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Regulation of synthesis involves altered gene expression. The protein is fairly rapidly degraded when zinc is the primary metal species bound, but the degradation rate is diminished when cadmium or copper are bound as well. The net result of metallothionein production seems to be accumulation of bound metal and\/or intracellular metal redistribution. The accumulation of copper in various tissues of individuals with Menkes' and Wilson's diseases may be related to altered metallothionein turnover. The physiological function is not clear, but the response of metallothionein to hormonal stimuli is suggestive of an important role in cellular metabolism.<\/jats:p>","DOI":"10.1007\/bf01811318","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T19:32:36Z","timestamp":1119900756000},"page":"15-21","source":"Crossref","is-referenced-by-count":59,"title":["Metallothionein \u2014 Aspects related to copper and zinc metabolism"],"prefix":"10.1002","volume":"6","author":[{"given":"R. J.","family":"Cousins","sequence":"first","affiliation":[{"name":"Department of Food Science &amp; Human Nutrition University of Florida  Gainesville Florida 32611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1750841"},{"key":"e_1_2_1_3_1","volume-title":"Biological Roles of Metallothionein","author":"Bell J. 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