{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:18:13Z","timestamp":1790065093512,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1990,9,24]],"date-time":"1990-09-24T00:00:00Z","timestamp":654134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We describe agoraphobia as a complication of phenylketonuria (PKU) in young adults. The five patients have classic PKU and received phenylalanine\u2010restricted diet only in childhood. Only one has normal intelligence. All but one were also depressed. All were anxious. Three of the five had initiated the phenylalanine\u2010restricted diet after 3 months of age. Two returned to the phenylalanine\u2010restricted diet with dramatic reduction of symptoms.<\/jats:p><jats:p>The frequency of manifestations of agoraphobia was also examined in 50 young women with PKU enrolled in a longitudinal study of psychosocial factors in maternal PKU, 47 of their acquaintances and 49 women with diabetes. All were administered a test of agoraphobic\u2010avoidant behaviour. The women with PKU appeared to be more prone to social withdrawal and fear of leaving home. Twenty per cent were within the agoraphobia range of the Mobility Inventory. Those still on diet and those with non\u2010PKU hyperphenylalaninaemia reported less avoidant behaviour than those who had terminated the diet in childhood.<\/jats:p><jats:p>These results suggest that young adults with PKU are at risk for agoraphobia but that return to the phenylalanine\u2010restricted diet may be an effective treatment.<\/jats:p>","DOI":"10.1007\/bf01799946","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:16:34Z","timestamp":1119374194000},"page":"755-764","source":"Crossref","is-referenced-by-count":43,"title":["Agoraphobia in phenylketonuria"],"prefix":"10.1002","volume":"14","author":[{"given":"S. E.","family":"Waisbren","sequence":"first","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,9,24]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1979.tb01623.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01183861"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014669"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90140-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800110045006"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1542\/peds.83.3.449","article-title":"Newborn screening fact sheets","volume":"83","author":"Committee on Genetics, American Academy of Pediatrics","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_1","volume-title":"The Rorschach: A Comprehensive System","author":"Exner J. 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