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Electrophoretic analysis of collagen \u03b1\u2010chains, as well as one\u2010 and two\u2010dimensional electrophoresis of collagen cyanogen bromide peptides, failed to show any evidence of primary structure defects or overmodification of lysine residues in these collagens. The proportion of hydroxylated prolyl residues in isolated \u03b11(I) chains was also normal. There was a minimal increase in the proportion of type III collagen produced by nine cultures. The findings in this study indicate that the underlying molecular defects in the patients studied are unlikely to involve the structure of the main fibrillar type I and III collagens.<\/jats:p>","DOI":"10.1007\/bf01799689","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T13:55:56Z","timestamp":1119362156000},"page":"219-226","source":"Crossref","is-referenced-by-count":3,"title":["Marfan syndrome: Absence of type I or III collagen structural defects in 25 patients"],"prefix":"10.1002","volume":"13","author":[{"given":"V. R.","family":"Harley","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Genetics Royal Children's Hospital  Flemington Rd Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. G.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria 3052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1989,8,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2170103"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2400699"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48196-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7745"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.3.173"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1970377"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)57243-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292673"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.24.3.148"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290233"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01477287"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240270210"},{"key":"e_1_2_1_14_1","first-page":"211A","article-title":"Marfan syndrome: abnormality of the microfibrillar array","volume":"35","author":"Hollister D. W.","year":"1987","journal-title":"Clin. Res."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1987.tb01239.x"},{"key":"e_1_2_1_16_1","first-page":"1071","article-title":"Segregation of all four major fibrillar collagen genes in the Marfan syndrome","volume":"41","author":"Ogilvie D. J.","year":"1987","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"Phillips C. L. Shrago A. W. Pinnell S. R.andWenstrup R. J.DNA sequence analysis of alpha 2(I) collagen from an individual with the Marfan phenotype.Ann. NY Acad. 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Genet."}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01799689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01799689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T05:14:14Z","timestamp":1694927654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01799689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8,31]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1007\/BF01799689"],"URL":"https:\/\/doi.org\/10.1007\/bf01799689","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8,31]]}}}