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The plot of Phe\/Tyr (micromolar ratio) against Phe<jats:sup>2<\/jats:sup>\/Tyr, permitted the detection of 11 heterozygotes among 209 controls. The accuracy of this method was checked by computation of a stepwise multivariate discriminant analysis, using Phe and Tyr (<jats:italic>\u00b5<\/jats:italic>mol\/L), Phe\/Tyr micromolar ratio and Phe<jats:sup>2<\/jats:sup>\/Tyr as variables. Ten of the 11 subjects were recovered with a percentage of correct classification of over 90%, while one case had a percentage of 89.45%. The PKU gene frequency was found to be 1\/19. This emphasizes the importance of a screening programme for PKU gene carrier status in Turkey.<\/jats:p>","DOI":"10.1007\/bf01799943","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:16:34Z","timestamp":1119374194000},"page":"741-748","source":"Crossref","is-referenced-by-count":6,"title":["Heterozygous carriers of classical phenylketonuria in a sample of the turkish population: Detection by a spectrofluorimetric method"],"prefix":"10.1002","volume":"14","author":[{"given":"F.","family":"G\u00fcneral","sequence":"first","affiliation":[{"name":"Institute of Child Health, Department of Pediatric Nutrition and Metabolism Hacettepe University  Ankara 06100 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130.","family":"\u00d6zalp","sequence":"additional","affiliation":[{"name":"Institute of Child Health, Department of Pediatric Nutrition and Metabolism Hacettepe University  Ankara 06100 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tatlidil","sequence":"additional","affiliation":[{"name":"Department of Statistics Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1990,8,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90020-3"},{"key":"e_1_2_1_3_1","first-page":"1180","article-title":"Carrier screening for phenylketonuria: comparison of two discriminant analysis procedures","volume":"36","author":"Freehauf C. 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