{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:48:02Z","timestamp":1788198482132,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[1994,5]]},"DOI":"10.1007\/bf01720903","type":"journal-article","created":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T00:11:40Z","timestamp":1118621500000},"page":"319-327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Inhaled nitric oxide in acute respiratory failure: Dose-response curves"],"prefix":"10.1007","volume":"20","author":[{"given":"L.","family":"Puybasset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Rouby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mourgeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cluzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arthaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Po\u00e8te","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bodin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Korinek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Viars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01720903_CR1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0140-6736(91)92033-X","volume":"338","author":"J Pepke-Zaba","year":"1991","unstructured":"Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J (1991) Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet 338:1173\u20131174","journal-title":"Lancet"},{"key":"BF01720903_CR2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1097\/00000542-199306000-00004","volume":"78","author":"GF Rich","year":"1993","unstructured":"Rich GF, Murphy GD, Roos CM, Johns RA (1993) Inhaled nitric oxide. Selective pulmonary vasodiation in cardiac surgical patients. Anesthesiology 78:1028\u20131035","journal-title":"Anesthesiology"},{"key":"BF01720903_CR3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1056\/NEJM199302113280605","volume":"328","author":"R Rossaint","year":"1993","unstructured":"Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399\u2013405","journal-title":"N Engl J Med"},{"key":"BF01720903_CR4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF01711084","volume":"19","author":"H Gerlach","year":"1993","unstructured":"Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ (1993) Long-term inhalation with evaluated low doses of nitric oxide for selective improvement in oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 19:443\u2013449","journal-title":"Intensive Care Med"},{"key":"BF01720903_CR5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF01711082","volume":"19","author":"WM Zapol","year":"1993","unstructured":"Zapol WM (1993) Minidose inhaled nitric oxide: less is better. Intensive Care Med 19:433\u2013434","journal-title":"Intensive Care Med"},{"key":"BF01720903_CR6","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","volume":"83","author":"C Frostell","year":"1991","unstructured":"Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM (1991) Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038\u20132047","journal-title":"Circulation"},{"key":"BF01720903_CR7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/00000542-199112000-00011","volume":"75","author":"MD Fratacci","year":"1991","unstructured":"Fratacci MD, Frostell CG, Chen TY, Wain JC, Robinson DR, Zapol WM (1991) Inhaled nitric oxide. A selective pulmonary vasodilator of Heparine-Protamine vasoconstriction in sheep. Anesthesiology 75:990\u2013999","journal-title":"Anesthesiology"},{"key":"BF01720903_CR8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00000542-199303000-00005","volume":"78","author":"CG Frostell","year":"1993","unstructured":"Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM (1993) Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78:427\u2013435","journal-title":"Anesthesiology"},{"key":"BF01720903_CR9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2362.1993.tb00797.x","volume":"23","author":"H Gerlach","year":"1993","unstructured":"Gerlach H, Rossaint R, Pappert D Falke KJ (1993) Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 23:499\u2013502","journal-title":"Eur J Clin Invest"},{"key":"BF01720903_CR10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/138.3.720","volume":"138","author":"JF Murray","year":"1988","unstructured":"Murray JF, Matthay MA, Luce JM, Flick MR (1988) An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138:720\u2013723","journal-title":"Am Rev Respir Dis"},{"key":"BF01720903_CR11","doi-asserted-by":"crossref","unstructured":"Gonzales C, Lejean L, Royer C, Dreux S., Rouby JJ, Viars P (1990) Monitorrage continu et simultan\u00e9 de la PaO2 et de la pression art\u00e9rielle sanglante (1990) Ann Fr Anesth Reanim 9 (Suppl) R2","DOI":"10.1016\/S0750-7658(05)82011-8"},{"key":"BF01720903_CR12","first-page":"A226","volume":"79","author":"JJ Rouby","year":"1993","unstructured":"Rouby JJ, Puybasset L, Mourgeon E, Segal E, Po\u00e8te P, Viars P (1993) Respiratory effects of increasing concentrations of inhaled nitric oxide in patients with ARDS. Anesthesiology 79:A226 (abstract)","journal-title":"Anesthesiology"},{"key":"BF01720903_CR13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/01.CIR.87.2.447","volume":"87","author":"JD Roberts","year":"1993","unstructured":"Roberts JD, Lang P, Bigatello LM, Vlahakes GJ, Zapol WD (1993) Inhaled nitric oxide in congenital heart disease. Circulation 87:447\u2013453","journal-title":"Circulation"},{"key":"BF01720903_CR14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0140-6736(92)92686-A","volume":"340","author":"JD Roberts","year":"1992","unstructured":"Roberts JD, Polaner DM, Lang P, Zapol WD (1992) Inhaled nitric oxide in persistent pulmonary hypertension of the newborn., Lancet 340:818\u2013819","journal-title":"Lancet"},{"key":"BF01720903_CR15","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0140-6736(92)92687-B","volume":"340","author":"JP