{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:39:57Z","timestamp":1761154797971},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1990,7,1]],"date-time":"1990-07-01T00:00:00Z","timestamp":646790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Amino acid transport at the mammalian blood\u2010brain barrier has been extensively characterized. Transport of<jats:sc>l<\/jats:sc>\u2010phenylalanine and related neutral amino acids is known to be mediated by a stereospecific, sodium independent, saturable carrier. The affinity of this carrier is much higher than that of comparable systems in other tissues. This feature renders it susceptible to inhibition. It has been suggested that inhibition of neutral amino acid influx into the brain by hyperphenylalaninaemia contributes to the pathophysiology of brain damage in this condition.<\/jats:p><jats:p>Methods for investigation of amino acid transport at the blood\u2010brain barrier are discussed, and current knowledge of blood\u2010brain barrier amino acid transport at the blood\u2010brain barrier is reviewed. Developmental changes are delineated, with particular reference to recent work on the ovine blood\u2010brain barrier.<\/jats:p><jats:p>There is insufficient information concerning blood\u2010brain barrier transport of amino acids in the fetal brain to allow firm conclusions to be drawn concerning implications for treatment of maternal PKU. Reasonable extrapolation from animal data suggests that transport inhibition may contribute to impaired fetal brain growth in maternal PKU, and can be minimized by attempts to maintain a normal milieu from the time of conception.<\/jats:p>","DOI":"10.1007\/bf01799517","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:02:35Z","timestamp":1119362555000},"page":"627-633","source":"Crossref","is-referenced-by-count":16,"title":["Transport of amino acids across the blood\u2010brain barrier: Implications for treatment of maternal phenylketonuria"],"prefix":"10.1002","volume":"13","author":[{"given":"R. M.","family":"Gardiner","sequence":"first","affiliation":[{"name":"Departments of Paediatrics and Human Metabolism University College London, The Rayne Institute  University Street London WC1E 6AU UK"},{"name":"Department of Paediatrics John Radcliffe Hospital  Headington, Oxford OX3 9DU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1990,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp010903"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.211586"},{"key":"e_1_2_1_4_1","volume-title":"The Concept of a Blood\u2010Brain Barrier","author":"Bradbury M. W. 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J. Physiol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90319-8"},{"key":"e_1_2_1_24_1","unstructured":"Yudilevich D. L. Wheeler C. P. D.andBustamante J. C.A comparative view of amino acid transport across the blood\u2010brain barrier (endothelium) and the placenta (trophoblast). In:Proceedings of Symposium on Peptide and Amino Acid Transport Mechanisms in the Central Nervous System (In press)."}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01799517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01799517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T02:46:09Z","timestamp":1694918769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01799517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["10.1007\/BF01799517"],"URL":"https:\/\/doi.org\/10.1007\/bf01799517","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}