{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:02:55Z","timestamp":1789131775281,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1991,10,7]],"date-time":"1991-10-07T00:00:00Z","timestamp":686793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1992,9]]},"abstract":"Summary<\/jats:title>The allopurinol challenge test was performed on 44 healthy subjects (28 children and 16 adolescents) in order to establish normal values of urinary orotic acid excretion following allopurinol ingestion in the paediatric population. The subjects were divided into three groups according to their age: 6 months to 6 years; 6 years to 10 years; and 10 years to 17 years. They were given 100 mg, 200 mg, or 300 mg of allopurinol, respectively (based on age) in a single oral dose. Maximum peak urinary orotic acid levels following ingestion of allopurinol were 13.0 (n<\/jats:italic>=14), 9.3 (n<\/jats:italic>=14), and 10.2 (n<\/jats:italic>=16) \u00b5mol\/mmol creatinine in the three groups, respectively. In all children tested the peak orotic acid level was 3.1\u00b12.7 \u00b5mol\/mmol creatinine (mean \u00b1 SD,n<\/jats:italic>=44). This allopurinol challenge test was also performed in six children with ureacycle disorders, including five females with ornithine transcarbamylase (OTC) deficiency, all of whom demonstrated abnormally elevated levels of urinary orotic acid (peak levels of 26\u2013134 \u00b5mol\/mmol creatinine) following allopurinol ingestion.<\/jats:p>","DOI":"10.1007\/bf01800010","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:20:51Z","timestamp":1119374451000},"page":"707-712","source":"Crossref","is-referenced-by-count":39,"title":["Allopurinol challenge test in children"],"prefix":"10.1002","volume":"15","author":[{"given":"A. B.","family":"Burlina","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dionisi\u2010Vici","sequence":"additional","affiliation":[{"name":"Department of Metabolism Bambino Gesu Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bordugo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zacchello","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tuchman","sequence":"additional","affiliation":[{"name":"Division of Genetics and Metaboilsm, Departments of Pediatrics and Laboratory Medicine and Pathology University of Minnesota Box 400 Mayo Memorial Building, 420 Delaware Street, SE Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1991,10,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01846026"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01805599"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108800"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(89)80009-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3933.861"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/26.3.473"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222305"},{"key":"e_1_2_1_9_1","first-page":"115","volume-title":"Practical Physiological Chemistry","author":"Hawk PB","year":"1947"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80606-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198102000-00006"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02613-7_1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198512000-00016"},{"key":"e_1_2_1_14_1","first-page":"1095","volume-title":"The Metabolic Basis of Inherited Disease","author":"Suttle DP","year":"1989"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530100104022"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(73)90883-1"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01800010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01800010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:32:55Z","timestamp":1694878375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01800010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10,7]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1007\/BF01800010"],"URL":"https:\/\/doi.org\/10.1007\/bf01800010","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10,7]]}}}