{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:16:36Z","timestamp":1761707796784},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Tr"],"published-print":{"date-parts":[[1996,2]]},"DOI":"10.1007\/bf01803788","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T00:18:51Z","timestamp":1119917931000},"page":"97-108","source":"Crossref","is-referenced-by-count":44,"title":["Breast cancer angiogenesis \u2014 new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting"],"prefix":"10.1007","volume":"38","author":[{"given":"Adrian L.","family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huatang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prudence","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Pattison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Gatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Stratford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Bicknell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01803788_CR1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","volume":"82","author":"JJ Folkman","year":"1990","unstructured":"Folkman JJ: What is the evidence that tumours are angiogenesis dependent? J Natl Cancer Inst 82:4\u20136, 1990","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR2","first-page":"89","volume":"1032","author":"CH Blood","year":"1990","unstructured":"Blood CH, Zetter BR: Tumour interactions with the vasculature: angiogenesis and tumour metastasis. Biochim Biophys Acta, 1032:89\u2013118, 1990","journal-title":"Biochim Biophys Acta"},{"key":"BF01803788_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/365267a0","volume":"365","author":"M Nguyen","year":"1993","unstructured":"Nguyen M, Strubel NA, Bischoff J: A role for sialyl Lewis-X\/A glycoconjugates in capillary morphogenesis. Nature 365:267\u2013269, 1993","journal-title":"Nature"},{"key":"BF01803788_CR4","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/0140-6736(92)92039-I","volume":"339","author":"IR Hart","year":"1992","unstructured":"Hart IR, Saini A: Biology of tumour metastasis. Lancet 339:1453\u20131457, 1992","journal-title":"Lancet"},{"key":"BF01803788_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","volume":"324","author":"N Weidner","year":"1991","unstructured":"Weidner N, Semple JP, Welch WR, Folkman J: Tumour angiogenesis and metastasis \u2014 correlation in invasive breast carcinoma. New Engl J Med 324:1\u20138, 1991","journal-title":"New Engl J Med"},{"key":"BF01803788_CR6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/oxfordjournals.annonc.a058829","volume":"5","author":"PS Craft","year":"1994","unstructured":"Craft PS, Harris AL: Clinical prognostic significance of tumour angiogenesis. Ann Oncol 5:305\u2013311, 1994","journal-title":"Ann Oncol"},{"key":"BF01803788_CR7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0889-8588(18)30187-4","volume":"8","author":"DF Hayes","year":"1994","unstructured":"Hayes DF: Angiogenesis and breast cancer. Hematol Oncol Clin North Am 8:51\u201371, 1994","journal-title":"Hematol Oncol Clin North Am"},{"key":"BF01803788_CR8","first-page":"2641","volume":"48","author":"RK Jain","year":"1988","unstructured":"Jain RK: Determinants of tumour blood flow: a review. Cancer Res 48:2641\u20132658, 1988","journal-title":"Cancer Res"},{"key":"BF01803788_CR9","first-page":"265","volume":"51","author":"Jr Less","year":"1991","unstructured":"Less JR, Skalak TC, Sevick EM, Jain RK: Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions. Cancer Res 51:265\u2013273, 1991","journal-title":"Cancer Res"},{"key":"BF01803788_CR10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/09553009414550121","volume":"65","author":"IJ Stratford","year":"1994","unstructured":"Stratford IJ, Adams GE, Bremner J, Cole S, Edwards HS, Robertson N, Wood PJ: Manipulation and exploitation of the tumor environment for therapeutic benefit. Int J Radiat Biol 65:85\u201394, 1994","journal-title":"Int J Radiat Biol"},{"key":"BF01803788_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/09553009414550131","volume":"65","author":"JM Brown","year":"1994","unstructured":"Brown JM, Giaccia AJ: Tumour hypoxia: the picture has changed in the 1990's. Int J Radiat Biol 65:95\u2013102, 1994","journal-title":"Int J Radiat Biol"},{"key":"BF01803788_CR12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1259\/0007-1285-66-783-181","volume":"66","author":"J Denekamp","year":"1993","unstructured":"Denekamp J: Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy. Br J Radiol 66:181\u2013196, 1993","journal-title":"Br J Radiol"},{"key":"BF01803788_CR13","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1093\/annonc\/5.suppl_4.S45","volume":"5","author":"R Bicknell","year":"1994","unstructured":"Bicknell