{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:06:12Z","timestamp":1745431572454},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Wochenschr"],"published-print":{"date-parts":[[1984,10]]},"DOI":"10.1007\/bf01728425","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T20:49:32Z","timestamp":1118609372000},"page":"953-962","source":"Crossref","is-referenced-by-count":6,"title":["Inherited disorders of purine metabolism \u2014 Underlying molecular mechanisms"],"prefix":"10.1007","volume":"62","author":[{"given":"W.","family":"Gutensohn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01728425_CR1","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1016\/S0021-9258(18)32431-1","volume":"258","author":"P Argos","year":"1983","unstructured":"Argos P, Hanei M, Wilson JM, Kelley WN (1983) A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases. J Biol Chem 258:6450\u20136457","journal-title":"J Biol Chem"},{"key":"BF01728425_CR2","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1073\/pnas.70.10.2749","volume":"70","author":"MA Becker","year":"1973","unstructured":"Becker MA, Kostel PJ, Meyer LJ, Seegmiller JE (1973) Human phosphoribosylpyrophosphate synthetase: Increased enzyme specific activity in a family with gout and excessive purine synthesis. Proc Natl Acad Sci USA 70:2749\u20132752","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01728425_CR3","unstructured":"Becker MA, Meyer LJ, Kostel PJ, Seegmiller JE (1974) Increased 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase activity and gout: Diversity of structural alterations of the enzyme. J Clin Invest 53:4a (Abstract)"},{"key":"BF01728425_CR4","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.218284","volume":"203","author":"MA Becker","year":"1979","unstructured":"Becker MA, Yen RCK, Itkin P, Goss SJ, Seegmiller JE, Bakay B (1979) Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X-chromosome. Science 203:1016\u20131019","journal-title":"Science"},{"key":"BF01728425_CR5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1172\/JCI109640","volume":"65","author":"MA Becker","year":"1980","unstructured":"Becker MA, Raivio KO, Bakay B, Adams WB, Nyhan WL (1980) Variant human phosphoribosylpyrophosphate synthetase altered in regulatory and catalytic functions. J Clin Invest 65:109\u2013120","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"BF01728425_CR6","first-page":"22","volume":"73","author":"M B\u00f6ck","year":"1984","unstructured":"B\u00f6ck M, M\u00f6ller A, Nees S, Gerlach E (1984) Extrazellul\u00e4rer Abbau von Adeninnukleotiden durch koronare Endothelzellen. Z Kardiol 73 (Suppl 1):22 (Abstract)","journal-title":"Z Kardiol"},{"key":"BF01728425_CR7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.ge.16.120182.001501","volume":"16","author":"GR Boss","year":"1983","unstructured":"Boss GR, Seegmiller JE (1983) Genetic defects in human purine and pyrimidine metabolism. Ann Rev Genet 16:297\u2013328","journal-title":"Ann Rev Genet"},{"key":"BF01728425_CR8","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1016\/S0021-9258(17)44533-9","volume":"258","author":"J Brennand","year":"1983","unstructured":"Brennand J, Konecki DS, Caskey CT (1983) Expression of human and Chinese hamster HGPRT cDNA recombinants in cultured Lesch-Nyhan and Chinese hamster fibroblasts. J Biol Chem 258:9593\u20139596","journal-title":"J Biol Chem"},{"key":"BF01728425_CR9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF00504224","volume":"315","author":"RF Bruns","year":"1980","unstructured":"Bruns RF (1980) Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosine. Arch Pharmacol 315:5\u201313","journal-title":"Arch Pharmacol"},{"key":"BF01728425_CR10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0092-8674(78)90238-6","volume":"14","author":"TS Chan","year":"1978","unstructured":"Chan TS (1978) Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency. Cell 14:523\u2013530","journal-title":"Cell"},{"key":"BF01728425_CR11","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0021-9258(17)34910-4","volume":"253","author":"MS