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This review of the literature also contains novel observations about the following syndromes: cerebro\u2010hepato\u2010renal (Zellweger) syndrome, X\u2010linked and neonatal adrenoleukodystrophies (ALD, NALD), NALD\u2010like syndromes, infantile phytanic acid storage, classical Refsum disease, rhizomelic and other forms of chondrodysplasia punctata (XD, XR, AR), hyperpipecolic acidaemia, primary hyperoxaluria I, pseudo\u2010Zellweger and Zellweger\u2010like syndromes, and single enzyme deficiencies. Microscopic data include catalase staining and morphometry of peroxisomes, immunolocalization of<jats:italic>\u03b2<\/jats:italic>\u2010oxidation enzymes, detection of trilamellar, polarizing inclusions in PAS\u2010positive macrophages, fibrosis and iron storage. Peroxisomal enlargement appears to be related to functional deficit in<jats:italic>\u03b2<\/jats:italic>\u2010oxidation disorders as well as in rhizomelic chondrodysplasia punctata. Because normal peroxisomal localization of active<jats:italic>\u03b2<\/jats:italic>\u2010oxidation enzymes can accompany a C<jats:sub>26<\/jats:sub><jats:italic>\u03b2<\/jats:italic>\u2010oxidation deficit, other mechanisms such as impaired transport of metabolites should be investigated. \u2018Ghost\u2019\u2010like organelles are shown in the liver of an infantile Refsum patient and in an NALD\u2010like case; immuno\u2010gold labelling of membrane proteins did not reveal ghosts in Zellweger livers.<\/jats:p>","DOI":"10.1007\/bf01800464","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:04:17Z","timestamp":1119373457000},"page":"853-875","source":"Crossref","is-referenced-by-count":65,"title":["Liver pathology and immunocytochemistry in congenital peroxisomal diseases: a review"],"prefix":"10.1002","volume":"14","author":[{"given":"F.","family":"Roels","sequence":"first","affiliation":[{"name":"Human Anatomy and Embryology, Faculty of Medicine and Pharmacy Vrije Unversiteit Brussel  Laarbeeklaan 103 Brussels 1090 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Espeel","sequence":"additional","affiliation":[{"name":"Human Anatomy and Embryology, Faculty of Medicine and Pharmacy Vrije Unversiteit Brussel  Laarbeeklaan 103 Brussels 1090 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"De Craemer","sequence":"additional","affiliation":[{"name":"Human Anatomy and Embryology, Faculty of Medicine and Pharmacy Vrije Unversiteit Brussel  Laarbeeklaan 103 Brussels 1090 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1991,3,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"57","article-title":"Estimation of the mean size of spheres from the profiles in ultrathin sections: A stereological method","volume":"32","author":"Abe K.","year":"1983","journal-title":"J. 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