{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:15:48Z","timestamp":1760188548579},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1978,9,6]],"date-time":"1978-09-06T00:00:00Z","timestamp":273888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A male boy is described, who suffered from an intractable diarrhoea and several infections and who died in a severe marasmic state at the age of 8 months. Immunological studies revealed a block in the normal differentiation of B cells to Ig\u2010producing plasma cells. After the age of 5 months, however, this block disappeared, leading to a dramatic increase in circulating Ig, most pronounced in the IgM class. In the intestine, plasma cells could only be detected after the age of 5 months, and then with a marked preponderance of IgM cells.<\/jats:p><jats:p>Our results thus indicate a reversible block in the normal maturation of B cells in our patient. An older brother may have had a similar disease, suggesting a possible genetic basis for the disorder.<\/jats:p>","DOI":"10.1007\/bf01805582","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T00:02:21Z","timestamp":1119916941000},"page":"137-144","source":"Crossref","is-referenced-by-count":4,"title":["Transient B cell immaturity with intractable diarrhoea: A possible new immunodeficiency syndrome"],"prefix":"10.1002","volume":"1","author":[{"given":"S. O.","family":"Lie","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Institute of Immunology and Rheumatology, Institute of Pathology University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fr\u00f8land","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Institute of Immunology and Rheumatology, Institute of Pathology University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Brandtzaeg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Institute of Immunology and Rheumatology, Institute of Pathology University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Vandvik","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Institute of Immunology and Rheumatology, Institute of Pathology University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Steen\u2010Johnsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Porsgrunn Lutherske Sykehus  Porsgrunn Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,9,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80087-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(72)80172-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197305000-00004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.106.2.318"},{"key":"e_1_2_1_6_1","first-page":"1101","article-title":"Mucosal and glandular distribution of immunoglobulin components. 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