{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:47:21Z","timestamp":1770500841795,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1989,10,1]],"date-time":"1989-10-01T00:00:00Z","timestamp":623203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Tr"],"published-print":{"date-parts":[[1989,10]]},"DOI":"10.1007\/bf01805978","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T00:17:29Z","timestamp":1119917849000},"page":"77-90","source":"Crossref","is-referenced-by-count":59,"title":["Prognostic value of epidermal growth factor receptor in node-positive breast cancer"],"prefix":"10.1007","volume":"14","author":[{"given":"M.","family":"Grimaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Romain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Remvikos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Magdel\u00e9nat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01805978_CR1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1146\/annurev.bi.48.070179.001205","volume":"48","author":"G Carpenter","year":"1979","unstructured":"Carpenter G, Cohen S: Epidermal growth factor. Ann Rev Biochem 48: 198\u2013216, 1979","journal-title":"Ann Rev Biochem"},{"key":"BF01805978_CR2","first-page":"3442","volume":"44","author":"SL Fitzpatrick","year":"1984","unstructured":"Fitzpatrick SL, Lachance MP, Schultz GS: Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture. Cancer Res 44: 3442\u20133447, 1984","journal-title":"Cancer Res"},{"key":"BF01805978_CR3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0092-8674(84)90365-9","volume":"37","author":"G Carpenter","year":"1984","unstructured":"Carpenter G: Properties of the receptor for epidermal growth factor. Cell 37: 357\u2013358, 1984","journal-title":"Cell"},{"key":"BF01805978_CR4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.bi.56.070187.004313","volume":"56","author":"G Carpenter","year":"1987","unstructured":"Carpenter G: Receptors for epidermal growth factor and other polypetide mitogens. Ann Rev Biochem 56: 881\u2013914, 1987","journal-title":"Ann Rev Biochem"},{"key":"BF01805978_CR5","first-page":"2621","volume":"42","author":"AB Roberts","year":"1983","unstructured":"Roberts AB, Frolick CA, Anzano MA, Sporn MB: Transforming growth factors from neoplastic and non-neoplastic tissues. Fed Proc 42: 2621\u20132625, 1983","journal-title":"Fed Proc"},{"key":"BF01805978_CR6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/313745a0","volume":"313","author":"MB Sporn","year":"1985","unstructured":"Sporn MB, Roberts AB: Autocrine growth factors and cancer. Nature 313: 747\u2013751, 1985","journal-title":"Nature"},{"key":"BF01805978_CR7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF01806790","volume":"7","author":"ME Lippman","year":"1986","unstructured":"Lippman ME, Dickson RB, Bates S, Knabbe C, Huff K, Swain S, McManaway M, Bronzert D, Kassid A, Gelmann EP: Autocrine and paracrine growth regulation of human breast cancer. Breast Cancer Res Treat 7: 59\u201370, 1986","journal-title":"Breast Cancer Res Treat"},{"key":"BF01805978_CR8","unstructured":"Ozanne B, Shum A, Richards CS, Cassells D, Grossman D, Trent J, Gusterson B, Hendler F: Evidence for an increase of EGF receptors in epidermoid malignancies. In Cancer Cells: Growth Factors and Transformation Cold Spring Harbor Laboratory. pp 41\u201348, 1985"},{"key":"BF01805978_CR9","first-page":"3448","volume":"44","author":"SL Fitzpatrick","year":"1984","unstructured":"Fitzpatrick SL, Brightwell J, Wittliff JL, Barrows GH, Schultz GS: Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels. Cancer Res 44: 3448\u20133453, 1984","journal-title":"Cancer Res"},{"key":"BF01805978_CR10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF01806484","volume":"4","author":"R Perez","year":"1984","unstructured":"Perez R, Pasqual M, Macias A, Loge A: Epidermal growth factor receptors in human breast cancer. Breast Cancer Res Treat 4: 189\u2013193, 1984","journal-title":"Breast Cancer Res Treat"},{"key":"BF01805978_CR11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(85)91385-6","volume":"1","author":"JRC Sainsbury","year":"1985","unstructured":"Sainsbury JRC, Farndon JR, Sherbet GV, Harris AL: Epidermal growth factor receptors and oestrogen receptors in human breast cancer. Lancet 1: 364\u2013366, 1985","journal-title":"Lancet"},{"key":"BF01805978_CR12","first-page":"687","volume":"74","author":"M