{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:23:19Z","timestamp":1780608199849,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[1995,11]]},"DOI":"10.1007\/bf01713564","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:21:41Z","timestamp":1118503301000},"page":"349-355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A randomized study of imipenem compared to cefotaxime plus piperacillin as initial therapy of infections in granulocytopenic patients","Randomisierte Studie mit Imipenem versus Cefotaxim\/Piperacillin in der Initialtherapie von Infektionen granulozytopenischer Patienten"],"prefix":"10.1007","volume":"23","author":[{"given":"Angelika","family":"B\u00f6hme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hoelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Just-N\u00fcbling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Stille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"Suppl. 1A","key":"BF01713564_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0002-9343(86)90510-3","volume":"81","author":"G. P. Bodey","year":"1986","unstructured":"Bodey, G. P. Infection in cancer patients. Am. J. Med. 81 (Suppl. 1A) (1986) 11\u201326.","journal-title":"Am. J. Med."},{"key":"BF01713564_CR2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0002-9343(84)90663-6","volume":"76","author":"P. A. Pizzo","year":"1984","unstructured":"Pizzo, P. A., Commers, J., Cotton, D., Gress, J., Hathorn, J., Hiemenz, J., Longo, D., Marshall, D., Robichaud, K. J. Approaching the controversies in antibacterial management of cancer patients. Am. J. Med. 76 (1984) 436\u2013449.","journal-title":"Am. J. Med."},{"key":"BF01713564_CR3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0002-9343(88)90140-4","volume":"84","author":"E. J. Anaissie","year":"1988","unstructured":"Anaissie, E. J., Fainstein, V., Bodey, G. P., Rolston, K., Elting, L., Kantarjian, H., Cabanillas, F., Mc Credie, K. B. Randomized trial of beta-lactam regimens in febrile neutropenic cancer patients. Am. J. Med. 84 (1988) 581\u2013589.","journal-title":"Am. J. Med."},{"key":"BF01713564_CR4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/infdis\/161.3.381","volume":"161","author":"W. T. Hughes","year":"1990","unstructured":"Hughes, W. T., Armstrong, D., Bodey, G. P., Feld, R., Mandell, G. L., Meyers, J. D., Pizzo, P. A., Schimpff, S. C., Shenep, J. L., Wade, J. C., Young, L. S., Yow, M. D. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J. Infect. Dis. 161 (1990) 381\u2013396.","journal-title":"J. Infect. Dis."},{"issue":"Suppl. 1","key":"BF01713564_CR5","first-page":"35","volume":"24","author":"J. Klastersky","year":"1988","unstructured":"Klastersky, J., Zinner, S. H., Calandra, T., Gaya, H., Glauser, M. P., Meunier, F., Rossi, M., Schimpff, S. C., Tattersall, M., Viscoli, C., andthe EORTC Antimicrobial Therapy Cooperative Group Empiric antimicrobial therapy for febrile granulocytopenic cancer patients: lessons from four EORTC trials. Eur. J. Cancer. Clin. Oncol. 24 (Suppl. 1) (1988) 35\u201345.","journal-title":"Eur. J. Cancer. Clin. Oncol."},{"key":"BF01713564_CR6","first-page":"114","volume":"3","author":"G. Maschmeyer","year":"1994","unstructured":"Maschmeyer, G., Link, H., Hiddemann, W., Meyer, P., Helmerking, M., Eisenmann, E., Schmitt, J., Adam, D. Empirische antimikrobielle Therapie bei neutropenischen Patienten. Ergebnisse einer multizentrischen Studie der Arbeitsgruppe Infektionen in der H\u00e4matologie der Paul-Ehrlich-Gesellschaft. Med. Klin. 3 (1994) 114\u2013123.","journal-title":"Med. Klin."