Coleman","year":"1978","unstructured":"Coleman MS, Donofrio J, Hutton JJ, Hahn L, Daoud A, Lampkin B, Dyminski J (1978) Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency. J Biol Chem 253:1619\u20131629","journal-title":"J Biol Chem"},{"key":"BF01728425_CR12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0014-5793(80)80015-9","volume":"110","author":"J Dornand","year":"1980","unstructured":"Dornand J, Bonnafous JC, Mani JC (1980) 5\u2032-Nucleotidase adenylate cyclase relationships in mouse thymocytes. A reevaluation of the effects of concanavalin A on cyclic AMP levels. FEBS Lett 110:30\u201334","journal-title":"FEBS Lett"},{"key":"BF01728425_CR13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2362.1979.tb01665.x","volume":"9","author":"W Gutensohn","year":"1979","unstructured":"Gutensohn W, Jahn H (1979) Partial deficiency of hypoxanthine phosphoribosyltransferase: Evidence for a structural mutation in a patient with gout. Eur J Clin Invest 9:43\u201347","journal-title":"Eur J Clin Invest"},{"key":"BF01728425_CR14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0145-2126(81)90121-1","volume":"5","author":"W Gutensohn","year":"1981","unstructured":"Gutensohn W, Thiel E (1981) High levels of 5\u2032-nucleotidase activity in blastic chronic myelogenous leukemia with common ALL-antigen. Leukemia Res 5:505\u2013510","journal-title":"Leukemia Res"},{"key":"BF01728425_CR15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF01484440","volume":"61","author":"W Gutensohn","year":"1983","unstructured":"Gutensohn W, Thiel E, Emmerich B (1983) Evaluation of 5\u2032-nucleotidase as biochemical marker in leukemias and lymphomas. Klin Wochenschr 61:57\u201362","journal-title":"Klin Wochenschr"},{"key":"BF01728425_CR16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0021-9258(17)30263-6","volume":"254","author":"MS Hershfield","year":"1979","unstructured":"Hershfield MS (1979) Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2\u2032-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine. J Biol Chem 254:22\u201325","journal-title":"J Biol Chem"},{"key":"BF01728425_CR17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI109367","volume":"63","author":"MS Hershfield","year":"1979","unstructured":"Hershfield MS, Kredich NM, Ownby DR, Ownby H, Buckley R (1979) In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2\u2032-deoxyadenosine in adenosine deaminase-deficient patients. J Clin Invest 63:807\u2013811","journal-title":"J Clin Invest"},{"key":"BF01728425_CR18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.123.1.97","volume":"123","author":"JM Johnston","year":"1979","unstructured":"Johnston JM, Kredich NM (1979) Inhibition of methylation by adenosine in adenosine deaminase inhibited phytohemagglutinin-stimulated human lymphocytes. J Immunol 123:97\u2013103","journal-title":"J Immunol"},{"key":"BF01728425_CR19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1073\/pnas.80.2.477","volume":"80","author":"DJ Jolly","year":"1983","unstructured":"Jolly DJ, Okayama H, Berg P, Esty AC, Filpula D, Bohlen P, Johnson GG, Shively JE, Hunkapillar T, Friedmann T (1983) Isolation and characterization of a full length expressible cDNA for human HPRT. Proc Natl Acad Sci USA 80:477\u2013481","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01728425_CR20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4757-0390-0_18","volume-title":"Purine metabolism in man \u2014 IV","author":"N Kamatani","year":"1984","unstructured":"Kamatani N, Kubota M, Willis EH, Frincke LA, Carson DA (1984) 5\u2032-Methylthioadenosine is the major source of adenine in human cells. In: deBruyn CHMM, Simmonds HA, M\u00fcller M (eds) Purine metabolism in man \u2014 IV. Plenum, New York, pp 83\u201388"},{"key":"BF01728425_CR21","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1172\/JCI105913","volume":"47","author":"WN Kelley","year":"1968","unstructured":"Kelley WN, Levy RI, Rosenbloom