{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:14:13Z","timestamp":1789748053240,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[1992,6]]},"DOI":"10.1007\/bf01694366","type":"journal-article","created":{"date-parts":[[2005,5,15]],"date-time":"2005-05-15T07:08:33Z","timestamp":1116140913000},"page":"364-367","source":"Crossref","is-referenced-by-count":16,"title":["Effects of aprotinin on hemorrhagic complications in ARDS patients during prolonged extracorporeal CO2 removal"],"prefix":"10.1007","volume":"18","author":[{"given":"F.","family":"Brunet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Mira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Belghith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Lanore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schlumberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Toulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Dhainaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01694366_CR1","first-page":"359","volume":"28","author":"L Uziel","year":"1982","unstructured":"Uziel L, Agostini A, Pirovano E (1982) Haematologic survey during low frequency positive pressure ventilation with extracorporeal CO2 removal. Trans Am Soc Artif Intern Organs 28:359\u2013364","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"BF01694366_CR2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1537-2995.1990.30490273436.x","volume":"30","author":"D McCoy-Pardington","year":"1990","unstructured":"McCoy-Pardington D, Judd WJ, Knafl P, Abruzzo LV, Coombes KR, Butch SH, Oberman HA (1990) Blood use during extracorporeal membrane oxygenation. Transfusion 30:307\u2013309","journal-title":"Transfusion"},{"key":"BF01694366_CR3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/00003246-199005000-00006","volume":"18","author":"TP Green","year":"1990","unstructured":"Green TP, Ischam-Schopf B, Steinhorn RH, Smith C, Irmiter RJ (1990) Whole blood activating clotting time in infants during extracorporeal membrane oxygenation. Crit Care Med 18:494\u2013498","journal-title":"Crit Care Med"},{"key":"BF01694366_CR4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2165\/00003495-198529030-00003","volume":"29","author":"M Verstraete","year":"1985","unstructured":"Verstraete M (1985) Clinical application of inhibitors of fibrinolysis. Drugs 29:236\u2013261","journal-title":"Drugs"},{"key":"BF01694366_CR5","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0003-4975(10)62153-4","volume":"44","author":"W Oeveren Van","year":"1987","unstructured":"Van Oeveren W, Jansen NJG, Bidstrup BP, Royston D, Westaby S, Neuhof H, Wildevuur CRH (1987) Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 44:640\u2013645","journal-title":"Ann Thorac Surg"},{"key":"BF01694366_CR6","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0140-6736(87)91190-1","volume":"II","author":"D Royston","year":"1987","unstructured":"Royston D, Taylor KM, Bidstrup BP, Sapsford RN (1987) Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet II:1289\u20131291","journal-title":"Lancet"},{"key":"BF01694366_CR7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1055\/s-2007-1013915","volume":"37","author":"W Dietrich","year":"1989","unstructured":"Dietrich W, Barankay A, Dilthey G, Henze R, Niekau E, Sebening F, Richter JA (1989) Reduction of homologous blood requirement in cardiac surgery by intraoperative aprotinin application. Clinical experience in 152 cardiac surgical patients. Thorac Cardiovasc Surg 37:92\u201398","journal-title":"Thorac Cardiovasc Surg"},{"key":"BF01694366_CR8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-2007-1013914","volume":"37","author":"G Fraedrich","year":"1989","unstructured":"Fraedrich G, Weber C, Bernard C, hettwer A, Schlosser V (1989) Reduction of blood transfusion requirement in open heart surgery by administration of high doses of aprotinin. Preliminary results. Thorac Cardiovasc Surg 37:89\u201391","journal-title":"Thorac Cardiovasc Surg"},{"key":"BF01694366_CR9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/jama.1986.03380070087025","volume":"256","author":"L Cattinoni","year":"1986","unstructured":"Cattinoni L, Pesenti A, Mascheroni D et al. (1986) Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure. JAMA 256:881\u2013886","journal-title":"JAMA"},{"key":"BF01694366_CR10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-0038-1647683","volume":"32","author":"M Moriau","year":"1974","unstructured":"Moriau M, Rodhain J, Noel H, De Beys-Col C, Masure R (1974) Comparative effects of proteinase inhibitors plasminogen antiactivators, heparin and acetylsalicylic acid on the experimental DIC induced by thrombin. Thromb Haemostat 32:171\u2013188","journal-title":"Thromb Haemostat"},{"key":"BF01694366_CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1476-5381.1985.tb08909.x","volume":"86","author":"B Hugues","year":"1985","unstructured":"Hugues B, Parratt JR (1985) The effects of the protease inhibitor, aprotinin, on the course of shock induced by endotoxin in cats. Br J Pharmacol 86:399\u2013403","journal-title":"Br J Pharmacol"},{"key":"BF01694366_CR12","first-page":"318","volume":"11","author":"G Vandeplassche","year":"1983","unstructured":"Vandeplassche G, Schrauwen E, Houvenaghel (1983) Effects of the protease inhibitor aprotinin in endotoxin-shocked piglets. IRCS Med Sci 11:318\u2013319","journal-title":"IRCS