},{"key":"BF01713564_CR7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1056\/NEJM198810203191604","volume":"16","author":"J. L. Shenep","year":"1988","unstructured":"Shenep, J. L., Hughes, W. T., Roberson, P. K., Blankenship, K. R., Baker, D. K., Meyer, W. H., Gigliotti, F., Sixbey, J. W., Santana, V. M., Feldmann, S., Lott, L. Vancomycin, ticarcillin and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer. NEJM 16 (1988) 1053\u20131058.","journal-title":"NEJM"},{"issue":"Suppl. 5A","key":"BF01713564_CR8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0002-9343(89)90078-8","volume":"87","author":"K. F. Bayston","year":"1989","unstructured":"Bayston, K. F., Want, S., Cohen, J. A prospective, randomized comparison of ceftazidime and ciprofloxacin as initial empiric therapy in neutropenic patients with fever. Am. J. Med. 87 (Suppl. 5A) (1989) 269\u2013273.","journal-title":"Am. J. Med."},{"key":"BF01713564_CR9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/AAC.36.4.801","volume":"4","author":"J. J. Cornelissen","year":"1992","unstructured":"Cornelissen, J. J., De Graeff, A., Verdonck, L.F., Branger, T., Rozenberg-Arska, M., Verhoef, J., Dekker, A. W. Imipenem versus gentamicin combined with either cefuroxime or cephalothin as initial therapy for febrile neutropenic patients. Antimicrob. Agents Chemother. 4 (1992) 801\u2013807.","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Suppl. A","key":"BF01713564_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/jac\/12.suppl_A.101","volume":"12","author":"V. Fainstein","year":"1983","unstructured":"Fainstein, V., Bodey, G. P., Elting, L., Bolivar, R., Keating, M. J., McCredie, K. B., Valdivieso, M. A randomized study of ceftazidime compared to ceftazidime and tobramycin for the treatment of infections in cancer patients. J. Antimicrob. Chemother. 12 (Suppl. A) (1983) 101\u2013110.","journal-title":"J. Antimicrob. Chemother."},{"key":"BF01713564_CR11","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1128\/AAC.34.7.1336","volume":"7","author":"R. Liang","year":"1990","unstructured":"Liang, R., Yung, R., Chiu, E., Chau, P.-Y., Chan, T.-K., Lam, W.-K., Todd, D. Ceftazidime versus imipenem-cilastatin as initial monotherapy for febrile neutropenic patients. Antimicrob. Agents Chemother. 7 (1990) 1336\u20131341.","journal-title":"Antimicrob. Agents Chemother."},{"key":"BF01713564_CR12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/jac\/31.6.927","volume":"31","author":"S. R. Norrby","year":"1993","unstructured":"Norrby, S. R., Finch, R. G., Glauser, M., anda European Study Group Monotherapy in serious hospital-acquired infections: a clinical trial of ceftazidime versus imipenem\/cilastatin. J. Antimicrob. Chemother. 31 (1993) 927\u2013937.","journal-title":"J. Antimicrob. Chemother."},{"issue":"Suppl.","key":"BF01713564_CR13","first-page":"65","volume":"52","author":"S. R. Norrby","year":"1987","unstructured":"Norrby, S. R., Vandercam, B., Louie, T., Runde, V., Norberg, B., Anniko, M., Anfrien, F., Baudrihaye, M., Bow, E., Burman, A., Bury, J., Ezzedine, H., Gigi, J., Granlund, M., Holm, J., Lundberg, S., Michaux, J.-L., Le Saux, N., Wahlin, A., Zakrisson, E. Imipenem\/cilastatin versus amikacin plus piperacillin in the treatment of infections in neutropenic patients: a prospective, randomized multi-clinic study. Scand. J. Infect. Dis. 52 (Suppl.) (1987) 65\u201378.","journal-title":"Scand. J. Infect. Dis."