Grimaux","year":"1987","unstructured":"Grimaux M, Remvikos Y, Magdelenat H: R\u00e9cepteurs d'EGF et r\u00e9cepteurs hormonaux dans les tumeurs mammaires (Abstract). Bull Cancer 74: 687, 1987","journal-title":"Bull Cancer"},{"key":"BF01805978_CR13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000217563","volume":"9","author":"V Cappelletti","year":"1988","unstructured":"Cappelletti V, Brivio M, Miodini P, Granata G, Coradini D, Di Fronzo G: Simultaneous estimation of epidermal growth factor receptors and steroid receptors in a series of 136 resectable primary breast tumors. Tumor Biol 9: 200\u2013211, 1988","journal-title":"Tumor Biol"},{"key":"BF01805978_CR14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF01805841","volume":"11","author":"JC Delarue","year":"1988","unstructured":"Delarue JC, Friedman S, Mouriesse H, May-Levin F, Sancho-Garnier H, Contesso G: Epidermal growth factor receptor in human breast cancers: correlation with estrogen and progesterone receptors. Breast Cancer Res Treat 11: 173\u2013178, 1988","journal-title":"Breast Cancer Res Treat"},{"key":"BF01805978_CR15","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/jcp.38.11.1225","volume":"38","author":"JRC Sainsbury","year":"1985","unstructured":"Sainsbury JRC, Malcolm AJ, Appleton DR, Farndon JR, Harris AL: Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. J Clin Pathol 38: 1225\u20131228, 1985","journal-title":"J Clin Pathol"},{"key":"BF01805978_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/bjc.1986.173","volume":"54","author":"L Skoog","year":"1986","unstructured":"Skoog L, Macias A, Azavedo E, Lombardero J, Klintenberg C: Receptors for EGF and oestradiol and thymidine kinase activity in different histological subgroups of human mammary carcinomas. Br J Cancer 54: 271\u2013276, 1986","journal-title":"Br J Cancer"},{"key":"BF01805978_CR17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.1711500107","volume":"150","author":"RA Walker","year":"1986","unstructured":"Walker RA, Camplejohn RS: DNA flow cytometry of human breast carcinomas and its relationship to transferrin and epidermal growth factor receptors. J Pathol 150: 37\u201342, 1986","journal-title":"J Pathol"},{"key":"BF01805978_CR18","first-page":"459","volume":"7","author":"A Macias","year":"1987","unstructured":"Macias A, Azavedo E, H\u00e4gerstrom T, Klintenberg C, Perez R, Skoog L: Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas. Anticancer Res 7: 459\u2013464, 1987","journal-title":"Anticancer Res"},{"key":"BF01805978_CR19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ijc.2910390302","volume":"39","author":"E Spitzer","year":"1987","unstructured":"Spitzer E, Grosse R, Kunde D, Schmidt HE: Growth of mammary epithelial cells in breast-cancer biopsies correlates with EGF binding. Int J Cancer 39: 279\u2013282, 1987","journal-title":"Int J Cancer"},{"key":"BF01805978_CR20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ijc.2910410204","volume":"41","author":"G Cattoretti","year":"1988","unstructured":"Cattoretti G, Rilke F, Andreola S, D'Amato L, Delia D: P53 expression in breast cancer. Int J Cancer 41: 178\u2013183, 1988","journal-title":"Int J Cancer"},{"key":"BF01805978_CR21","first-page":"1398","volume":"1","author":"JCR Sainsbury","year":"1987","unstructured":"Sainsbury JCR, Farndon JR, Needham GK, Malcolm AJ, Harris AL: Epidermal growth factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet 1: 1398\u20131402, 1987","journal-title":"Lancet"},{"key":"BF01805978_CR22","first-page":"173","volume":"8","author":"MA Rios","year":"1988","unstructured":"Rios MA, Macias A, P\u00e9rez R, Lage A, Skoog L: Receptors for epidermal growth factor and estrogen as predictors of relapse in patients with mammary carcinoma. Anticancer Res 8: 173\u2013176, 1988","journal-title":"Anticancer Res"},{"key":"BF01805978_CR23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0277-5379(86)90061-1","volume":"22","author":"A Koenders","year":"1986","unstructured":"Koenders A, Thorpe SM: Standardisation of steroid receptor assay in human breast III. Selection of reference material for intra and inter laboratory quality control. Eur J Cancer Clin Oncol 22: 939\u2013944, 1986","journal-title":"Eur J Cancer Clin Oncol"},{"key":"BF01805978_CR24","first-page":"96","volume":"144","author":"M Grimaux","year":"1988","unstructured":"Grimaux M, Magdelenat