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Plasma, zinc and copper levels were compared with unselected hospital attenders. PKU patients were found to have significantly lower hair zinc (<jats:italic>P<\/jats:italic>&lt;0.001) and calcium (<jats:italic>P<\/jats:italic>&lt;0.01) concentrations and significantly higher hair copper (<jats:italic>P<\/jats:italic>&lt;0.001) concentrations compared with controls. Plasma zinc levels were below the lower limit of normal (9.6\u00b5mol l<jats:sup>\u22121<\/jats:sup>) in 8 of 19 patients (42%) in whom it was measured. The relative zinc deficiency in PKU patients may result from a competitive inhibition of absorption by copper or other metals supplemented in the diet.<\/jats:p>","DOI":"10.1007\/bf01805600","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:19:03Z","timestamp":1119914343000},"page":"160-164","source":"Crossref","is-referenced-by-count":19,"title":["The effect of treatment on zinc, copper and calcium status in children with phenylketonuria"],"prefix":"10.1002","volume":"7","author":[{"given":"C. J.","family":"Taylor","sequence":"first","affiliation":[{"name":"Alder Hey Children's Hospital and Department of Tropical Paediatrics Liverpool School of Tropical Medicine  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Moore","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Alder Hey Children's Hospital  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01800002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.12.909"},{"key":"e_1_2_1_4_1","first-page":"169","article-title":"Mineral and trace\u2010metal balances in children receiving normal and synthetic diets","volume":"43","author":"Alexander F. W.","year":"1974","journal-title":"Q. J. Med."},{"key":"e_1_2_1_5_1","first-page":"827","article-title":"Effect of diet on iron absorption in iron deficient rats","volume":"101","author":"Amire E. K.","year":"1971","journal-title":"J. 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