R: Vascular targeting and the inhibition of angiogenesis. Ann Oncol 5:S45-S50, 1994","journal-title":"Ann Oncol"},{"key":"BF01803788_CR14","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.1073\/pnas.90.19.8996","volume":"90","author":"F Burrows","year":"1993","unstructured":"Burrows F, Thorpe P: Eradication of large solid tumours in mice with an immunotoxin directed against tumour vasculature. Proc Natl Acad Sci USA 90: 8996\u20139000, 1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01803788_CR15","unstructured":"Harris AL, Fox S, Bicknell R, Relf M, Lejeune S, Gatter K, Leek R: Breast cancer angiogenesis: Major independent prognostic factor in node negative breast cancer, regulation by multiple angiogenic factors [Abstract #1106]. Proc AACR, 85th Annual Meeting, Vol 25, 1994"},{"key":"BF01803788_CR16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/348555a0","volume":"348","author":"D Ingber","year":"1990","unstructured":"Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamara T, Brem H, Folkman J: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348:555\u2013557, 1990","journal-title":"Nature"},{"key":"BF01803788_CR17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/jnci\/83.10.716","volume":"83","author":"A Wellstein","year":"1991","unstructured":"Wellstein A, Zugmaier G, Califano JA, Kern F, Paik S, Lippman ME: Tumour growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate. J Natl Cancer Inst 83:716\u2013720, 1991","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR18","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/jnci\/84.22.1716","volume":"84","author":"G Zugmaier","year":"1992","unstructured":"Zugmaier G, Lippman ME, Wellstein A: Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals. J Natl Cancer Inst 84: 1716\u20131724, 1992","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0959-8049(94)90087-6","volume":"30A","author":"G Gasparini","year":"1994","unstructured":"Gasparini G, Harris AL: Does improved control of tumour growth require an anticancer therapy targeting both neoplastic and intratumoral endothelial cells? Eur J Cancer 30A:201\u2013206, 1994","journal-title":"Eur J Cancer"},{"key":"BF01803788_CR20","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/0140-6736(92)93150-L","volume":"340","author":"ER Horak","year":"1992","unstructured":"Horak ER, Leek R, Klenk N, LeJeune S, Smith K, Stuart N, Greenall M, Stepniewska K, Harris AL: Angiogenesis, assessed by platelet\/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340:1120\u20131124, 1992","journal-title":"Lancet"},{"key":"BF01803788_CR21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/jcp.45.2.143","volume":"45","author":"I Kuzu","year":"1992","unstructured":"Kuzu I, Bicknell R, Harris AL, Jones M, Gatter KC, Mason DY: Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours. J Clin Pathol 45:143\u2013148, 1992","journal-title":"J Clin Pathol"},{"key":"BF01803788_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.1993.tb17192.x","volume":"698","author":"ER Horak","year":"1993","unstructured":"Horak ER, Harris AL, Stuart N, Bicknell R: Angiogenesis in breast cancer: regulation, prognostic aspects and implications for novel treatment strategies. Ann NY Acad Sci 698:71\u201384, 1993","journal-title":"Ann NY Acad Sci"},{"key":"BF01803788_CR23","first-page":"322","volume":"69","author":"I Kuzu","year":"1993","unstructured":"Kuzu I, Bicknell R, Fletcher CDH, Gatter KC: The expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumours. Lab Invest 69:322\u2013328, 1993","journal-title":"Lab Invest"},{"key":"BF01803788_CR24","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/jnci\/84.24.1875","volume":"84","author":"N Weidner","year":"1992","unstructured":"Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini GJ: J Natl Cancer Inst 84:1875\u20131887, 1992","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR25","first-page":"155","volume":"4","author":"G Gasparini","year":"1994","unstructured":"Gasparini G, Bevilacqua P, Boracchi P, Maluta S, Pozza F, Barbareschi M, Palma PD, Mezzetti M, Harris AL: Prognostic value of p53 expression in early stage breast carcinoma compared with tumour angiogenesis, epidermal growth factor receptor, c-erbB-2, cathepsin D, DNA ploidy, parameters of cell kinetics and conventional features. Int J Oncol 4: 155\u2013162, 1994","journal-title":"Int J Oncol"},{"key":"BF01803788_CR26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1200\/JCO.1994.12.3.454","volume":"12","author":"G Gasparini","year":"1994","unstructured":"Gasparini G, Weidner N, Bevilacqua P, Maluta S, Salla PP, Caffo O, Barbareschi M, Marubini E, Pozza FJ: Clin Oncol 12:454\u2013466, 1994","journal-title":"Clin