{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T04:57:47Z","timestamp":1694840267666},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1995,7,6]],"date-time":"1995-07-06T00:00:00Z","timestamp":804988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hyperprostaglandin E syndrome is a rare disease usually presenting with renal symptoms such as polyuria, polyhydramnios, hypercalciuria, hypokalaemia, and recurrent episodes of extreme fever, diarrhoea, and convulsions. We report a severe variant of this syndrome with obvious pain and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>)\u2010stimulated hyperthyroidism, an association not previously described. Urinary excretion of PGE<jats:sub>2<\/jats:sub> and its metabolite 7<jats:italic>\u03b1<\/jats:italic>\u2010hydroxy\u20105,11\u2010diketotetranorprosta\u20101,16\u2010dioic acid were markedly increased above normal levels (to 53.3 and 1895 ng\/h per 1.73 m<jats:sup>2<\/jats:sup>, respectively). We studied oxidative capacity of peroxisomes and mitochondria, the sites where PGE<jats:sub>2<\/jats:sub> oxidation takes place. A generalized mitochondrial disease could be ruled out and no deficiency was found in liver peroxisomal oxidases. The basic pathology of hyperprostaglandin E syndrome remains unsolved.<\/jats:p>","DOI":"10.1007\/bf01799846","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T16:38:06Z","timestamp":1119371886000},"page":"687-694","source":"Crossref","is-referenced-by-count":0,"title":["Severe hyperprostaglandin E syndrome with hyperthyroidism \u2014 studies of pathogenetic mechanisms"],"prefix":"10.1002","volume":"19","author":[{"given":"V.","family":"Fellman","sequence":"first","affiliation":[{"name":"Children's Hospital, University of Helsinki  Stenb\u00e4ckinkatu 11 Helsinki 00290 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pihko","sequence":"additional","affiliation":[{"name":"Children's Hospital, University of Helsinki  Stenb\u00e4ckinkatu 11 Helsinki 00290 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Majander","sequence":"additional","affiliation":[{"name":"Helsinki Bioenergetics Group, Institute of Biomedical Sciences, Department of Medical Chemistry University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Seyberth","sequence":"additional","affiliation":[{"name":"Children's Hospital University of Marburg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,7,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"F377","article-title":"Segmental synthesis and actions of prostaglandins along the nephron","volume":"253","author":"Bonvcalet J\u2010P","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1270197"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.251"},{"key":"e_1_2_1_5_1","first-page":"G23","article-title":"Studies in vivo and in vitro on effects of PGE2 on colonic motility in rabbits","volume":"262","author":"Burakoff R","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199410000-00006"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82480-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104637"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199110000-00007"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38254-6"},{"key":"e_1_2_1_11_1","first-page":"696","article-title":"Thyrotoxic hypokalemic periodic paralysis following second\u2010trimester prostaglandin\u2010induced abortion","volume":"82","author":"Richey SD","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90043-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496408"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80395-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199301000-00019"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2058-7_12"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)52454-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1989.tb01420.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54283-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)88666-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82206-2"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01799846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01799846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:44:10Z","timestamp":1694778250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01799846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7,6]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["10.1007\/BF01799846"],"URL":"https:\/\/doi.org\/10.1007\/bf01799846","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7,6]]}}}