradia V.K. Muzik A.C. Smith J.W. McCluggage S.G. Nichols R.L.:Increased intestinal antisepsis after addition of parenteral antibiotics to oral neomycin\u2010erythromycin. (unpublished data)."},{"key":"e_1_2_1_16_1","first-page":"298","article-title":"Antibiotics for colon surgery","volume":"35","author":"Cohn I.","year":"1958","journal-title":"Am. J. 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