{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:35:52Z","timestamp":1782930952849,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,1,19]],"date-time":"1983-01-19T00:00:00Z","timestamp":411782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A variety of phagocytic cell and lymphocyte assays were employed to evaluate the immune status of four patients with methylmalonicaciduria. One patient had a depressed absolute granulocyte count and two patients had depressed neutrophil and monocyte chemotactic responses. All subjects had normal neutrophil phagocytic and bactericidal activities. One patient had a decreased T\u2010cell number; blastogenic responses to phytohaemagglutinin and pokeweed mitogen were normal in all subjects. B lymphocyte measurements were variably abnormal; two children had decreased B\u2010cell numbers; two had marginally decreased IgG levels; a third had an undetectable rubella titre; and two had elevated serum IgE concentrations.<jats:italic>In vitro<\/jats:italic> exposure of normal cells to methylmalonic acid concentrations up to 50mg\/100 ml did not affect chemotactic or lymphoproliferative responses.<\/jats:p><jats:p>In conclusion, although B\u2010cell function may be affected, no consistent abnormality of lymphocyte or phagocytic cell functions could be attributed to the metabolic disorder.<\/jats:p>","DOI":"10.1007\/bf01805612","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:53:45Z","timestamp":1119916425000},"page":"12-14","source":"Crossref","is-referenced-by-count":25,"title":["Immune functions in methylmalonicaciduria"],"prefix":"10.1002","volume":"7","author":[{"given":"J. A.","family":"Church","sequence":"first","affiliation":[{"name":"Department of Pediatrics Childrens Hospital of Los Angeles and the University of Southern California School of Medicine  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Childrens Hospital of Los Angeles and the University of Southern California School of Medicine  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. N. F.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Childrens Hospital of Los Angeles and the University of Southern California School of Medicine  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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