{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:55:23Z","timestamp":1781603723363,"version":"3.54.5"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Tr"],"published-print":{"date-parts":[[1996,2]]},"DOI":"10.1007\/bf01807031","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:32:05Z","timestamp":1119915125000},"page":"1-13","source":"Crossref","is-referenced-by-count":35,"title":["Immunocytochemical detection of breast cancer cells in marrow and peripheral blood of patients undergoing high dose chemotherapy with autologous stem cell support"],"prefix":"10.1007","volume":"41","author":[{"given":"Wilbur A.","family":"Franklin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Shpall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Garza-Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Bast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy B.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01807031_CR1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1200\/JCO.1988.6.9.1368","volume":"6","author":"WP Peters","year":"1988","unstructured":"Peters WP, Shpall EJ, Jones RB et al.: High-dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer. J Clin Oncol 6: 1368\u20131375, 1988","journal-title":"J Clin Oncol"},{"key":"BF01807031_CR2","first-page":"22","volume":"9","author":"WP Peters","year":"1990","unstructured":"Peters WP, Davis R, Shpall EJ et al.: Adjuvant chemotherapy involving high-dose combination cyclophosphamide, cisplatin, carmustine (CPA\/CDDP\/BCNU with bone marrow support for stage II\/II breast cancer involving ten or more lymph nodes (CALGB 8782): A preliminary report. Proc Am Soc Clin Oncol 9: 22, 1990 (abstr)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF01807031_CR3","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/jnci\/83.13.920","volume":"83","author":"MJ Kennedy","year":"1991","unstructured":"Kennedy MJ, Beveridge RA, Rowley SD, Gordon GB, Abeloff MD, Davidson NE: High-dose chemotherapy with reinfusion of purged autologous bone marrow following dose-intense induction as initial therapy for metastatic breast cancer. J Natl Cancer Inst 83: 920\u2013926, 1991","journal-title":"J Natl Cancer Inst"},{"key":"BF01807031_CR4","first-page":"255","volume":"21","author":"MD Vincent","year":"1988","unstructured":"Vincent MD, Powles TJ, Coombes RC, McElwain TJ: Late intensification with high-dose melphalan and autologous bone marrow support in breast cancer patients responding to conventional chemotherapy. Cancer Chemother Pharmacol 21: 255\u2013260, 1988","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF01807031_CR5","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1200\/JCO.1990.8.7.1207","volume":"8","author":"FR Dunphy","year":"1990","unstructured":"Dunphy FR, Spitzer G, Buzdar AU et al.: Treatment of estrogen receptor-negative or hormonally refractory breast cancer with double high-dose chemotherapy intensification and bone marrow support. J Clin Oncol 8: 1207\u20131216, 1990","journal-title":"J Clin Oncol"},{"key":"BF01807031_CR6","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1200\/JCO.1989.7.12.1824","volume":"7","author":"SF Williams","year":"1989","unstructured":"Williams SF, Mick R, Desser R, Golick J, Beschorner J, Bitran JD: High-dose consolidation therapy with autologous stem cell rescue in stage IV breast cancer. J Clin Oncol 7: 1824\u20131830, 1989","journal-title":"J Clin Oncol"},{"issue":"Suppl 5","key":"BF01807031_CR7","first-page":"11","volume":"18","author":"GN Hortobagyi","year":"1991","unstructured":"Hortobagyi GN: Bone metastases in breast cancer patients. Sem Oncol 18 (Suppl 5): 11\u201315, 1991","journal-title":"Sem Oncol"},{"issue":"Suppl 1","key":"BF01807031_CR8","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/8756-3282(91)90059-R","volume":"12","author":"M Tubiana-Hulin","year":"1991","unstructured":"Tubiana-Hulin M: Incidence, prevalence and distribution of bone metastases. Bone 12 (Suppl 1): S9-S10, 1991","journal-title":"Bone"},{"key":"BF01807031_CR9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/stem.5530100731","volume":"10","author":"J