},{"key":"BF01713564_CR14","first-page":"1323","volume":"18","author":"P. A. Pizzo","year":"1993","unstructured":"Pizzo, P. A. Management of fever in patients with cancer and treatment-induced neutropenia. NEJM 18 (1993) 1323\u20131332.","journal-title":"NEJM"},{"key":"BF01713564_CR15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJM198608283150905","volume":"9","author":"P. A. Pizzo","year":"1986","unstructured":"Pizzo, P. A., Hathorn, J. W., Hiemenz, J., Browne, M., Commers, J., Cotton, D., Gress, J., Longo, D., Marshall, D., McKnight, J., Rubin, M., Skelton, J., Thaler, M., Wesley, R. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. NEJM 9 (1986) 552\u2013558.","journal-title":"NEJM"},{"issue":"Suppl. 5C","key":"BF01713564_CR16","first-page":"85","volume":"80","author":"J. C. Wade","year":"1986","unstructured":"Wade, J. C., Johnson, D., Bustamante, C. I. Monotherapy for empiric treatment of fever in granulocytopenic cancer patients. Am. J. Med. 80 (Suppl. 5C) (1986) 85\u201395.","journal-title":"Am. J. Med."},{"key":"BF01713564_CR17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.7326\/0003-4819-115-11-849","volume":"115","author":"D. J. Winston","year":"1991","unstructured":"Winston, D. J., Ho, W. G., Bruckner, D. A., Champlin, R. E. Betalactam antibiotic therapy in febrile granulocytopenic patients: a randomized trial comparing cefoperazone plus piperacillin, ceftazidime plus piperacillin, and imipenem alone. Ann. Int. Med. 115 (1991) 849\u2013859.","journal-title":"Ann. Int. Med."},{"key":"BF01713564_CR18","first-page":"94","volume":"3","author":"P. M. Shah","year":"1992","unstructured":"Shah, P. M. Resistenzsituation im klinischen Alltag. Arzneimittel-therapie 3 (1992) 94\u201395.","journal-title":"Arzneimittel-therapie"},{"issue":"Suppl.","key":"BF01713564_CR19","first-page":"22","volume":"78","author":"P. M. Shah","year":"1991","unstructured":"Shah, P. M., Asanger, R., Kahan, F. M. Incidence of multi-resistance in gram-negative aerobes from intensive care units of 10 German hospitals. Scand. J. Infect. Dis. 78 (Suppl.) (1991) 22\u201334.","journal-title":"Scand. J. Infect. Dis."},{"key":"BF01713564_CR20","first-page":"366","volume":"130","author":"F. Walther","year":"1989","unstructured":"Walther, F., Fischer, M., Shah, P. M. Therapie von Infektionen bei abwehrgeschw\u00e4chten Patienten mit Imipenem\/Cilastatin. MMW 130 (1989) 366\u2013368.","journal-title":"MMW"},{"key":"BF01713564_CR21","unstructured":"B\u00f6hme, A., Just, G., Bergmann, L., Shah, P., Hoelzer, D., Stille, W.: Cefotaxime\/piperacillin versus imipenem\/cilastatin for initial antimicrobial therapy and early treatment with itraconazole in febrile neutropenic patients. Ann. Hematol. 67 (Suppl.) (1993) abstr. no. 46, A12."},{"issue":"Suppl. 1","key":"BF01713564_CR22","first-page":"37","volume":"34","author":"N. Roos","year":"1991","unstructured":"Roos, N., Fahrenkamp, A., v. Eiff, M., Diederich, S., B\u00f6mmelburg, T., Ritter, J., Fegeler, W., Peters, P. E. Diagnostische Validit\u00e4t bildgebender Verfahren bei Detektion und Verlaufsbeobachtung des gef\u00e4\u00dfinvasiven Aspergillus-Befalls der Lunge. Mycoses 34 (Suppl. 1) (1991) 37\u201341.","journal-title":"Mycoses"},{"key":"BF01713564_CR23","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3109\/00365549109024303","volume":"6","author":"A. S. Dofferhoff","year":"1991","unstructured":"Dofferhoff, A. S., Nijland, J. H., de Vries-Hospers, H. G., Mulder, P. O., Weits, J., Bom, V. J. Effects of different types and combinations of antimicrobial agents on endotoxin release from gram-negative bacteria: anin-vitro andin-vivo study. Scand. J. Infect. Dis. 6 (1991) 745\u2013754.","journal-title":"Scand. J. Infect. Dis."