{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:52:53Z","timestamp":1783947173365,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[1996,5]]},"DOI":"10.1007\/bf01712176","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:34:33Z","timestamp":1118496873000},"page":"500-506","source":"Crossref","is-referenced-by-count":13,"title":["Prolonged gramulocyte activation, as well as hypoxanthine and free radical production after open heart surgery in children"],"prefix":"10.1007","volume":"22","author":[{"given":"E. J.","family":"Pesonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Korpela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leijala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sairanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. M.","family":"Pitk\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. O.","family":"Ravio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Venge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01712176_CR1","first-page":"416","volume-title":"Free radicals in biology and medicine","year":"1989","unstructured":"Halliwell B, Gutteridge JMC (eds) (1989) Free radicals in biology and medicine. Oxford University Press, New York, pp 416\u2013508"},{"key":"BF01712176_CR2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.7326\/0003-4819-107-4-526","volume":"107","author":"CE Cross","year":"1987","unstructured":"Cross CE, Halliwell B, Borish ET (1987) Oxygen radicals and human disease. Ann Intern Med 107: 526\u2013545","journal-title":"Ann Intern Med"},{"key":"BF01712176_CR3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0003-4975(89)90047-7","volume":"47","author":"P Menasch\u00e9","year":"1989","unstructured":"Menasch\u00e9 P, Piwnica A (1989) Free radicals and myocardial protection: a surgical viewpoint. Ann Thorac Surg 47: 939\u2013945","journal-title":"Ann Thorac Surg"},{"key":"BF01712176_CR4","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0022-5223(19)35998-7","volume":"91","author":"D Royston","year":"1986","unstructured":"Royston D, Fleming JS, Desai JB, Westaby S, Taylor KM (1986) Increased production of peroxidation products associated with cardiac operations. J Thorac Cardiovasc Surg 91: 759\u2013766","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1055\/s-2007-1023335","volume":"32","author":"V Alex-Meskhishvili","year":"1984","unstructured":"Alex-Meskhishvili V, Popov SA, Nikoljuk AP (1984) Evaluation of hemodynamics in infants and small babies after open heart surgery. Thorac Cardiovasc Surg 32: 4\u20139","journal-title":"Thorac Cardiovasc Surg"},{"key":"BF01712176_CR6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","volume":"312","author":"JM McCord","year":"1985","unstructured":"McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312: 159\u2013163","journal-title":"N Engl J Med"},{"key":"BF01712176_CR7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/1010-7940(90)90143-N","volume":"4","author":"AG Semb","year":"1990","unstructured":"Semb AG, Forsdahl K, Vaage J (1990) Granulocyte and eicosanoid gradients across the coronary circulation during myocardial reperfusion in cardiac surgery Eur J Cardiothorac Surg 4: 543\u2013548","journal-title":"Eur J Cardiothorac Surg"},{"key":"BF01712176_CR8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0003-2697(87)90150-3","volume":"167","author":"V Stocchi","year":"1987","unstructured":"Stocchi V, Cucchiarini L, Canestrari F, Piacentini MP, Fornaini G (1987) A very fast ion-pair reversed-phase HPLC method for the separation of the most significant nucleotides and their degradation products in human red blood cells. Anal Bioichem 167: 181\u2013190","journal-title":"Anal Bioichem"},{"key":"BF01712176_CR9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0609.1977.tb02080.x","volume":"18","author":"T Olofsson","year":"1977","unstructured":"Olofsson T, Olsson I, Venge P (1977) Myeloperoxidase and lactoferrin of blood neutrophils and plamsa in chronic granulocytic leukaemia. Scand J Haematol 18: 113\u2013120","journal-title":"Scand J Haematol"},{"key":"BF01712176_CR10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF02535255","volume":"24","author":"OM Pit\u00e4nen","year":"1989","unstructured":"Pit\u00e4nen OM, Hallman M, Andersson SM (1989) Determination of ethane and pentane in free oxygen radical-induced lipid peroxidation. Lipids 24: 157\u2013159","journal-title":"Lipids"},{"key":"BF01712176_CR11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0022-3476(05)82668-X","volume":"116","author":"OM Pitk\u00e4nen","year":"1990","unstructured":"Pitk\u00e4nen OM, Hallman M, Andersson SM (1990) Correlation of free oxygen radical-induced lipied peroxiation with outcome in very low weight infants. J Pediatr 116: 760\u2013764","journal-title":"J Pediatr"},{"key":"BF01712176_CR12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0609.1987.tb00779.x","volume":"39","author":"P