Sharp","year":"1992","unstructured":"Sharp J, Kessinger A, Mann S: Detection and clinical significance of minimal tumor cell contamination of peripheral blood stem cell harvest. Int J Cell Cloning 10: 92\u201394, 1992","journal-title":"Int J Cell Cloning"},{"key":"BF01807031_CR10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1182\/blood.V83.3.636.636","volume":"83","author":"W Brugger","year":"1994","unstructured":"Brugger W, Bross KJ, Glatt B, Georgi F, Mertelsmann R, Kanz L: Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 83: 636\u2013640, 1994","journal-title":"Blood"},{"key":"BF01807031_CR11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1200\/JCO.1991.9.1.85","volume":"9","author":"EJ Shpall","year":"1991","unstructured":"Shpall EJ, Jones RB, Bast RC et al.: 4-Hydroperoxycyclophosphamide purging of breast cancer from the mononuclear cell fraction of bone marrow in patients receiving high-dose chemotherapy and autologous marrow support: a phase I trial. J Clin Oncol 9: 85\u201393, 1991","journal-title":"J Clin Oncol"},{"key":"BF01807031_CR12","first-page":"58","volume":"11","author":"JJ Vredenburgh","year":"1992","unstructured":"Vredenburgh JJ, Shpall EJ, Ross M et al.: Immunopharmacologic bone marrow purging and high dose chemotherapy with autologous bone marow support (ABMS) for patients with metastatic breast cancer. Proc Am Soc Clin Oncol 11: 58, 1992 (abstr)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF01807031_CR13","first-page":"145","volume":"7","author":"EJ Shpall","year":"1991","unstructured":"Shpall EJ, Bast RC, Joines WT et al.: Immunomagnetic purging of breast cancer from bone marrow for autologous transplantation. Bone Marrow Transplant 7: 145\u2013151, 1991","journal-title":"Bone Marrow Transplant"},{"key":"BF01807031_CR14","unstructured":"Shpall EJ, Jones RB, Johnston C et al.: WR-2721 (Amifostine) shortens the engraftment period of 4-hydroperoxycyclophosphamide (4-HC) purged bone marrow patients receiving high-dose chemotherapy with autologous bone marrow support (ABMS). Blood 78 (Suppl 1): 192a, 1991 (abstr)"},{"key":"BF01807031_CR15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1200\/JCO.1994.12.1.28","volume":"12","author":"EJ Shpall","year":"1994","unstructured":"Shpall EJ, Jones RB, Franklin WA et al.: Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: Influence of CD34+ peripheral blood progenitors and growth factors on engraftment. J Clin Oncol 12: 28\u201336, 1994","journal-title":"J Clin Oncol"},{"key":"BF01807031_CR16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/ajcp\/94.1.8","volume":"94","author":"DS Leslie","year":"1990","unstructured":"Leslie DS, Johnston WW, Daly L et al.: Detection of breast carcinoma cells in human bone marrow using fluorescence-activated cell sorting and conventional cytology. Am J Clin Pathol 94: 8\u201313, 1990","journal-title":"Am J Clin Pathol"},{"key":"BF01807031_CR17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/1097-0142(19910215)67:4<1033::AID-CNCR2820670428>3.0.CO;2-H","volume":"67","author":"A Molino","year":"1991","unstructured":"Molino A, Colobatti M, Bonetti F et al.: A comparative analysis of three different techniques for the detection of breast cancer cells in bone marrow. Cancer 67: 1033\u20131036, 1991","journal-title":"Cancer"},{"key":"BF01807031_CR18","first-page":"179","volume":"6","author":"SS Joshi","year":"1990","unstructured":"Joshi SS, Novak DJ, Messbarger L, Maitreyan V, Weisenburger DD, Sharp JG: Levels of detection of tumor cells in human bone marrow with or without prior culture. Bone Marrow Transplant 6: 179\u2013183, 1990","journal-title":"Bone Marrow Transplant"},{"key":"BF01807031_CR19","first-page":"9","volume":"9","author":"WP Vaughn","year":"1990","unstructured":"Vaughn WP, Mann SL, Garvey J et al.: Breast cancer detected in cell culture of histologically negative bone marrow predicts systemic relapse in patients with stage I, II, III and locally recurrent disease. Proc Am Soc Clin Oncol 9: 9, 1990 (abstr)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF01807031_CR20","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJM199111283252201","volume":"325","author":"JC