{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:28:27Z","timestamp":1754486907325},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>A survey is given of colorectal polyps detected in a prospective randomized screening study with the fecal occult blood test. It is demonstrated that colonoscopy in persons with positive Hemoccult\u2010II tests results in detection of and removal of a higher number of adenomas than among controls. The strategy may, therefore, possibly be followed by a reduction of the incidence of colorectal cancer. Screen\u2010detected adenomas were most often in males and were larger than among controls; they were most often in the sigmoid colon, whereas the rectum was the most frequent location for adenomas in controls. Eight percent of persons with screen\u2010detected adenomas had some symptoms, which could be referred to adenomas, in contrast to 50% among controls<\/jats:bold>.<\/jats:p><jats:p><jats:bold>Hyperplastic polyps served as markers for adenomas in persons with positive Hemoccult\u2010II as well as in controls with adenomas detected by colonoscopy; however, most persons with adenomas had no hyperplastic polyps<\/jats:bold>.<\/jats:p><jats:p><jats:bold>Endoscopic polypectomy did not result in any severe complications, but surgical removal in 2 of 22 patients proved fatal<\/jats:bold>.<\/jats:p><jats:p><jats:bold>The results presented are compared with those of other prospective randomized trials. The optimistic view\u2014that the incidence of cancer may be reduced by polypectomy in persons with positive Hemoccult\u2010II tests\u2014stresses the importance of securing optimal colonoscopy service<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01658953","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T18:16:37Z","timestamp":1115576197000},"page":"7-13","source":"Crossref","is-referenced-by-count":19,"title":["Adenomas and hyperplastic polyps in screening studies"],"prefix":"10.1002","volume":"15","author":[{"given":"Karsten","family":"Bech","sequence":"first","affiliation":[{"name":"Departments of Surgical Gastroenterology and Pathology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Kronborg","sequence":"additional","affiliation":[{"name":"Departments of Surgical Gastroenterology and Pathology Odense University Hospital Odense Denmark"},{"name":"Department of Surgical Gastroenterology K Odense sygehus DK\u20105000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Fenger","sequence":"additional","affiliation":[{"name":"Departments of Surgical Gastroenterology and Pathology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197409)34:3 <936::AID-CNCR2820340722>3.0.CO;2-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709011142"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909093096"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528608996440"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.8.830"},{"key":"e_1_2_1_7_1","first-page":"2601","article-title":"Colorectal adenomas and cancer. Pathologic relationships","volume":"50","author":"Fenoglio C.M.","year":"1982","journal-title":"Cancer"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92750-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880801)62:3<645::AID-CNCR2820620333>3.0.CO;2-#"},{"key":"e_1_2_1_10_1","first-page":"35","volume-title":"Basic and Clinical Perspectives of Colorectal Polyps and Cancer","author":"Winawer S.J.","year":"1988"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.38.2.174"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.4.320"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509088874"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360944"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-11-880"},{"key":"e_1_2_1_16_1","first-page":"113","article-title":"Hyperplastic colonic polyps as a marker for adenomatous colonic polyps","volume":"84","author":"Ansher A.F.","year":"1989","journal-title":"Am. 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