{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:48:21Z","timestamp":1760975301045},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deficiency of ornithine transcarbamylase (OTC, EC 2.1.3.3) (McKusick 31125), a mitochondrial enzyme of the urea cycle, appears to be one of the most frequent causes of inherited ammonia intoxication, and evidence indicates that the enzyme is X\u2010linked. Recently, different kinds of mutation have been reported (Cathelineau<jats:italic>et al.<\/jats:italic>, 1972; Briand<jats:italic>et al.<\/jats:italic>, 1982). We carried out detailed studies on the molecular properties of the enzyme from two heterozygous females, using an antibody to bovine OTC which cross\u2010reacted with the human enzyme.<\/jats:p>","DOI":"10.1007\/bf01801772","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:54:31Z","timestamp":1119916471000},"page":"131-132","source":"Crossref","is-referenced-by-count":5,"title":["Immunochemical study of ornithine transcarbamylase deficiency"],"prefix":"10.1002","volume":"7","author":[{"given":"H.","family":"Kodama","sequence":"first","affiliation":[{"name":"Department of Pediatrics Jichi Medical School  Minamikawachi\u2010machi Kawachi\u2010gun, Tochigi\u2010ken 329\u201004 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical School  Minamikawachi\u2010machi Kawachi\u2010gun, Tochigi\u2010ken 329\u201004 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Shimoizumi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical School  Minamikawachi\u2010machi Kawachi\u2010gun, Tochigi\u2010ken 329\u201004 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical School  Minamikawachi\u2010machi Kawachi\u2010gun, Tochigi\u2010ken 329\u201004 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kamoshita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical School  Minamikawachi\u2010machi Kawachi\u2010gun, Tochigi\u2010ken 329\u201004 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(82)90136-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(72)90525-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(83)90005-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45528-2"},{"key":"e_1_2_1_6_1","first-page":"325","volume-title":"The Urea Cycle","author":"Nuzum C. T.","year":"1976"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01801772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01801772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:36:01Z","timestamp":1694878561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01801772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1007\/BF01801772"],"URL":"https:\/\/doi.org\/10.1007\/bf01801772","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}