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Compounds labelled with stable isotopes can be used to study enzyme kinetics and substrate turnover, providing more detailed and specific information. Intracellular events may be studied using nuclear magnetic resonance spectroscopy.<\/jats:p><jats:p>The results using these techniques to study patients with selected inborn errors are discussed, namely phenylketonuria, glycogen storage disease type I and propionic acidaemia.<\/jats:p>","DOI":"10.1007\/bf01797925","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T04:48:31Z","timestamp":1119329311000},"page":"546-553","source":"Crossref","is-referenced-by-count":1,"title":["Techniques for studying hepatic metabolism<i>in vivo<\/i>"],"prefix":"10.1002","volume":"14","author":[{"given":"J. V.","family":"Leonard","sequence":"first","affiliation":[{"name":"The Institute of Child Health  London WC1N 1EH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. N.","family":"Thompson","sequence":"additional","affiliation":[{"name":"The Murdoch Institute The Royal Children's Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-9215-3_11"},{"key":"e_1_2_1_3_1","first-page":"19","volume-title":"Inborn Errors of Metabolism","author":"Bartlett K.","year":"1991"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072043"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/2091148a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(82)90142-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799686"},{"key":"e_1_2_1_8_1","volume-title":"Disorders of Carbohydrate Metabolism.","author":"Cornblath M.","year":"1976"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.5.384"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.49.3.186"},{"key":"e_1_2_1_11_1","volume-title":"Nuclear Magnetic Research and Its Application to Living Systems","author":"Gadian D. 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