Gribben","year":"1991","unstructured":"Gribben JC, Freedmen AS, Neuberg D et al.: Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. New Engl J Med 325: 1525\u20131533, 1991","journal-title":"New Engl J Med"},{"key":"BF01807031_CR21","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/bjc.1993.171","volume":"67","author":"R Yuan","year":"1993","unstructured":"Yuan R, Dowling P, Zucca E et al.: Detection of bc1-2\/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis. Br J Cancer 67: 922\u2013925, 1993","journal-title":"Br J Cancer"},{"key":"BF01807031_CR22","first-page":"3079","volume":"40","author":"J Sloane","year":"1980","unstructured":"Sloane J, Ormerod MC, Neville AM: Potential pathological application of immunocytochemical methods to the detection of micrometastases. Cancer Res 40: 3079\u20133082, 1980","journal-title":"Cancer Res"},{"key":"BF01807031_CR23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/bjc.1981.152","volume":"44","author":"DP Dearnaley","year":"1981","unstructured":"Dearnaley DP, Sloane JP, Ormerod MG et al.: Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen. Br J Cancer 44: 85\u201390, 1981","journal-title":"Br J Cancer"},{"key":"BF01807031_CR24","doi-asserted-by":"crossref","first-page":"8672","DOI":"10.1073\/pnas.84.23.8672","volume":"84","author":"G Schlimok","year":"1987","unstructured":"Schlimok G, Funke I, Holzmann B et al.: Micrometastatic cancer cells in bone marrow:In vitro detection with anticytokeratin andin vivo labeling with anti-17-1A monoclonal antibodies. Proc Natl Acad Sci USA 84: 8672\u20138676, 1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF01807031_CR25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00000478-198805000-00001","volume":"12","author":"RJ Cote","year":"1988","unstructured":"Cote RJ, Rosen PP, Hakes TB et al.: Monoclonal antibodies detect occult breast carcinoma metastases in the bone marrow of patients with early stage disease. Am J Surg Pathol 12: 333\u2013340, 1988","journal-title":"Am J Surg Pathol"},{"key":"BF01807031_CR26","first-page":"2706","volume":"51","author":"MP Osborne","year":"1991","unstructured":"Osborne MP, Wong GY, Asina S, Old LJ, Cote RJ, Rosen PP: Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow. Cancer Res 51: 2706\u20132709, 1991","journal-title":"Cancer Res"},{"key":"BF01807031_CR27","first-page":"25","volume":"8","author":"MP Osborne","year":"1994","unstructured":"Osborne MP, Rosen PP: Detection and management of bone marrow micrometastases in breast cancer. Oncol 8: 25\u201331, 1994","journal-title":"Oncol"},{"key":"BF01807031_CR28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1136\/bmj.295.6606.1093","volume":"295","author":"JL Mansi","year":"1987","unstructured":"Mansi JL, Berger U, Easton D et al.: Micrometastases. Br Med J 295: 1093\u20131096, 1987","journal-title":"Br Med J"},{"key":"BF01807031_CR29","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1200\/JCO.1991.9.10.1749","volume":"9","author":"RJ Cote","year":"1991","unstructured":"Cote RJ, Rosen PP, Lesser ML, Old LJ, Osborne MP: Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol 9: 1749\u20131756, 1991","journal-title":"J Clin Oncol"},{"key":"BF01807031_CR30","first-page":"2266","volume":"54","author":"J Passos-Coelho","year":"1994","unstructured":"Passos-Coelho J, Ross AA, Davis JM, Huelskamp A-M, Clarke B, Noga SJ, Davidson NE, Kennedy MJ: Bone marrow micrometastasis in chemotherapy-responsive advanced breast cancer: Effect ofex vivo purging with 4-hydroxycyclophosphamide. Cancer Res 54: 2266\u20132371, 1994","journal-title":"Cancer Res"},{"issue":"77","key":"BF01807031_CR31","first-page":"69","volume":"12","author":"AA Ross","year":"1993","unstructured":"Ross AA, Cooper BW, Lazarus HM et al.: Incidence of tumor cell contamination in peripheral blood stem cell (PBSC) collections from breast cancer patients. Proc Am Soc Clin Oncol 12: 69 (77), 1993","journal-title":"Proc Am Soc Clin Oncol"},{"issue":"Suppl 1","key":"BF01807031_CR32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/stem.5530100731","volume":"10","author":"JC