{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T17:31:15Z","timestamp":1698514275175},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[1995,6]]},"DOI":"10.1007\/bf01705534","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:27:46Z","timestamp":1118543266000},"page":"669-674","source":"Crossref","is-referenced-by-count":13,"title":["Affinities of muscarinic drugs for [3H]N-methylscopolamine (NMS) and [3H]oxotremorine (OXO) binding to a mixture of M1\u2212M4 muscarinic receptors: Use of NMS\/OXO-M ratios to group compounds into potential agonist, partial agonist, and antagonist classes"],"prefix":"10.1007","volume":"20","author":[{"given":"N. A.","family":"Sharif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. W.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"DeSantis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01705534_CR1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0163-7258(93)90027-B","volume":"58","author":"M. P. Caulfield","year":"1993","unstructured":"Caulfield, M. P. 1993. Muscarinic receptors: characterization, coupling and function. Pharmacol. Ther. 58:319\u2013379.","journal-title":"Pharmacol. Ther."},{"key":"BF01705534_CR2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1146\/annurev.pa.30.040190.003221","volume":"30","author":"E. C. Hulme","year":"1990","unstructured":"Hulme, E. C., Birdsall, N. J. M., and Buckley, N. J. 1990. Muscarinic receptor subtypes. Annu. Rev. Pharmacol. Toxicol. 30: 633\u2013673.","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"BF01705534_CR3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0165-6147(93)90049-P","volume":"14","author":"J. Wess","year":"1993","unstructured":"Wess, J. 1993. Molecular basis of muscarinic acetylcholine receptor function. Trends Pharmacol. Sci. 14:308\u2013313.","journal-title":"Trends Pharmacol. Sci."},{"key":"BF01705534_CR4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1476-5381.1988.tb11451.x","volume":"93","author":"S. B. Freedman","year":"1988","unstructured":"Freedman, S. B., Harley, E. A., and Iversen, L. L. 1988. Relative affinities of drugs acting at cholinoceptors in displacing agonist and antagonist radioligands: the NMS\/OXO-M ratio as an index of efficacy at cortical muscarinic receptors. Br. J. Pharmacol. 93: 437\u2013445.","journal-title":"Br. J. Pharmacol."},{"key":"BF01705534_CR5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1476-5381.1989.tb11838.x","volume":"96","author":"R. E. Delmendo","year":"1989","unstructured":"Delmendo, R. E., Michel, A. D., and Whiting, R. L. 1989. Affinity of muscarinic receptor antagonists for three putative muscarinic receptor binding sites. Br. J. Pharmacol. 96:457\u2013464.","journal-title":"Br. J. Pharmacol."},{"key":"BF01705534_CR6","first-page":"805","volume":"38","author":"S. Lazareno","year":"1990","unstructured":"Lazareno, S., Buckley, N. J., and Roberts, F. F. 1990. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart and NG108-15 cells. Mol. Pharmacol. 38:805\u2013815.","journal-title":"Mol. Pharmacol."},{"key":"BF01705534_CR7","doi-asserted-by":"crossref","first-page":"11738","DOI":"10.1016\/S0021-9258(18)99019-8","volume":"266","author":"J. T. Ransom","year":"1991","unstructured":"Ransom, J. T., Cherwinski, H. M., Delmendo, R., Sharif, A., and Eglen, R. M. 1991. Characterization of the M4 muscarinic receptor Ca2+ response in a subclone of PC-12 cells by single cell flow cytometry. Inhibition of the response by bradykinin. J. Biol. Chem. 266:11738\u201311745.","journal-title":"J. Biol. Chem."},{"key":"BF01705534_CR8","unstructured":"Michel, A. D., and Whiting, R. L. 1984. Analysis of ligand binding data using a microcomputer. Br. J. Pharmacol. 83:460p."},{"key":"BF01705534_CR9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1476-5381.1991.tb12277.x","volume":"102","author":"N. A. Sharif","year":"1991","unstructured":"Sharif, N. A., Wong, E. H. F., Loury, D., Stefanich, E., Eglen, R. M., Michel, A. D., and Whiting, R. L. 1991. Characteristics of 5HT3 binding sites in rat cerebral cortex, NG108-15 and NCB-20 neuroblastoma cells using [3H]quipazine and [3H]GR65630 binding. Br. J. Pharmacol. 