{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:34:24Z","timestamp":1792020864897,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a randomized study subtotal parathyroidectomy (sPTX) was compared with total parathyroidectomy and autotransplantation of fresh tissue (PTX+AT) in 40 patients with severe secondary hyperparathyroidism (HPT). After surgery both groups were followed at 19\u00b16\u00a0months (PTX +AT) and 19\u00b17\u00a0months (sPTX) and at 43\u00b19\u00a0months (PTX+AT) and 40\u00b17\u00a0months (sPTX). There were 17 patients alive in each group at the time of the second follow\u2010up. After sPTX, 2 patients required re\u2010operation because of recurrent disease originating from the remaining parathyroid gland in the neck and another 2 patients were hypercalcemic at follow\u2010up. After PTX + AT both serum calcium and alkaline phosphatase normalized significantly more often (<jats:bold><jats:italic>p<\/jats:italic><\/jats:bold> &lt;<jats:bold>0.03)<\/jats:bold> than after sPTX. Re\u2010operations were not required in this group. Radiological signs also improved significantly more after PTX+AT, as did clinical signs like pruritus (<jats:bold><jats:italic>p<\/jats:italic><\/jats:bold><jats:bold>&lt; 0.005)<\/jats:bold> and muscle weakness (<jats:bold><jats:italic>p<\/jats:italic><\/jats:bold><jats:bold>&lt;0.04)<\/jats:bold>. These results and the fact that in recurrent disease a re\u2010operation at the autograft in the forearm is simpler than a re\u2010operation in the neck, lead to the recommendation that PTX+ AT should be considered as the method of choice in the surgical treatment of secondary HPT.<\/jats:p>","DOI":"10.1007\/bf01665309","type":"journal-article","created":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T05:56:58Z","timestamp":1115618218000},"page":"745-750","source":"Crossref","is-referenced-by-count":171,"title":["Subtotal parathyroidectomy versus total parathyroidectomy and autotransplantation in secondary hyperparathyroidism: A randomized trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Matthias","family":"Rothmund","sequence":"first","affiliation":[{"name":"Department of Surgery Philipps University Marburg Federal Republic of Germany"},{"name":"Klinik f\u00fcr Allgemeinchirurgie Klinikum Lahnberge Baidingerstra\u00dfe 3550 Marburg Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Surgery Philipps University Marburg Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Schark","sequence":"additional","affiliation":[{"name":"Department of Surgery Philipps University Marburg Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1991,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198301001-00002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)90678-4"},{"key":"e_1_2_1_4_1","first-page":"1","article-title":"Parathyroid glands in thyroid surgery","volume":"389","author":"Alveryd A.","year":"1968","journal-title":"Acta Chir. 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Wschr."},{"key":"e_1_2_1_18_1","first-page":"384","article-title":"Results with parathyroidectomy and autotransplantation in patients with secondary HPT","volume":"115","author":"Thompson B.W.","year":"1980","journal-title":"Arch. Surg."},{"key":"e_1_2_1_19_1","first-page":"276","article-title":"Total parathyroidectomy and autotransplantation","volume":"16","author":"Diaz\u2010Buxo J.A.","year":"1981","journal-title":"Clin. Nephrol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198106000-00014"},{"key":"e_1_2_1_21_1","first-page":"177","article-title":"Total parathyroidectomy and parathyroid autotransplantation in patients with chronic renal failure","volume":"153","author":"Max M.H.","year":"1981","journal-title":"Surg. Gynecol. 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