H, Poisson M, Chamouard JM, Barritault D, Foncin JF, Philippon J: R\u00e9cepteurs d'EGF (Epidermal growth factor) et de st\u00e9ro\u00efdes dans les m\u00e9ningiomes humains. Rev Neurol (Paris) 144: 96\u2013103, 1988","journal-title":"Rev Neurol (Paris)"},{"key":"BF01805978_CR25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0003-2697(81)90130-5","volume":"110","author":"B Fiszer-Szafarz","year":"1981","unstructured":"Fiszer-Szafarz B, Szafarz D, Guevava de Murillo A: A general fast and sensitive micromethod for DNA determination. Analyt Biochem, 110: 165\u2013170, 1981","journal-title":"Analyt Biochem"},{"key":"BF01805978_CR26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 72: 248\u2013254, 1976","journal-title":"Analyt Biochem"},{"key":"BF01805978_CR27","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1016\/S0021-9258(19)44568-7","volume":"247","author":"CR Savage","year":"1972","unstructured":"Savage CR, Cohen S: Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization. J Biol Chem 247: 7609\u20137611, 1972","journal-title":"J Biol Chem"},{"key":"BF01805978_CR28","first-page":"427","volume":"8","author":"SD Elson","year":"1984","unstructured":"Elson SD, Browne CA, Thorburn GD: Extraction and purification of murine epidermal growth factor. Biochem Internat 8: 427\u2013435, 1984","journal-title":"Biochem Internat"},{"key":"BF01805978_CR29","first-page":"2172","volume":"47","author":"AS Weisman","year":"1987","unstructured":"Weisman AS, Raguet SS, Kelly PA: Characterization of the epidermal growth factor receptor in human meningioma. Cancer Res 47: 2172\u20132176, 1987","journal-title":"Cancer Res"},{"key":"BF01805978_CR30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1073\/pnas.74.2.565","volume":"74","author":"RN Fabricant","year":"1977","unstructured":"Fabricant RN, DeLarco JE, Todaro GJ: NGF receptors on human melanoma cells in culture. Proc Natl Acad Sci USA 74: 565\u2013569, 1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01805978_CR31","volume-title":"Rank Correlation Methods","author":"MG Kendall","year":"1962","unstructured":"Kendall MG: Rank Correlation Methods (3rd ed). Hafner, New York, 1962","edition":"3rd ed"},{"key":"BF01805978_CR32","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/25.7.894009","volume":"25","author":"IT Young","year":"1977","unstructured":"Young IT: Proof without prejudice. Use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources. J Histochem Cytochem 25: 935\u2013941, 1977","journal-title":"J Histochem Cytochem"},{"key":"BF01805978_CR33","first-page":"163","volume":"50","author":"N Mantel","year":"1966","unstructured":"Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50: 163\u2013170, 1966","journal-title":"Cancer Chemother Rep"},{"key":"BF01805978_CR34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"DR Cox","year":"1972","unstructured":"Cox DR: Regression models and life tables. J R Stat Soc 34: 187\u2013202, 1972","journal-title":"J R Stat Soc"},{"key":"BF01805978_CR35","first-page":"101","volume-title":"Cancer du Sein. D\u00e9finition du risque m\u00e9tastatique","author":"M Namer","year":"1988","unstructured":"Namer M: Bilan de l'hormonoth\u00e9rapie adjuvante et des associations hormono-chimioth\u00e9rapiques adjuvantes. In Serin D ed. Cancer du Sein. D\u00e9finition du risque m\u00e9tastatique. Bilan des th\u00e9rapeutiques adjuvantes. Masson (Paris). pp 101\u2013125, 1988"},{"key":"BF01805978_CR36","first-page":"2314","volume":"48","author":"G Bonadonna","year":"1988","unstructured":"Bonadonna G, Valagussa P: The contribution of medicine to the primary treatment of breast cancer. Cancer Res 48: 2314\u20132324, 1988","journal-title":"Cancer Res"},{"issue":"2","key":"BF01805978_CR37","first-page":"20","volume":"15","author":"GM Clark","year":"1988","unstructured":"Clark GM, McGuire WL: Steroid receptors and other prog-nostic factors in primary breast cancer. Seminars in Oncology 15 (2, Suppl 1): 20\u201325, 1988","journal-title":"Seminars in Oncology"},{"key":"BF01805978_CR38","first-page":"1890","volume":"40","author":"JS Meyer","year":"1980","unstructured":"Meyer JS, Lee JY: Relationship of S phase fraction of breast carcinoma in relapse to duration of remission, estrogen receptor content, therapeutic responsiveness, and duration of survival. Cancer Res 40: 1890\u20131896, 1980","journal-title":"Cancer