{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:03:07Z","timestamp":1761487387364},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A prospective randomized study was carried out to evaluate the effectiveness of additional regional cytostatic perfusion of the extremities in patients with malignant melanoma. In a control group (n=54), the tumors were widely excised, and regional lymph nodes were dissected. The patients in the perfusion group (n=53) received additional hyperthermic (42\u00b0C) perfusion with Melphalan. The disease\u2010free survival time was chosen as the criterion for evaluation. An intermediate analysis revealed a highly significant difference between the 2\u00a0groups (21 recurrences in the control group and 4 recurrences in the perfusion group,<jats:italic>p&lt;<\/jats:italic> 0.001). Therefore, the study was discontinued prematurely.<\/jats:p><jats:p>In an analysis of the data performed after a median observation time of 5 years and 11\u00a0months, 26 recurrences were diagnosed in the control group, whereas 6 recurrences were noted in the perfusion group (<jats:italic>p<\/jats:italic>&lt; 0.001). The retrospective breakdown into different risk groups according to tumor thickness also demonstrates a significant difference. For patients with a primary tumor of 1.5\u20143.0\u2010mm in thickness, 2 of 25\u00a0in the perfusion group and 10 of 25\u00a0in the control group have relapsed. For those with a primary tumor of greater than 3.0\u2010mm in thickness, 4 of 28\u00a0in the perfusion group and 16 of 29\u00a0in the control group have relapsed. Eleven patients in the control group and 3 patients in the perfusion group have died due to metastatic spread of the melanoma (<jats:italic>p<\/jats:italic>&lt;0.01).<\/jats:p><jats:p>The results most clearly demonstrate the benefits of additional hyperthermic cytostatic perfusion.<\/jats:p>","DOI":"10.1007\/bf01658878","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T12:36:22Z","timestamp":1115555782000},"page":"598-602","source":"Crossref","is-referenced-by-count":46,"title":["Hyperthermic perfusion with chemotherapy for melanoma of the extremities"],"prefix":"10.1002","volume":"13","author":[{"given":"Farid","family":"Ghussen","sequence":"first","affiliation":[{"name":"Departments of Surgery and Dermatology University of Cologne Federal Republic of Germany"},{"name":"Department of Medical Oncology University of Wisconsin Madison Wisconsin USA"},{"name":"Von Hasewinkel Weg 73 5020 Frechen 4 Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Dermatology University of Cologne Federal Republic of Germany"},{"name":"Department of Medical Oncology University of Wisconsin Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard V.","family":"Smalley","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Dermatology University of Cologne Federal Republic of Germany"},{"name":"Department of Medical Oncology University of Wisconsin Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Groth","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Dermatology University of Cologne Federal Republic of Germany"},{"name":"Department of Medical Oncology University of Wisconsin Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197903)43:3<883::AID-CNCR2820430316>3.0.CO;2-V"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1979.tb03020.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Ariel I.M.:Malignant melanoma of the lower extremity. 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