Med Sci"},{"key":"BF01694366_CR13","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/0022-4804(86)90087-9","volume":"41","author":"R Winn","year":"1986","unstructured":"Winn R, Gleisner J, Maunder R, Harlan J, Hildebrant J (1986) Lung permeability and hemodynamics during endotoxemia: effect of aprotinin. J Surg Res 41:620\u2013626","journal-title":"J Surg Res"},{"key":"BF01694366_CR14","first-page":"19","volume":"9","author":"A Etienne","year":"1987","unstructured":"Etienne A, Hecquet F, Guilmard C, Soulard C, Braquet P (1987) Inhibition of rat endotoxin-induced lethality by BN 52021 and BN 52063, compounds with PAF-acether antagonistic effect and protease-inhibitory activity. Int J Tissue Reac 9:19\u201326","journal-title":"Int J Tissue Reac"},{"key":"BF01694366_CR15","first-page":"372","volume":"62","author":"Y Katsuura","year":"1989","unstructured":"Katsuura Y, Kimura Y, Ohno N, Naito T, Okamoto S, Wanaka K (1989) DIC with and without MOF like syndrome: effect of selective synthetic-inhibitor (abstract). Thromb Haemostat 62:372","journal-title":"Thromb Haemostat"},{"key":"BF01694366_CR16","first-page":"7","volume":"155","author":"E Svartholm","year":"1989","unstructured":"Svartholm E, Haglund U, Ljungberg J, Hedner U (1989) Influence of aprotinin, a protease inhibitor, on porcineE. coli shock. Acta Chir Scand 155:7\u201313","journal-title":"Acta Chir Scand"},{"key":"BF01694366_CR17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0002-9610(85)90434-9","volume":"150","author":"GE Chalkladakis","year":"1985","unstructured":"Chalkladakis GE, Kostakis A, Karydakis P et al. (1985) Effect of aprotinin on fibrinopurulent peritonitis in rats. Am J Surg 150:550\u2013553","journal-title":"Am J Surg"},{"key":"BF01694366_CR18","first-page":"2760","volume":"38","author":"G Haberland","year":"1979","unstructured":"Haberland G, McConn R (1979) A rationale for the therapeutic action of aprotinin. Fed Proc 38:2760\u20132767","journal-title":"Fed Proc"},{"key":"BF01694366_CR19","first-page":"367","volume":"155","author":"C Putterman","year":"1989","unstructured":"Putterman C (1989) Aprotinin therapy in septic shock (letter). Acta Chir Scand 155:367","journal-title":"Acta Chir Scand"},{"key":"BF01694366_CR20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1055\/s-0038-1645960","volume":"58","author":"F Martinez-Brotons","year":"1987","unstructured":"Martinez-Brotons F, Oncins JR, Mestres J, Amargos V, Reynaldo C (1987) Plasma kallicrein-kinin system in uncomplicated sepsis and septic shock-comparison with cardiogenic shock. Thromb Haemostat 58:709\u2013713","journal-title":"Thromb Haemostat"},{"key":"BF01694366_CR21","first-page":"824","volume":"56","author":"LA Harker","year":"1980","unstructured":"Harker LA, Malpass TW, Branson HE, Hessel EA II, Slichter SJ (1980) Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release. Blood 56:824\u2013834","journal-title":"Blood"},{"key":"BF01694366_CR22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-0038-1646770","volume":"59","author":"DS Holloway","year":"1988","unstructured":"Holloway DS, Summaria L, Sandesara J, Vagher JP, Alewander JC, Caprini JA (1988) Decreased platelet number and function and increased fibrinolysis contribute to post operative bleeding in cardiopulmonary bypass patients. Thromb Haemostat 59:62\u201367","journal-title":"Thromb Haemostat"},{"key":"BF01694366_CR23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0888-6296(89)92642-2","volume":"3","author":"K Tanaka","year":"1989","unstructured":"Tanaka K, Takao M, Yada I, Yuasa H, Kusagawa M, Degushi K (1989) Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery. J Cardiothorac Anesth 3:181\u2013188","journal-title":"J Cardiothorac Anesth"},{"key":"BF01694366_CR24","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0003-4975(10)62153-4","volume":"44","author":"W Oeveren Van","year":"1987","unstructured":"Van Oeveren W, Jansen NJG, Bidstrup BP, Royston D, Westaby S, Neuhof H, Wildevuur CRH (1987) Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 44:640\u2013645","journal-title":"Ann Thorac Surg"},{"key":"BF01694366_CR25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-5223(19)36893-X","volume":"99","author":"W Oeveren Van","year":"1990","unstructured":"Van Oeveren W, Harder MP, Roozendaal KJ, Eijsman L, Wildevuur CRH (1990) Aprotinin protects platelets against the initial effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 99:788\u2013797","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01694366_CR26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/00000542-199012000-00009","volume":"73","author":"W Dietrich","year":"1990","unstructured":"Dietrich W, Spannagl M, Jochum M et al. (1990) Influence of highdose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization. Anesthesiology 73:1119\u20131126","journal-title":"Anesthesiology"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01694366.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01694366\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01694366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T10:17:27Z","timestamp":1586254647000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01694366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["BF01694366"],"URL":"https:\/\/doi.org\/10.1007\/bf01694366","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}