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Graduated compression bandages exerting a mean ankle pressure of 42.1\u00b10.3\u00a0mmHg and a mean pressure of 17.3\u00b10.2\u00a0mmHg just below the knee healed 70% of ulcers within 12 weeks (n=44). Addition of the radical scavengers allopurinol (n=45) or dimethyl sulfoxide (n=44) to the compression bandages (daily application of the powder for 7\u00a0days, then once weekly applications to the end of the study at 3\u00a0months) significantly<\/jats:bold> (<jats:bold><jats:italic>p<\/jats:italic><\/jats:bold><jats:bold>&lt; 0.01) stimulated the healing of venous ulceration relative to controls when studied 4, 8, and 12 weeks after commencing treatment. After 3\u00a0months of treatment, allopurinol healed 93% and dimethyl sulfoxide healed 95% of the venous ulcers. The results suggest that oxygen\u2010derived free radicals are directly implicated in the mechanism of venous ulceration and are responsible for its persistence. Scavenging such radicals stimulates the healing of ulceration<\/jats:bold>.<\/jats:p>","DOI":"10.1007\/bf01659062","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T12:56:40Z","timestamp":1115557000000},"page":"264-269","source":"Crossref","is-referenced-by-count":51,"title":["The role of oxygen\u2010derived free radicals in the management of venous (varicose) ulceration: A new approach"],"prefix":"10.1002","volume":"15","author":[{"given":"Aws S.","family":"Salim","sequence":"first","affiliation":[{"name":"University Department of Surgery The Medical City Baghdad Iraq"},{"name":"Department of Surgery Ward 6 Stobhill General Hospital G21 3UW Glasgow Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"435","article-title":"Venous pressure in the saphenous system in normal, varicose and post\u2010phlebitic extremities","volume":"26","author":"Warren R.","year":"1949","journal-title":"Surgery"},{"key":"e_1_2_1_3_1","first-page":"92","article-title":"The post\u2010thrombotic syndrome","volume":"47","author":"Negus D.","year":"1970","journal-title":"Ann. 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