{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:19Z","timestamp":1760146639210},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1989,12,12]],"date-time":"1989-12-12T00:00:00Z","timestamp":629424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A congestive cardiomyopathy was diagnosed in a girl at the age of 4 weeks. In the weeks following she developed general muscle hypotonia and plasma lactate increased to 8.5 mmol\/L. Biochemical investigations of a muscle biopsy at the age of 3 months showed a deficiency in the oxidation of all substrates tested: pyruvate plus malate, 2\u2010ketoglutarate and palmitate plus malate. After freezing and thawing of the homogenate and the addition of essential cofactors, the oxidation of the ketoacids normalized. The oxidation defect in the untreated homogenate can be explained by a deficiency in one of the cofactors (such as thiamine pyrophosphate, NAD<jats:sup>+<\/jats:sup>or CoASH), or by a defect in the oxidative phosphorylation. Treatment with thiamine and carnitine resulted in a decrease in blood lactate to normal levels and a dramatic clinical improvement. Suspension of thiamine caused deterioration of her clinical condition and lactic acidaemia. The thiamine therapy was then continued. The girl is now 6 years old and in perfect health.<\/jats:p>","DOI":"10.1007\/bf01804393","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:58:36Z","timestamp":1119916716000},"page":"75-79","source":"Crossref","is-referenced-by-count":8,"title":["Neonatal cardiomyopathy and lactic acidosis responsive to thiamine"],"prefix":"10.1002","volume":"14","author":[{"given":"H. D.","family":"Bakker","sequence":"first","affiliation":[{"name":"Emma Kinderziekenhuis, Division of Paediatrics Academic Medical Centre Meibergdreef 9 Amsterdam 1105 AZ The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Scholte","sequence":"additional","affiliation":[{"name":"Department of Biochemistry I Erasmus University Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. E. M.","family":"Luyt\u2010Houwen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry I Erasmus University Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"van Gennip","sequence":"additional","affiliation":[{"name":"Emma Kinderziekenhuis, Division of Paediatrics Academic Medical Centre Meibergdreef 9 Amsterdam 1105 AZ The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G. G. M.","family":"Abeling","sequence":"additional","affiliation":[{"name":"Emma Kinderziekenhuis, Division of Paediatrics Academic Medical Centre Meibergdreef 9 Amsterdam 1105 AZ The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lam","sequence":"additional","affiliation":[{"name":"Emma Kinderziekenhuis, Division of Paediatrics Academic Medical Centre Meibergdreef 9 Amsterdam 1105 AZ The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,12,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(87)90211-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90209-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(78)90037-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90143-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02429041"},{"key":"e_1_2_1_7_1","first-page":"569","article-title":"Myocardiopathies primitives d'apparence idiopathique, chez l'enfant. Place des \u00e9tiologies m\u00e9taboliques","volume":"44","author":"Lombes A.","year":"1987","journal-title":"Arch. Fr. Pediatr."},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Erkrankungen des Herzens durch Stoffwechseldefekte","volume":"101","author":"Przyrembel H.","year":"1989","journal-title":"Wiener Klin. Wschr."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052534"},{"key":"e_1_2_1_10_1","first-page":"21","volume-title":"Carnitine in der Medizin","author":"Scholte H. R.","year":"1985"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01812849"},{"issue":"1","key":"e_1_2_1_12_1","first-page":"63","article-title":"The role of the carnitine system in myocardial fatty acid oxidation: carnitine deficiency, failing mitochondria and cardiomyopathy","volume":"82","author":"Scholte H. R.","year":"1987","journal-title":"Basic Res. Cardiol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0065-3101(24)00198-1","article-title":"Congestive cardiomyopathy of childhood","volume":"31","author":"Tripp M. E.","year":"1984","journal-title":"Adv. Pediatr."}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01804393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:53:56Z","timestamp":1706342036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01804393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12,12]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1007\/BF01804393"],"URL":"https:\/\/doi.org\/10.1007\/bf01804393","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12,12]]}}}