Res"},{"key":"BF01805978_CR39","unstructured":"Meyer JS: Cell kinetics and stratification of patients for adjuvant therapy of breast carcinoma. NCI Monographs 1: 25\u201328"},{"key":"BF01805978_CR40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/ijc.2910330404","volume":"33","author":"A Tubiana","year":"1984","unstructured":"Tubiana A, Pejovic MH, Chavaudra N, Contesso G, Malaise EP: The long term prognostic significance of the kinetics labelling index in breast cancer. Int J Cancer 33: 441\u2013445, 1984","journal-title":"Int J Cancer"},{"key":"BF01805978_CR41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ijc.2910420108","volume":"42","author":"S Nicholson","year":"1988","unstructured":"Nicholson S, Sainsbury JRC, Needham GK, Chambers P, Farndon JR, Harris AL: Quantitative assay of Epidermal Growth Factor Receptor in human breast cancer: Cut-off points of clinical relevance. Int J Cancer 42: 36\u201341, 1988","journal-title":"Int J Cancer"},{"key":"BF01805978_CR42","first-page":"849","volume":"6","author":"A Macias","year":"1986","unstructured":"Macias A, Azavedo A, Perez R, Rutqvist LE, Skoog L: Receptors for epidermal growth factor in mammary carcinomas and their metastases. Anticancer Res 6: 849\u2013852, 1986","journal-title":"Anticancer Res"},{"key":"BF01805978_CR43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cyto.990080216","volume":"8","author":"M Opferman","year":"1987","unstructured":"Opferman M, Brugal G, Vassilakos P: Cytometry of breast carcinoma: significance of plo\u00efdy balance and proliferation index. Cytometry 8: 217\u2013224, 1987","journal-title":"Cytometry"},{"key":"BF01805978_CR44","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/cyto.990090616","volume":"9","author":"Y Remvikos","year":"1988","unstructured":"Remvikos Y, Gerbault-Seurreau M, Vielh P, Zafrani B, Magdelenat H, Dutrillaux B: Relevance of DNA plo\u00efdy as a measure of genetic deviation: a comparison of flow cytometry and cytogenetic data in 25 cases of human breast cancer. Cytometry 9: 612\u2013618, 1988","journal-title":"Cytometry"},{"key":"BF01805978_CR45","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/1097-0142(19880201)61:3<420::AID-CNCR2820610303>3.0.CO;2-0","volume":"61","author":"LG Dressler","year":"1988","unstructured":"Dressler LG, Seamer LG, Owens MA, Clark GM, McGuire WL: DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens. Cancer 61: 420\u2013427, 1988","journal-title":"Cancer"},{"key":"BF01805978_CR46","first-page":"1343","volume":"48","author":"F Pekonen","year":"1988","unstructured":"Pekonen F, Partanen S, M\u00e4kinen T, Rutanen EM: Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer. Cancer Res 48: 1343\u20131347, 1988","journal-title":"Cancer Res"},{"key":"BF01805978_CR47","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1200\/JCO.1988.6.7.1076","volume":"6","author":"B Fisher","year":"1988","unstructured":"Fisher B, Redmond C, Fisher ER, Caplan R, and other NSABP Investigators: Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: findings from NSABP protocl B-06. J Clin Oncol 6: 1076\u20131087, 1988","journal-title":"J Clin Oncol"},{"key":"BF01805978_CR48","doi-asserted-by":"crossref","unstructured":"Carpenter G, Stoscheck CH, Preston YA, De Larco JE: Antibodies to the epidermal growth factor receptor block the biological effects of sarcoma growth factor. Proc Natl Acad Sci USA 80: 5627\u20135634","DOI":"10.1073\/pnas.80.18.5627"},{"key":"BF01805978_CR49","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0014-4827(86)90348-4","volume":"162","author":"Y Kuratomi","year":"1986","unstructured":"Kuratomi Y, Shin-Ishi A, Ono M, Shiraishi N, Shimada T, Ohkuma S, Kuwano M: Thioridazine enhances lysosomal accumulation of epidermal growth factor and toxicity of conjugates of epidermal growth factor with Pseudomonas endotoxin. Exp Cell Res 162: 436\u2013448, 1986","journal-title":"Exp Cell Res"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01805978.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01805978\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01805978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:02:35Z","timestamp":1735776155000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01805978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["BF01805978"],"URL":"https:\/\/doi.org\/10.1007\/bf01805978","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}