FM, Henderson JF, Seegmiller JE (1968) APRT deficiency \u2014 A previously undescribed genetic defect in man. J Clin Invest 47:2281\u20132289","journal-title":"J Clin Invest"},{"key":"BF01728425_CR22","first-page":"1115","volume-title":"The metabolic basis of inherited disease","author":"WN Kelley","year":"1983","unstructured":"Kelley WN, Wyngaarden JB (1983) Clinical syndromes associated with hypoxanthine-guanine-phosphoribosyltransferase deficiency. In: Stanbury JB, Wyngaarden JB, Frederickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw Hill, New York, 5th edition, pp 1115\u20131143","edition":"5th edition"},{"key":"BF01728425_CR23","first-page":"1157","volume-title":"The metabolic basis of inherited disease","author":"NM Kredich","year":"1983","unstructured":"Kredich NM, Hershfield MS (1983) Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. In: Stanbury JB, Wyngaarden JB, Frederickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw Hill, New York, 5th edition, pp 1157\u20131183","edition":"5th edition"},{"key":"BF01728425_CR24","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM198111053051902","volume":"305","author":"KG Lloyd","year":"1981","unstructured":"Lloyd KG, Hornykiewicz O, Davidson L, Shannak K, Farley I, Goldstein M, Shibuya M, Kelley WN, Fox IH (1981) Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan-syndrome. New Engl J Med 305:1106\u20131111","journal-title":"New Engl J Med"},{"key":"BF01728425_CR25","first-page":"8","volume":"16","author":"W L\u00f6ffler","year":"1981","unstructured":"L\u00f6ffler W, Gr\u00f6bner W, Z\u00f6llner N (1981) Nutrition and uric acid metabolism: Plasma level, turnover, excretion. Fortschr Urol Nephrol 16:8\u201318","journal-title":"Fortschr Urol Nephrol"},{"key":"BF01728425_CR26","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/BF01540471","volume":"61","author":"W L\u00f6ffler","year":"1983","unstructured":"L\u00f6ffler W, Simmonds HA, Gr\u00f6bner W (1983) Gout and uric acid nephropathy: Some new aspects in diagnosis and treatment. Klin Wochenschr 61:1233\u20131239","journal-title":"Klin Wochenschr"},{"key":"BF01728425_CR27","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1016\/S0021-9258(17)40338-3","volume":"252","author":"LJ Meyer","year":"1977","unstructured":"Meyer LJ, Becker MA (1977) Human erythrocyte phosphoribosylpyrophosphate synthetase. Dependence of activity on state of subunit association. J Biol Chem 252:3919\u20133925","journal-title":"J Biol Chem"},{"key":"BF01728425_CR28","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1073\/pnas.80.15.4709","volume":"80","author":"AD Miller","year":"1983","unstructured":"Miller AD, Jolly DJ, Friedmann T, Verma IM (1983) A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): Gene transfer into cells obtained from humans deficient in HPRT. Proc Natl Acad Sci USA 80:4709\u20134713","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01728425_CR29","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1182\/blood.V56.3.556.556","volume":"56","author":"BS Mitchell","year":"1980","unstructured":"Mitchell BS, Koller CA, Heyn R (1980) Inhibition of adenosine deaminase results in cytotoxicity to T-lymphoblasts in vivo. Blood 56:556\u2013562","journal-title":"Blood"},{"key":"BF01728425_CR30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/978-1-4613-3909-0_22","volume-title":"Regulatory function of adenosine","author":"S Nees","year":"1983","unstructured":"Nees S, Gerlach E (1983) Adenine nucleotide and adenosine metabolism in cultured coronary endothelial cells: Formation and release of adenine compounds and possible functional implications. In: Berne RM, Rall TW, Rubio R (eds) Regulatory function of adenosine. Martinus Nijhoff, The Hague Boston London, pp 347\u2013360"},{"issue":"Suppl 1","key":"BF01728425_CR31","first-page":"22","volume":"73","author":"S Nees","year":"1984","unstructured":"Nees S, B\u00f6ck M, Herzog V, Gerlach E (1984) Perfusion isolierter Herzen mit Adenosin in vasoaktiven Konzentrationen: Selektive Inkorporation in das Koronarendothel. Z Kardiol 73 [Suppl 1]:22 (Abstract)","journal-title":"Z Kardiol"},{"key":"BF01728425_CR32","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1073\/pnas.80.13.4035","volume":"80","author":"RL Nussbaum","year":"1983","unstructured":"Nussbaum RL, Crowder WE, Nyhan WL, Caskey CT (1983) A three-allele restriction-fragment-length polymorphism at the HPRT locus in man. Proc Natl Acad Sci USA 80:4035\u20134039","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01728425_CR33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/bj1900421","volume":"190","author":"JD Pearson","year":"1980","unstructured":"Pearson JD, Carleton JS, Gordon JL (1980) Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth muscle cells in culture. Biochem J 190:421\u2013429","journal-title":"Biochem J"},{"key":"BF01728425_CR34","first-page":"1144","volume-title":"The metabolic basis of inherited disease","author":"HA Simmonds","year":"1983","unstructured":"Simmonds HA, vanAcker KJ (1983) Adenine phosphoribosyltransferase deficiency: 2,8-Dihydroxyadenine lithiasis. In: Stanbury JB, Wyngaarden JB, Frederickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw Hill, New York, 5th edition, pp 1144\u20131156","edition":"5th edition"},{"key":"BF01728425_CR35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0006-2944(72)90017-8","volume":"6","author":"O Sperling","year":"1972","unstructured":"Sperling O, Eilam G, Persky-Brosh S, DeVries A (1972) Accelerated erythrocyte 5-phosphoribosyl-1-pyrophosphate synthesis: A familial abnormality associated with excessive uric acid production and gout. Biochem Med 6:310\u2013314","journal-title":"Biochem Med"},{"key":"BF01728425_CR36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0006-2944(73)90059-8","volume":"7","author":"O Sperling","year":"1973","unstructured":"Sperling O, Persky-Brosh S, Boer P, DeVries A (1973) Human erythrocyte phosphoribosylpyrophosphate synthetase mutationally altered in regulatory properties. Biochem Med 7:389\u2013395","journal-title":"Biochem Med"},{"key":"BF01728425_CR37","first-page":"167","volume":"51","author":"LF Thompson","year":"1981","unstructured":"Thompson LF, Seegmiller JE (1981) Adenosine deaminase deficiency and severe combined immunodeficiency disease. Adv Enzymol 51:167\u2013210","journal-title":"Adv Enzymol"},{"key":"BF01728425_CR38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1073\/pnas.71.1.45","volume":"71","author":"JA Tischfield","year":"1974","unstructured":"Tischfield JA, Ruddle FH (1974) Assignment of the gene for APRT to human chromosome 16 by mouse-human somatic cell hybridization. Proc Natl Acad Sci USA 71:45\u201349","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01728425_CR39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0092-8674(78)90122-8","volume":"14","author":"B Ullman","year":"1978","unstructured":"Ullman B, Gudas LJ, Cohen A, Martin DW (1978) Deoxyadenosine metabolism and cytotoxicity in cultured mouse T-lymphoma cells: A model for immunodeficiency disease. Cell 14:365\u2013375","journal-title":"Cell"},{"key":"BF01728425_CR40","doi-asserted-by":"crossref","first-page":"10306","DOI":"10.1016\/S0021-9258(19)68619-9","volume":"256","author":"JM Wilson","year":"1981","unstructured":"Wilson JM, Baugher BW, Landa L, Kelley WN (1981) Human hypoxanthine-guanine-phosphoribosyltransferase. Purification and characterization of mutant forms of the enzyme. J Biol Chem 256:10306\u201310312","journal-title":"J Biol Chem"},{"key":"BF01728425_CR41","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/S0021-9258(19)68222-0","volume":"257","author":"JM Wilson","year":"1982","unstructured":"Wilson JM, Daddona PE, Simmonds HA, van Acker KJ, Kelley WN (1982) Human adenine phosphoribosyltransferase. Immunochemical quantitation and protein blot analysis of mutant forms of the enzyme. J Biol Chem 257:1508\u20131515","journal-title":"J Biol Chem"},{"key":"BF01728425_CR42","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1016\/S0021-9258(18)33920-6","volume":"257","author":"JM