{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:34:13Z","timestamp":1779273253058,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ability of calcium to suppress the secretion of parathyroid hormone (PTH) is impaired in primary hyperparathyroidism (pHPT). Whether the nonadenomatous glands in pHPT also exhibit altered calcium\/PTH homeostasis is not known, but this may be the case since in the immediate postoperative period after surgery for pHPT, hypocalcemia often evolves in spite of a rapid normalization of serum levels of PTH. In this study, therefore, the suppression of serum levels of PTH by an oral calcium load was investigated pre\u2010 and postoperatively in 12 patients operated on for parathyroid adenoma. There was no difference in the calcemic response during the calcium load pre\u2010 and postoperatively. We found that the suppression of serum levels of PTH by calcium was increased already on the first postoperative day. However, postoperatively, the suppression of serum levels of PTH corrrelated positively to serum levels of ionized calcium and, furthermore, negatively to the weight of the excised parathyroid adenoma and the preoperative serum levels of ionized calcium. The results indicate that the function of the remaining parathyroid glands in patients with parathyroid adenoma could have been altered during the hyperparathyroid state and that postoperative hypocalcemia more readily evolves in patients with severe pHPT and impaired suppressibility of PTH (by calcium) in the remaining parathyroid glands.<\/jats:p>","DOI":"10.1007\/bf01659104","type":"journal-article","created":{"date-parts":[[2005,5,8]],"date-time":"2005-05-08T13:24:41Z","timestamp":1115558681000},"page":"806-810","source":"Crossref","is-referenced-by-count":6,"title":["Suppressibility of serum levels of PTH by calcium in the immediate postoperative period after surgery for primary hyperparathyroidism"],"prefix":"10.1002","volume":"17","author":[{"given":"Anders","family":"Bergenfelz","sequence":"first","affiliation":[{"name":"Department of Surgery Lund University S\u2010221 85 Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ahr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Surgery Lund University S\u2010221 85 Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-5-944"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-3-593"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-370"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1160457"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-56-3-572"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-46-2-267"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90446-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067339"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111696"},{"key":"e_1_2_1_11_1","first-page":"47","article-title":"Disturbance of basal and stimulated serum levels of intact parathyroid hormone in primary hyperparathyroidism","volume":"110","author":"Ljunghall S.","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_1_12_1","first-page":"668","article-title":"Measurement of intact parathyroid hormone in the diagnosis of hyperparathyroidism","volume":"125","author":"Bergenfelz A.","year":"1991","journal-title":"Acta Endocrinol. 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