Oncol"},{"key":"BF01803788_CR27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0046-8177(92)90344-3","volume":"23","author":"S Bosari","year":"1992","unstructured":"Bosari S, Lee A, De Lellis D, Wiley B, Heatley G, Silverman M: Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 23:755\u2013761, 1992","journal-title":"Hum Pathol"},{"key":"BF01803788_CR28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ijc.2910550305","volume":"55","author":"M Toi","year":"1993","unstructured":"Toi M, Kashitani J, Tominaga T: Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int J Cancer 55:371\u2013374, 1993","journal-title":"Int J Cancer"},{"key":"BF01803788_CR29","first-page":"47","volume":"4","author":"HJ Chalkley","year":"1943","unstructured":"Chalkley HJ: Method for the quantitative morphological analysis of tissues. J Natl Cancer Inst 4:47\u201353, 1943","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR30","unstructured":"Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC, Harris AL: Quantitation and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chalkley count and computer image analysis. In press."},{"key":"BF01803788_CR31","first-page":"4161","volume":"53","author":"SB Fox","year":"1993","unstructured":"Fox SB, Gatter KC, Bicknell R, Going JJ, Stanton P, Cooke TG, Harris AL: Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res 53:4161\u20134163, 1993","journal-title":"Cancer Res"},{"key":"BF01803788_CR32","first-page":"331","volume":"18A","author":"SB Fox","year":"1994","unstructured":"Fox SB, Turner G, Gatter KC, Harris AL: The increased expression of the adhesion molecules PECAM, ICAM-1, ICAM-2, ICAM-3, E-selectin and P-selectin in breast cancer endothelium. J Cell Biochem S18A: 331\u2013331, 1994","journal-title":"J Cell Biochem S"},{"key":"BF01803788_CR33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/338557a0","volume":"338","author":"F Ishikawa","year":"1989","unstructured":"Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W, Heldin CH: Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338:557\u2013562, 1989","journal-title":"Nature"},{"key":"BF01803788_CR34","doi-asserted-by":"crossref","first-page":"12141","DOI":"10.1021\/bi00163a024","volume":"31","author":"A Moghaddam","year":"1992","unstructured":"Moghaddam A, Bicknell R: Expression of platelet derived endothelial cell growth factor inE.coli and confirmation of its thymidine phosphorylase activity. Biochemistry 31:12141\u201312146, 1992","journal-title":"Biochemistry"},{"key":"BF01803788_CR35","doi-asserted-by":"crossref","unstructured":"Moghaddam A, Zhang H-T, Fan T-PD, Hu D-E, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R: Thymidine phosphorylase is angiogenic and promotes tumour growth. Proc Natl Acad Sci USA (in press), 1995","DOI":"10.1073\/pnas.92.4.998"},{"key":"BF01803788_CR36","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1093\/jnci\/86.16.1234","volume":"86","author":"K Reynolds","year":"1994","unstructured":"Reynolds K, Farzaneh F, Collins WP, Campbell S, Bourne TH, Lawton F, Moghaddam A, Harris AL, Bicknell R: Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor. J Natl Cancer Inst 86:1234\u20131238, 1994","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR37","unstructured":"Zhang H-T, Craft P, Scott PAE, Ziche M, Weich HA, Harris AL, Bicknell R: Expression of vascular endothelial growth factor in MCF-7 cells enhances tumour growth and vascular density. JNCI, in press"},{"key":"BF01803788_CR38","first-page":"2168","volume":"53","author":"SW McLeskey","year":"1993","unstructured":"McLeskey SW, Kurebayashi J, Honig SF, Zwiebel J, Lippman ME, Dickson RB, Kern FG: Fibroblast growth factor-IV transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice. Cancer Res 53:2168\u20132177, 1993","journal-title":"Cancer Res"},{"key":"BF01803788_CR39","first-page":"2178","volume":"53","author":"J Kurebayashi","year":"1993","unstructured":"Kurebayashi J, McLeskey SW, Johnson MD, Lippman ME, Dickson RB, Kern FG: Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells co-transfected with fibroblast growth factor IV and lacZ. Cancer Res 53:2178\u20132187, 1993","journal-title":"Cancer Res"},{"key":"BF01803788_CR40","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/bjc.1994.172","volume":"69","author":"PS Braddock","year":"1994","unstructured":"Braddock PS, Hu D-E, Fan TP, Stratford IJ, Harris AL, Bicknell R: A structure activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions. Br J Cancer 69:890\u2013898, 1994","journal-title":"Br J Cancer"},{"key":"BF01803788_CR41","unstructured":"Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL: Platelet-derived endothelial cell growth factor \/ thymidine phosphorylase expression in normal tissues: an immunohisto-chemical study. In press."