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In order to investigate this problem, we have studied neutrophil functions (random locomotion and chemotaxis, O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> release, [1\u2010<jats:sup>14<\/jats:sup>C]glucose oxidation and cellular cytotoxicity) in two further patients with glycogenosis Ib and neutropenia. The results show that neutrophil dysfunctions related to the involvement of both hexose monophosphate shunt and anaerobic glycolysis were variable. The heterogeneity of neutrophil functional impairment in glycogenosis Ib and their possible relationship with the basic metabolic defect of the disease are discussed.<\/jats:p>","DOI":"10.1007\/bf01805597","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:19:03Z","timestamp":1119914343000},"page":"151-154","source":"Crossref","is-referenced-by-count":18,"title":["Neutropenia and impaired neutrophil function in glycogenosis type Ib"],"prefix":"10.1002","volume":"7","author":[{"given":"M.","family":"Di Rocco","sequence":"first","affiliation":[{"name":"Istituto G. Gaslini  Via 5 Maggio n. 39 Genova 16147 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Borrone","sequence":"additional","affiliation":[{"name":"Istituto G. Gaslini  Via 5 Maggio n. 39 Genova 16147 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Dallegri","sequence":"additional","affiliation":[{"name":"Clinica Medica R\u2010ISMI Universit\u00e0 degli Studi  Viale Benedetto XV, n. 6 Genova 16132 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Frumento","sequence":"additional","affiliation":[{"name":"Clinica Medica R\u2010ISMI Universit\u00e0 degli Studi  Viale Benedetto XV, n. 6 Genova 16132 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Patrone","sequence":"additional","affiliation":[{"name":"Clinica Medica R\u2010ISMI Universit\u00e0 degli Studi  Viale Benedetto XV, n. 6 Genova 16132 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,4,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107236"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441175"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80418-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80266-7"},{"key":"e_1_2_1_6_1","first-page":"859","article-title":"Role of the oxidative metabolic burst in the antibody\u2010dependent cellular cytotoxicity mediated by neutrophil polymorphonuclears","volume":"10","author":"Dallegri F.","year":"1982","journal-title":"Exp. 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