Kinsella","year":"1992","unstructured":"Kinsella JP, Neish SR, Shaffer E, Abman SH (1992) Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 340:819\u2013820","journal-title":"Lancet"},{"key":"BF01720903_CR16","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/00000542-199211000-00007","volume":"77","author":"C Girard","year":"1992","unstructured":"Girard C, Lehot JJ, Pannetier JC, Filley S, Pfrench P, Estanove S (1992) Inhaled nitric oxide after mitral valve replacement in patient with chronic pulmonary artery hypertension. Anesthesiology 77:880\u2013883","journal-title":"Anesthesiology"},{"key":"BF01720903_CR17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1164\/ajrccm\/148.2.310","volume":"148","author":"S Adnot","year":"1993","unstructured":"Adnot S, Kouyoumdjian C, Deffouilloy C, Andrivet P, Sediame S, Herigault R, Fratacci MD (1993) Hemodynamic and gas exchange response to infusion of acetylcholine and inhalation of nitric oxide in patients with chronic obstructive lung disease and pulmonary hypertension. Am Rev Respir Dis 148:310\u2013316","journal-title":"Am Rev Respir Dis"},{"key":"BF01720903_CR18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1161\/01.RES.72.2.246","volume":"72","author":"JD Roberts","year":"1993","unstructured":"Roberts JD, Chen TY, Kawai N, Wain J, Dupuy P, Shimouchi A, Bloch K, Polaner D, Zapol W (1993) Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res 72:246\u2013254","journal-title":"Circ Res"},{"key":"BF01720903_CR19","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1164\/ajrccm\/147.5.1080","volume":"147","author":"JI Berger","year":"1993","unstructured":"Berger JI, Gibson RL, Redding GJ, Standaert TA, Clarke WR, Truog WE (1993) Effect of inhaled nitric oxide during group B streptococcal sepsis in piglets. Am Rev Respir Dis 147:1080\u20131086","journal-title":"Am Rev Respir Dis"},{"key":"BF01720903_CR20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJM198102263040901","volume":"304","author":"DE Chenoweth","year":"1981","unstructured":"Chenoweth DE, Steven W, Cooper BA, Tony EH, Stewart RW, Blackstone EH, Kirlin JW (1981) Complement activation during cardiopulmonary bypass. N Engl J Med 304:497","journal-title":"N Engl J Med"},{"key":"BF01720903_CR21","first-page":"32","volume":"49","author":"O Ylikorkala","year":"1981","unstructured":"Ylikorkala O, Saarela E, Viinikka L (1981) Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass. J Thorac Cardiovasc Surg 49:32\u201334","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF01720903_CR22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0003-4975(90)90352-7","volume":"49","author":"RW Colman","year":"1990","unstructured":"Colman RW (1990) Platelet and neutrophil activation in cardiopulmonary bypass. Ann Thorac Surg 49:32\u201334","journal-title":"Ann Thorac Surg"},{"key":"BF01720903_CR23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF01705045","volume":"18","author":"J Jahr","year":"1992","unstructured":"Jahr J, Gr\u00e4nde PO (1992) Pulmonary and hemodynamic effects of extracorporeal circulation in the cat and the beneficial effect of prostacyclin. Intensive Care Med 18:118\u2013122","journal-title":"Intensive Care Med"},{"key":"BF01720903_CR24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1164\/ajrccm\/146.3.654","volume":"146","author":"TR Rasmussen","year":"1992","unstructured":"Rasmussen TR, Kjaergaard SK, Tarp U, Pedersen OF (1992) Delayed effects of NO2 exposure on alveolar permeability and glutathione peroxidase in healthy humans. Am Rev Respir Dis 146:654\u2013659","journal-title":"Am Rev Respir Dis"},{"key":"BF01720903_CR25","first-page":"1203","volume":"135","author":"MA Bauer","year":"1986","unstructured":"Bauer MA, Utell MJ, Morrow PE, Spees DM, Gibb FR (1986) 0.30 ppm nitrogen dioxyde inhalation potentiated exercise induced bronchospasm in asthmatics. Am Rev Respir Dis 135:1203\u20131208","journal-title":"Am Rev Respir Dis"},{"key":"BF01720903_CR26","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1164\/ajrccm\/146.2.378","volume":"146","author":"A Ben-Jebria","year":"1992","unstructured":"Ben-Jebria A, Marthan R, Savineau JP (1992) Effect of in vitro nitrogen dioxide exposure on human bronchial smooth muscle response. Am Rev Respir Dis 146:378\u2013382","journal-title":"Am Rev Respir Dis"},{"key":"BF01720903_CR27","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/0140-6736(92)91886-D","volume":"339","author":"L Foubert","year":"1992","unstructured":"Foubert L, Fleming B, Latimer R, Jonas M, Oduro A, Borland C, Higenbottam T (1992) Safety guidelines for use of nitric oxide. Lancet 339:1615\u20131616","journal-title":"Lancet"},{"key":"BF01720903_CR28","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/0140-6736(93)90802-N","volume":"341","author":"M H\u00f6gman","year":"1993","unstructured":"H\u00f6gman M, Frostell C, Arnberg H, hedenstierna G (1993) Bleeding time prolongation and NO inhalation. Lancet 341:1664\u20131665","journal-title":"Lancet"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01720903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF01720903\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01720903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01720903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:25:12Z","timestamp":1744165512000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF01720903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["BF01720903"],"URL":"https:\/\/doi.org\/10.1007\/bf01720903","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]},"assertion":[{"value":"15 September 1993","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 1994","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}