},{"key":"BF01803788_CR42","unstructured":"Patterson AV, Zhang H-T, Moghaddam A, Bicknell R, Talbot DC, Stratford IJ, Harris AL: Increased sensitivity to the prodrug 5\u2032-deoxy-5-fluorouridine and modulation of 5-fluoro-2\u2032-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase. In press."},{"key":"BF01803788_CR43","first-page":"7789","volume":"50","author":"JFJ Bligh","year":"1990","unstructured":"Bligh JFJ, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR: Activation of mitomycin C by NADPH:cytochrome P450 reductase. Cancer Res 50:7789\u20137792, 1990","journal-title":"Cancer Res"},{"key":"BF01803788_CR44","first-page":"4692","volume":"50","author":"PR Hoban","year":"1990","unstructured":"Hoban PR, Walton M, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID: Mitomycin C resistance under aerobic but not hypoxic conditions in a mammalian cell line: association with impaired drug activation and reduced NADPH cytochrome P450 reductase activity. Cancer Res 50:4692\u20134697, 1990","journal-title":"Cancer Res"},{"key":"BF01803788_CR45","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/0006-2952(93)90203-9","volume":"45","author":"JM Silva","year":"1993","unstructured":"Silva JM, Khan S, O'Brien PJ: Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes. Biochem Pharmacol 45:2303\u20132309, 1993","journal-title":"Biochem Pharmacol"},{"key":"BF01803788_CR46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0360-3016(94)90275-5","volume":"29","author":"PA Philip","year":"1994","unstructured":"Philip PA, Kaklamanis L, Ryley N, Stratford I, Wolf R, Harris AL, Carmichael J: Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumours in man. Int J Radiat Oncol Biol Phys 29:277\u2013283, 1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BF01803788_CR47","first-page":"2087","volume":"53","author":"B Davies","year":"1993","unstructured":"Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR: A synthetic matrix metalloproteinase inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 53:2087\u20132091, 1993","journal-title":"Cancer Res"},{"key":"BF01803788_CR48","first-page":"5649","volume":"53","author":"PA Philip","year":"1993","unstructured":"Philip PA, Thompson CH, Carmichael J, Rea D, Mitchell K, Taylor DJ, Stuart NSA, Dennis I, Rajagopolan B, Ganesan TS, Radda GK, Harris AL: A phase I study of the left-shifting agent BW12C79 plus mitomycin C and the effect on the skeletal muscle metabolism using31P magnetic resonance spectroscopy. Cancer Res 53:5649\u20135653, 1993","journal-title":"Cancer Res"},{"key":"BF01803788_CR49","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/jnci\/85.15.1206","volume":"85","author":"G Gasparini","year":"1993","unstructured":"Gasparini G, Pozza F, Harris AL: Evaluating the potential usefulness of new prognostic and predictive indicators in node-negative breast cancer patients. J Natl Cancer Inst 85:1206\u20131219, 1993","journal-title":"J Natl Cancer Inst"},{"key":"BF01803788_CR50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00666186","volume":"29","author":"S Fox","year":"1994","unstructured":"Fox S, Leek R, Smith K, Hollyer J, Greenall M, Harris A: Tumor angiogenesis in node negative breast carcinomas \u2014 relationship to epidermal growth factor receptor and survival. Breast Cancer Res Treat 29: 109\u2013116, 1994","journal-title":"Breast Cancer Res Treat"},{"key":"BF01803788_CR51","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/bjc.1993.211","volume":"67","author":"R Kalra","year":"1993","unstructured":"Kalra R, Wade KE, Hands L, Styles P, Camplejohn R, Greenall M, Adams GE, Harris AL, Radda GK: Phosphomonoester is associated with proliferation in human breast cancer: a31P MRS study. Br J Cancer 67:1145\u20131153, 1993","journal-title":"Br J Cancer"},{"key":"BF01803788_CR52","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/1097-0142(19940801)74:3+<1021::AID-CNCR2820741508>3.0.CO;2-1","volume":"74","author":"AL Harris","year":"1994","unstructured":"Harris AL, Fox S, Bicknell R, Leek R, Relf M, LeJeune S, Kaklamanis L: Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer. Cancer (Suppl) 74:1021\u20131025, 1994","journal-title":"Cancer (Suppl)"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01803788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01803788\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01803788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T13:46:01Z","timestamp":1557495961000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01803788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["BF01803788"],"URL":"https:\/\/doi.org\/10.1007\/bf01803788","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}