Wilson","year":"1982","unstructured":"Wilson JM, Tarr GE, Mahoney WC, Kelley WN (1982) Human hypoxanthine-guanine-phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme. J Biol Chem 257:10978\u201310985","journal-title":"J Biol Chem"},{"key":"BF01728425_CR43","doi-asserted-by":"crossref","first-page":"14830","DOI":"10.1016\/S0021-9258(18)33358-1","volume":"257","author":"JM Wilson","year":"1982","unstructured":"Wilson JM, Landa LE, Kobayashi R, Kelley WN (1982) Human hypoxanthine-guanine-phosphoribosyltransferase. Tryptic peptides and posttranslational modification of the erythrocyte enzyme. J Biol Chem 257:14830\u201314834","journal-title":"J Biol Chem"},{"key":"BF01728425_CR44","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1172\/JCI111047","volume":"72","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Frossard P, Nussbaum RL, Caskey CT, Kelley WN (1983) Human hypoxanthine guanine-phosphoribosyl-transferase. Detection of a mutant allele by restriction endonuclease analysis. J Clin Invest 72:767\u2013772","journal-title":"J Clin Invest"},{"key":"BF01728425_CR45","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1172\/JCI110884","volume":"71","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Kelley WN (1983) Molecular basis of hypoxanthine-guanine-phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome. J Clin Invest 71:1331\u20131335","journal-title":"J Clin Invest"},{"key":"BF01728425_CR46","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1073\/pnas.80.3.870","volume":"80","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Tarr GE, Kelley WN (1983) Human hypoxanthine-guanine-phosphoribosyltransferase: An amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. Proc Natl Acad Sci USA 80:870\u2013873","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01728425_CR47","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1016\/S0021-9258(18)32432-3","volume":"258","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Kobayashi R, Fox IH, Kelley WN (1983) Human hypoxanthine-guanine-phosphoribosyltransferase. Molecular abnormality in a mutant form of the enzyme (HPRT Toronto). J Biol Chem 258:6458\u20136460","journal-title":"J Biol Chem"},{"key":"BF01728425_CR48","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJM198310133091507","volume":"309","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Young AB, Kelley WN (1983) Hypoxanthine-guanine-phosphoribosyltransferase deficiency. The molecular basis of the clinical syndrome. New Engl J Med 309:900\u2013910","journal-title":"New Engl J Med"},{"key":"BF01728425_CR49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0021-9258(17)43616-7","volume":"259","author":"JM Wilson","year":"1984","unstructured":"Wilson JM, Kelley WN (1984) Human hypoxanthine-guanine-phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRT Munich) isolated from a patient with gout. J Biol Chem 259:27\u201330","journal-title":"J Biol Chem"},{"key":"BF01728425_CR50","first-page":"1043","volume-title":"The metabolic basis of inherited disease","author":"JB Wynngaarden","year":"1983","unstructured":"Wynngaarden JB, Kelley WN (1983) Gout. In: Stanbury JB, Wyngaarden JB, Frederickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw Hill, New York, 5th edition, pp 1043\u20131114","edition":"5th edition"}],"container-title":["Klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01728425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01728425\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01728425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T10:42:56Z","timestamp":1683110576000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01728425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[1984,10]]}},"alternative-id":["BF01728425"],"URL":"https:\/\/doi.org\/10.1007\/bf01728425","relation":{},"ISSN":["0023-2173","1432-1440"],"issn-type":[{"value":"0023-2173","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,10]]}}}