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This supply must be increased in association with increased ATP turnover.<\/jats:p><jats:p>We have shown that ATP turnover continuously supplies hypoxanthine for recycling by the enzyme HPRT and that this supply increases curvilinearly with increasing ATP turnover. The effects of increasing exercise on ATP turnover were examined using a Latin square experimental design. The outputs of hypoxanthine, xanthine, urate and creatinine were measured. The data were then examined statistically.<\/jats:p>","DOI":"10.1007\/bf01800592","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:15:11Z","timestamp":1119374111000},"page":"202-214","source":"Crossref","is-referenced-by-count":6,"title":["The pathogenesis of the Lesch\u2010Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase"],"prefix":"10.1002","volume":"14","author":[{"given":"R. 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