{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:54:50Z","timestamp":1760014490402},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The peroxisomal disorders can be divided into three classes: firstly, those in which the activity of only one single enzyme is reduced; secondly, those in which the activities of multiple peroxisomal enzymes are deficient and also the number of peroxisomes is reduced; and thirdly, those in which the activities of multiple peroxisomal enzymes are lacking and at the same time the number of peroxisomes is normal at least in liver tissue. The cerebro\u2010hepato\u2010renal syndrome of Zellweger is the prototype of peroxisomal disorders of the second group. Clinical distinction between Zellweger syndrome and neonatal adrenoleukodystrophy or infantile Refsum disease can be impossible. The clinical abnormalities that should give rise to suspicion for the presence of a peroxisomal disorder and urge the necessity of further biochemical studies are proposed.<\/jats:p>","DOI":"10.1007\/bf01812844","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T19:20:56Z","timestamp":1119900056000},"page":"23-32","source":"Crossref","is-referenced-by-count":19,"title":["Peroxisomal disorders: Clinical characterization"],"prefix":"10.1002","volume":"10","author":[{"given":"L.","family":"Monnens","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Nijmegen  Geert Grooteplein Zuid 20 Nijmegen 6525 GA The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Heymans","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Amsterdam  Meibergdreef 9 Amsterdam 1105 AZ The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"402","article-title":"A familial syndrome of multiple congenital defects","volume":"114","author":"Bowen P.","year":"1964","journal-title":"Bull. 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