Venge","year":"1987","unstructured":"Venge P, Nilsson L, Nystr\u00f6m S-O, \u00c5berg T (1987) Serum and plasma measurements of neutrophil granule proteins during cardiopulmonary bypass: a model to estimate human turnover of lactoferrin and myeloperoxidase. Eur J Haematol 39: 339\u2013345","journal-title":"Eur J Haematol"},{"key":"BF01712176_CR13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJM198102263040901","volume":"304","author":"DE Chenoweth","year":"1981","unstructured":"Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Blackstone EH, Kirklin JW (1981) Complement activation during cardiopulmonary bypass. N Engl J Med 304: 497\u2013503","journal-title":"N Engl J Med"},{"key":"BF01712176_CR14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9149(91)90821-2","volume":"68","author":"A Thomassen","year":"1991","unstructured":"Thomassen A, Nielsen TT, Bagger JP, Pedersen AK, Henningsen P (1991) Antiischemic and metabolic effects of glutamate during pacing in patients with stable angina pectoris secondary to either coronary artery disease or syndrome X. Am J Cardiol 68: 291\u2013295","journal-title":"Am J Cardiol"},{"key":"BF01712176_CR15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/clinchem\/35.5.898","volume":"35","author":"J Robbrecht","year":"1989","unstructured":"Robbrecht J, De Buyzere M, Delanghe J, De Scheerder I, Mortier E, Vanderschueren S (1989) Increase of hypoxanthine during cardiac surgery, as measured by an indirect automated enzymatic assay. Clin Chem 35: 898\u2013899","journal-title":"Clin Chem"},{"key":"BF01712176_CR16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/1010-7940(92)90094-E","volume":"6","author":"RT Smolenski","year":"1992","unstructured":"Smolenski RT, Lachno DR, Yacoub MH (1992) Adenine nucleotide catabolism in human myocardium during heart and hear-lung transplantation. Eur J Cardiothorac Surg 6: 25\u201330","journal-title":"Eur J Cardiothorac Surg"},{"key":"BF01712176_CR17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/0140-6736(93)91074-V","volume":"341","author":"ED Grech","year":"1993","unstructured":"Grech ED, Dodd NJF, Bellamy CM, Perry RA, Morrison WL, Ramsdale DR (1993) Free-radical generation during angioplasty reperfusion for acute myocardial infarctiion. Lancet 341: 990\u2013991","journal-title":"Lancet"},{"key":"BF01712176_CR18","first-page":"61","volume":"342","author":"KI Breizi","year":"1993","unstructured":"Breizi KI, Soutar A, Hayes PC (1993) Free radial production followin vascular reperfusion. Lancet 342: 61\u201362","journal-title":"Lancet"},{"key":"BF01712176_CR19","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1152\/jappl.1989.66.3.1268","volume":"66","author":"MP Habib","year":"1989","unstructured":"Habib MP, Katz MA (1989) Soiurce of ethane in expirate of rats ventilated with 100% oxygen. J Appl Physiol 66: 1268\u20131272","journal-title":"J Appl Physiol"},{"key":"BF01712176_CR20","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/BF02533308","volume":"12","author":"EE Dumelin","year":"1977","unstructured":"Dumelin EE, Tappel AL (1977) Hydrocarbon gases produced during in vitro peroxidation of polynsaturated fatty acids and decomposition of preformed hydroperoxides. Lipids 12: 894\u2013900","journal-title":"Lipids"},{"key":"BF01712176_CR21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/00365519209088373","volume":"52","author":"OM Pitk\u00e4nen","year":"1992","unstructured":"Pitk\u00e4nen OM (1992) Are ethane and pentane evolution and thiobarbituric acid reactivity specific for lipid peroxidation in erythrocyte membrane? Scand J Clin Lab Invest 52: 379\u2013385","journal-title":"Scand J Clin Lab Invest"},{"key":"BF01712176_CR22","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/0006-2952(90)90011-9","volume":"39","author":"W Kessler","year":"1990","unstructured":"Kessler W, Remmer H (1990) Generation of volatile hydrocarbons from amino acids and proteins by an iron\/asciorbate\/GSH system. Biochem Pharmacol 39: 1347\u20131351","journal-title":"Biochem Pharmacol"},{"key":"BF01712176_CR23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0003-4975(10)61060-0","volume":"32","author":"JK Kirklin","year":"1981","unstructured":"Kirklin JK, Kirklin JW (1981) Management of the cardiovascular subsystem after cardiac surgery. Ann Thorac Surg 32: 311\u2013319","journal-title":"Ann Thorac Surg"},{"key":"BF01712176_CR24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0022-5223(19)35207-9","volume":"96","author":"FA Borros","year":"1988","unstructured":"Borros FA, Williams WG, Teoh KH (1988) Mycoardial performance after repair of congenital cardiac defects in infants and children. J Thorac Cardiovasc Surg 96: 548\u2013556","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1378\/chest.88.5.763","volume":"88","author":"CM Grum","year":"1985","unstructured":"Grum CM, Simon RH, Dantzker DR, Fox IH (1985) Evidence for adenosine triphosphate degradation in critically ill patients. Chest 88: 763\u2013767","journal-title":"Chest"},{"key":"BF01712176_CR26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0022-5223(20)31421-5","volume":"102","author":"NJG Jansen","year":"1991","unstructured":"Jansen NJG, van Oeveren W, v d Broek L, Oudemans-van Straaten HM, Stoutenbeek CP, Chang Njoek Joen M, Roozendaal KJ, Eysman L, Wildevuur CRH (1991) Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass. J Thorac Cardiovasc Surg 102: 515\u2013525","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0002-8703(91)90950-M","volume":"121","author":"WD Johnson","year":"1991","unstructured":"Johnson WD, Kayser KL, Brenowitz JB, Saedi SF (1991) A randomized controlled trial of allpurinol in coronary bypass surgery. Am Heart J 121: 20\u201324","journal-title":"Am Heart J"},{"key":"BF01712176_CR28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0022-5223(19)34730-0","volume":"104","author":"J Borowiec","year":"1992","unstructured":"Borowiec J, Thelin S, Bagge L, Nilsson L, Venge P, Hansson HE (1992) Heparin-coated circuits reduce activation of granulocytes during cardiopulmonary bypass. A clinical study. J Thorac Cardiovasc Surg 104: 642\u2013647","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR29","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0003-4975(93)90117-Z","volume":"55","author":"YJ Gu","year":"1993","unstructured":"Gu YJ, Oeveren W van, Akkerman C, Boonstra PW, Huyzen RJ, Wildevuur CRH (1993) Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 55: 917\u2013922","journal-title":"Ann Thorac Surg"},{"key":"BF01712176_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5223(19)33735-3","volume":"106","author":"YA Wachtfogel","year":"1993","unstructured":"Wachtfogel YA, Kucich U, Hack CE, Gluszko P, Niewiarowski S, Colman RW, Edmunds LH (1993) Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion. J Thorac Cardiovasc Surg 106: 1\u201310","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR31","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0022-5223(94)70037-0","volume":"107","author":"D Johnson","year":"1994","unstructured":"Johnson D, Thomson D, Hurst T, Prasad K, Wilson T, Murphy F, Saxena A, Mayers I (1994) Neutrophilmediated acute lung injury after extracorporeal perfusion. J Thorac Cardiovasc Surg 107: 1193\u20131202","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0022-5223(19)36903-X","volume":"99","author":"K Bando","year":"1990","unstructured":"Bando K, Pillai R, Cameron DE, Brawn JD, Winkelstein JA, Hutchins GM, Reitz BA, Baumagartner WA (1990) Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass. J Thorac Cardiovasc Surg 99: 873\u2013877","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR33","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1525-1594.1993.tb00611.x","volume":"17","author":"YJ Gu","year":"1993","unstructured":"Gu YJ, Obster R, Hann J, Gallandat-Huet RC, Eijgelaar A, Oeveren W van (1993) Biocompatibility of leukocyte removal filters during leukocyte filtration of cardiopulmonary bypass perfusate. Artif Organs 17: 660\u2013665","journal-title":"Artif Organs"},{"key":"BF01712176_CR34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0022-5223(19)35212-2","volume":"96","author":"P Menasch\u00e9","year":"1988","unstructured":"Menasch\u00e9 P, Pasquier C, Bellucci S, Lorente P, Jaillon P, Piwnica A (1988) Deferoxamine reduces neutrophilmediated free radical production during cardiopulmonary bypass in man. J Thorac Cardiovasc Surg 96: 582\u2013589","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01712176_CR35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0022-4804(86)90093-4","volume":"40","author":"NC Cavarocchi","year":"1986","unstructured":"Cavarocchi NC, England MD, O'Brien JF, Solis E, Russo P, Schaff HV, Orszulak TA, Pluth JR, Kaye MP (1986) Superoxide generatin during cardiopulmonary bypass: is there a role for vitamin E? J Surg Res 40: 519\u2013527","journal-title":"J Surg Res"},{"issue":"Suppl III","key":"BF01712176_CR36","first-page":"134","volume":"74","author":"MD England","year":"1986","unstructured":"England MD, Cavarocchi NC, O'Brien J, Solis E, Pluth JR, Orszulak TA, Kaye MP, Schaff HV (1986) Ihfluence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass. Circulation 74 [Suppl III]: 134\u2013137","journal-title":"Circulation"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01712176.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01712176\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01712176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T14:59:48Z","timestamp":1706281188000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01712176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["BF01712176"],"URL":"https:\/\/doi.org\/10.1007\/bf01712176","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}