102:919\u2013925.","journal-title":"Br. J. Pharmacol."},{"key":"BF01705534_CR10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ddr.430330408","volume":"33","author":"N. A. Sharif","year":"1994","unstructured":"Sharif, N. A., Xu, S., and Yanni, J. M. 1994. Histamine receptor-subtype affinities, selectivities and potencies of emedastine, a novel H1-selective antagonist, and other ocularly employed antihistamines. Drug Develop. Res. 33:448\u2013453.","journal-title":"Drug Develop. Res."},{"key":"BF01705534_CR11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0160-5402(85)90034-8","volume":"14","author":"G. A. McPherson","year":"1985","unstructured":"McPherson, G. A. 1985. Analysis of radioligand binding experiments. A collection of computer programs for the IBM.PC. J. Pharmacol. Methods 14:213\u2013228.","journal-title":"J. Pharmacol. Methods"},{"key":"BF01705534_CR12","first-page":"237","volume":"266","author":"S. Z. Wang","year":"1993","unstructured":"Wang, S. Z. and El-Fakahany, E. E. 1993. Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists. J. Pharmacol. Expt. Ther. 266:237\u2013243.","journal-title":"J. Pharmacol. Expt. Ther."},{"key":"BF01705534_CR13","first-page":"895","volume":"38","author":"J. Hu","year":"1990","unstructured":"Hu, J., and El-Fakahany, E. E. 1990. Selectivity of McN-A-343 in stimulating phosphoinositide hydrolysis by M1 muscarinic receptors. Mol. Pharmacol. 38:895\u2013903.","journal-title":"Mol. Pharmacol."},{"key":"BF01705534_CR14","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1476-5381.1995.tb13339.x","volume":"114","author":"M. H. Richards","year":"1995","unstructured":"Richards, M. H., and Van Giersbergen, P. L. M. 1995. Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists. Br. J. Pharmacol. 114:1241\u20131249.","journal-title":"Br. J. Pharmacol."},{"key":"BF01705534_CR15","first-page":"410","volume":"28","author":"F. J. Ehlert","year":"1985","unstructured":"Ehlert, F. J. 1985. The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium. Mol. Pharmacol. 28:410\u2013421.","journal-title":"Mol. Pharmacol."},{"key":"BF01705534_CR16","first-page":"393","volume":"23","author":"M. C. Olianas","year":"1982","unstructured":"Olianas, M. C., Onali, P., Neff, N. H., and Costa, E. 1982. Adenylate cyclase activity of synaptic membranes from rat striatum. Inhibition by muscarinic receptor agonists. Mol. Pharmacol. 23: 393\u2013398.","journal-title":"Mol. Pharmacol."},{"key":"BF01705534_CR17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0922-4106(93)90058-H","volume":"244","author":"R. M. Eglen","year":"1993","unstructured":"Eglen, R. M., Sharif, N. A., and To, Z. P. 1993. Muscarinic M3 receptors mediate total inositol phosphates accumulation in murine HSDM1C1 fibrosarcoma cells. Eur. J. Pharmacol. (Mol. Pharmacol. section) 244:49\u201355.","journal-title":"Eur. J. Pharmacol. (Mol. Pharmacol. section)"},{"key":"BF01705534_CR18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00995154","volume":"20","author":"N. A. Sharif","year":"1995","unstructured":"Sharif, N. A., To, Z. P., Wong, K. H., Delmendo, R. E., Whiting, R. L., and Eglen, R. M. 1995. M3 muscarinic receptors on murine HSDM1C1 cell: further functional, regulatory and receptor binding studies. Neurochem. Res. 20:61\u201368.","journal-title":"Neurochem. Res."}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01705534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01705534\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01705534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T18:16:29Z","timestamp":1626027389000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01705534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["BF01705534"],"URL":"https:\/\/doi.org\/10.1007\/bf01705534","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}