},{"key":"BF01713564_CR24","first-page":"1","volume":"1","author":"P. Meyer","year":"1992","unstructured":"Meyer, P., Adam, D., Hiddemann, W., Link, H., Maschmeyer, G., Helmerking, M. Interventionstherapie von Infektionen und Fieber unklarer Genese bei neutropenischen Patienten mit malignen h\u00e4matologischen Grunderkrankungen. ZAC 1 (1992) 1\u201327.","journal-title":"ZAC"},{"key":"BF01713564_CR25","unstructured":"Silling-Engelhardt, G., Fegeler, W., Roos, N., Schwarz, C., Essink, M., Hiddemann, W., B\u00fcchner, Th.: Interventional treatment of unexplained fever (FUO) and documented infections in neutropenic patients with hematologic malignancies: fluconazole versus ampho B\/5-FC. Ann. Hematol. 64 (Suppl.) (1992) abstr. no. 147, A110."},{"key":"BF01713564_CR26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF01642101","volume":"18","author":"W. Kern","year":"1990","unstructured":"Kern, W., Kurrle, E., Schmeiser, T. Streptococcal bacteremia in adult patient with leukemia undergoing aggressive chemotherapy. A review of 55 Cases. Infection 18 (1990) 138\u2013145.","journal-title":"Infection"},{"key":"BF01713564_CR27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0002-9343(86)90257-3","volume":"81","author":"J. E. Karp","year":"1986","unstructured":"Karp, J. E., Dick, J. D., Angelopulos, C., Charache, P., Green, L., Burke, P. J., Saral, R. Empiric use of vancomycin during prolonged treatment-induced granulocytopenia. Randomized, double-blind, placebo-controlled clinical trial in patients with acute leukemia. Am. J. Med. 81 (1986) 237\u2013242.","journal-title":"Am. J. Med."},{"key":"BF01713564_CR28","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1348-0421.1990.tb01054.x","volume":"34","author":"M. Matsumoto","year":"1990","unstructured":"Matsumoto, M., Matsubara, S., Matsuno, T., Ono, M., Yokota, T. Protective effect of recombinant human granulocyte colony-stimulating factor (rG-CSF) against various microbial infections in neutropenic mice. Microbiol. Immun. 34 (1990) 765\u2013773.","journal-title":"Microbiol. Immun."},{"issue":"Suppl. 1","key":"BF01713564_CR29","first-page":"17","volume":"87","author":"O. G. Ottmann","year":"1994","unstructured":"Ottmann, O. G., Hoelzer, D., Gracien, E., Kelly, K., Ganser, A., Reutzel, R., Lipp, T., Busch, F. W., Schwonzen, M., Wandt, H., Heil, G., Koch, P., Heyll, A., Meyer, P., Bentz, M., Peter, S., Diedrich, H., Kolbe, K., Graf, M. Simultaneous r-metHuG-CSF and chemoradiotherapy during induction treatment in adult ALL: a randomized trial. Br. J. Haematol. 87 (Suppl. 1) (1994) abstr. no. 65, 17.","journal-title":"Br. J. Haematol."},{"key":"BF01713564_CR30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1439-0507.1991.tb00645.x","volume":"34","author":"A. Polak-Wyss","year":"1991","unstructured":"Polak-Wyss, A. Protective effect of human granulocyte colony-stimulating factor (hG-CSF) on cryptococcus and aspergillus infections in normal and immunosuppressed mice. Mycoses 34 (1991) 205\u2013215.","journal-title":"Mycoses"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01713564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF01713564\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01713564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01713564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:44:35Z","timestamp":1744163075000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF01713564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["BF01713564"],"URL":"https:\/\/doi.org\/10.1007\/bf01713564","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]},"assertion":[{"value":"12 January 1995","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 1995","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}