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The phenylketonuric and hyperphenylalaninaemic individuals taking the non\u2010supplemented amino acid mixture generally had lower levels: 36% were below the normal range as defined by our laboratory, compared with 19% in the supplemented group. The low levels were present even in those on diet, who had a greater phenylalanine tolerance \u2014 that is, a tolerance for more than 9\u00d750 mg phenylalanine exchanges per day, in other words a higher intake of natural protein. Individuals on long\u2010term synthetic diets may be at risk for selenium deficiency even on selenium supplements. In areas where the soil may be low in selenium, the deficiency may be aggravated. Long\u2010term low levels may impair health but the required amount of selenium supplementation remains uncertain.<\/jats:p>","DOI":"10.1007\/bf01800019","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:20:51Z","timestamp":1119374451000},"page":"769-773","source":"Crossref","is-referenced-by-count":30,"title":["Serum selenium levels in individuals on PKU diets"],"prefix":"10.1002","volume":"15","author":[{"given":"G.","family":"Darling","sequence":"first","affiliation":[{"name":"The Children's Hospital  Temple Street Dublin 1 Eire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mathias","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Dublin Institute of Technology  Kevin Street Dublin, 8 Eire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"O'Regan","sequence":"additional","affiliation":[{"name":"Department of Statistics Trinity College  Dublin Eire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Naughten","sequence":"additional","affiliation":[{"name":"The Children's Hospital  Temple Street Dublin 1 Eire"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,1,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/41.6.1193"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1966.tb72571.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.5.1066"},{"key":"e_1_2_1_5_1","first-page":"354","article-title":"Acute selenium poisoning. 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