Sharp","year":"1992","unstructured":"Sharp JC, Kessinger A, Mann S: Detection and clinical significance of minimal tumor cell contamination of peripheral blood stem cell harvests. Intl J Cell Clon 10 (Suppl 1): 92\u201392, 1992","journal-title":"Intl J Cell Clon"},{"key":"BF01807031_CR33","first-page":"273","volume":"4","author":"AE Frankel","year":"1985","unstructured":"Frankel AE, Ring DB, Tringale F, Hsieh-Ma ST: Tissue distribution of breast cancer-associated antigens defined by monoclonal antibodies. J Biol Response Mod 4: 273\u2013286, 1985","journal-title":"J Biol Response Mod"},{"key":"BF01807031_CR34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ijc.2910430113","volume":"43","author":"CM Boyer","year":"1989","unstructured":"Boyer CM, Borowitz MJ, McCarty KS et al.: Heterogeneity of antigen expression in benign and malignant breast and ovarian epithelial cells. Int J Cancer 43: 55\u201360, 1989","journal-title":"Int J Cancer"},{"key":"BF01807031_CR35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1089\/hyb.1990.9.221","volume":"9","author":"JA Peterson","year":"1990","unstructured":"Peterson JA, Zava DT, Duwe AK, Blank EW, Battifora H, Ceriani RL: Biochemical and histological characterization of antigens preferentially expressed on the surface and cytoplasm of breast carcinoma cells identified by monoclonal antibodies against the human milk fat globule. Hybridoma 9: 221\u2013235, 1990","journal-title":"Hybridoma"},{"key":"BF01807031_CR36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ijc.2910570704","volume":"8","author":"RA Stahel","year":"1994","unstructured":"Stahel RA, Gilks WR, Lehmann H-P, Schenker T: Third International Workshop on Lung Tumor and Differentiation Antigens: Overview of the results of the central data analysis. Int J Cancer 8: 6\u201326, 1994","journal-title":"Int J Cancer"},{"key":"BF01807031_CR37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/jnci\/58.2.209","volume":"58","author":"J Fogh","year":"1977","unstructured":"Fogh J, Wright WC, Loveless JD: Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst 58: 209\u2013213, 1977","journal-title":"J Natl Cancer Inst"},{"key":"BF01807031_CR38","first-page":"676","volume":"52","author":"H Stein","year":"1985","unstructured":"Stein H, Gatter K, Asbahr H, Mason DY: Use of freezedried paraffin-embedded sections for immunohistologic staining with monoclonal antibodies. Lab Invest 52: 676\u2013683, 1985","journal-title":"Lab Invest"},{"key":"BF01807031_CR39","first-page":"200","volume-title":"Statistical Methods","author":"GW Snedecor","year":"1989","unstructured":"Snedecor GW, Cochran WG: Statistical Methods. Iowa State University Press, Ames, Iowa, USA, Eighth Edition, 1989, p 200","edition":"Eighth Edition"},{"key":"BF01807031_CR40","unstructured":"ibid: Regression, pp 177\u2013190"},{"key":"BF01807031_CR41","unstructured":"ibid: Fitting a straight line through the origin, pp 174\u2013176"},{"key":"BF01807031_CR42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/1097-0142(19900801)66:3<431::AID-CNCR2820660305>3.0.CO;2-X","volume":"66","author":"RB Jones","year":"1990","unstructured":"Jones RB, Shpall EJ, Shogan J et al.: The Duke AFM program. Intensive induction chemotherapy for metastatic breast cancer. Cancer 66: 431\u2013436, 1990","journal-title":"Cancer"},{"key":"BF01807031_CR43","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1182\/blood.V73.7.1759.1759","volume":"73","author":"BY Ngan","year":"1989","unstructured":"Ngan BY, Nourse J, Cleary ML: Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas. Blood 73: 1759\u20131762, 1989","journal-title":"Blood"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01807031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01807031\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01807031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:06:13Z","timestamp":1586304373000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01807031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["BF01807031"],"URL":"https:\/\/doi.org\/10.1007\/bf01807031","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}