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Thus, the genes causing X\u2010linked hypophosphataemic rickets, Lowe syndrome, X\u2010linked recessive hypoparathyroidism, Di George syndrome, multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2 and vitamin D\u2010dependent rickets type I have been mapped. In addition the genes involved in the pathogenesis of the humoral hypercalcaemia of malignancy, vitamin D\u2010dependent rickets type II, pseudohypoparathyroidism, and some of the autosomal forms of hypoparathyroidism have been cloned and the mutations characterized. The molecular and genetic studies which have mapped and identified these disease genes are described and the implications of these developments in clinical practice and in further elucidation of the mineral metabolic defects are discussed.<\/jats:p>","DOI":"10.1007\/bf01799617","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:25:03Z","timestamp":1119374703000},"page":"592-609","source":"Crossref","is-referenced-by-count":7,"title":["Molecular genetics of mineral metabolic disorders"],"prefix":"10.1002","volume":"15","author":[{"given":"R. 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