{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:46:24Z","timestamp":1791103584526,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1978,12,1]],"date-time":"1978-12-01T00:00:00Z","timestamp":281318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The classical features of Type I glycogen storage disease (McKusick 23220) (GSD) are hepatomegaly, hypoglycaemia, and acidosis, enlargement of the kidneys and short stature. Glucose\u20106\u2010phosphatase (EC 3.1.3.9) activity is defective not only in liver and kidney but also in small intestine (Field<jats:italic>et al.<\/jats:italic>, 1965). In addition to the classical features, many patients suffer from episodes of diarrhoea (Fine<jats:italic>et al.<\/jats:italic>, 1969).<\/jats:p><jats:p>At the Hospital for Sick Children, Great Ormond Street, patients with the commoner forms of hepatic glycogen storage disease have episodes of diarrhoea or loose stools more commonly than was suspected. We have investigated small intestinal function in three patients with Type I GSD by both<jats:italic>in vitro<\/jats:italic> and<jats:italic>in vivo<\/jats:italic> techniques.<\/jats:p>","DOI":"10.1007\/bf01805585","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T00:02:21Z","timestamp":1119916941000},"page":"155-157","source":"Crossref","is-referenced-by-count":24,"title":["Disordered intestinal function in glycogen storage disease"],"prefix":"10.1002","volume":"1","author":[{"given":"P. J.","family":"Milla","sequence":"first","affiliation":[{"name":"Department of Child Health Institute of Child Health  30 Guilford Street London WC1N 1EH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Atherton","sequence":"additional","affiliation":[{"name":"Department of Child Health Institute of Child Health  30 Guilford Street London WC1N 1EH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. V.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Child Health Institute of Child Health  30 Guilford Street London WC1N 1EH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. H.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Child Health Institute of Child Health  30 Guilford Street London WC1N 1EH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. D.","family":"Lake","sequence":"additional","affiliation":[{"name":"Department of Histopathology Hospital for Sick Children  Great Ormond Street London WC1N 3JH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1978,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1323","volume-title":"Handbook of Physiology. Alimentary canal, section 6, vol. III. Intestinal absorption","author":"Crane R. K.","year":"1968"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(60)91482-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720363.ch17"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Fairclough P. D. Clark M. L. Dawson A. M. Silk D. B. A. Milla P. J.andHarries J. T.(1978).Studies of glucose and maltose absorption in congenital glucose\u2010galactose malabsorption. Evidence against \u2018disaccharidase related\u2019 and diffusional transport of glucose in man.Pediatr. Res.In press.","DOI":"10.1203\/00006450-197812000-00002"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105230"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(69)80459-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1542\/peds.29.4.553","article-title":"Glucose\u20106\u2010phosphatase deficiency glycogen storage disease. Studies on the inter\u2010relationships of carbohydrate, lipid and purine abnormalities","volume":"29","author":"Howell R. R.","year":"1962","journal-title":"Pediatrics"},{"key":"e_1_2_1_9_1","first-page":"139","article-title":"A turbidometric method for the determination of higher polyethylene glycols in biological materials","volume":"22","author":"Hyden S.","year":"1955","journal-title":"K. Lanthr. Hogsk. Annr."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01004725"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66564-6_20"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196810312791803"},{"key":"e_1_2_1_13_1","first-page":"119","article-title":"Interrelationships between the absorption of glucose sodium and water by the normal human jejunum","volume":"36","author":"Sladen G. E.","year":"1968","journal-title":"Clin. Sci."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50870-5"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00546391"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1973.12096737"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01805585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01805585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T19:49:52Z","timestamp":1694893792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01805585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,12]]}},"alternative-id":["10.1007\/BF01805585"],"URL":"https:\/\/doi.org\/10.1007\/bf01805585","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,12]]}}}