{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:43:28Z","timestamp":1694778208218},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The streptozotocin\u2010treated diabetic rat was not found to be a suitable animal model for methylmalonic acidaemia as previously described. Urinary methylmalonic acid (MMA) was measured in adult Wistar rats prior to and following injection of streptozotocin (40 mg\/kg). Plasma and tissue MMA levels were measured following the induction of diabetes and compared with data from control rats. MMA levels were determined by a gas chromatographic\u2010mass spectrometric method (McMurray<jats:italic>et al.<\/jats:italic>, 1986). Diabetes was confirmed by the 10 \u00d7 increase in 24h urine volume; glycosuria; glycaemia; and weight loss. Urinary MMA excreted did not change during the 11 week diabetic period and there was no difference between the pre\u2010 and post\u2010diabetic phases (<jats:italic>p<\/jats:italic>&lt;0.05). Plasma and tissue MMA concentrations were not elevated in this diabetic animal model. Also in contrast to earlier reports, the vitamin B<jats:sub>12<\/jats:sub> levels of the diabetic rats were not elevated compared to controls (<jats:italic>p<\/jats:italic>&lt;0.05).<\/jats:p>","DOI":"10.1007\/bf01802038","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:58:04Z","timestamp":1119916684000},"page":"429-435","source":"Crossref","is-referenced-by-count":1,"title":["Streptozotocin\u2010induced diabetes is not a model for methylmalonic acidaemia"],"prefix":"10.1002","volume":"12","author":[{"given":"L. B.","family":"Bailey","sequence":"first","affiliation":[{"name":"Food Science and Human Nutrition Department University of Florida  Gainesville FL 32611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Molloy","sequence":"additional","affiliation":[{"name":"Biochemistry Department Trinity College  Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Scott","sequence":"additional","affiliation":[{"name":"Biochemistry Department Trinity College  Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rice","sequence":"additional","affiliation":[{"name":"Veterinary Research Laboratories, Stormont  Belfast BTU 3SD Northern Ireland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1966.tb03209.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(72)90432-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01810356"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90018-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90599-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(69)90108-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90631-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1966.tb02383.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.1.52"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.180605"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10551.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90440-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)80713-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/100.8.935"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3855.805"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"Sundberg A.andGronberg A.Diabetes mellitus and pernicious anaemia.Acta Med. Scand. \u2018H\u2019 1966 (1960)147\u2013150..","DOI":"10.1111\/j.0954-6820.1960.tb17365.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.121.20.472"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456326900600108"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5331.676-a"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19690041"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01802038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01802038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T01:00:59Z","timestamp":1694739659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01802038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["10.1007\/BF01802038"],"URL":"https:\/\/doi.org\/10.1007\/bf01802038","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}