{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:09:56Z","timestamp":1762322996374},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1984,5,9]],"date-time":"1984-05-09T00:00:00Z","timestamp":452908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In attempting to determine the effects of mildly elevated maternal phenylalanine (Phe) blood levels on the developing fetal rat brain, a dietary supplement of Phe was given, under taste cover of Aspartame. Phe and tyrosine (Tyr) levels were mildly elevated throughout pregnancy without evidence of malnutrition. Mild hyperphenylalaninaemia with concurrent hypertyrosinaemia induced in rats prior to conception resulted in microcephaly and lasting behavioural problems in the offspring, specifically hyperactivity and learning difficulties. Dams fed Tyr to produce Tyr levels equivalent to the Phe\u2010fed animals showed only the learning difficulties among the offspring.<\/jats:p><jats:p>\u03b1\u2010Methyl Phe, a Phe hydroxylase inhibitor, fed in conjunction with Phe, at the level relevant to these experiments, resulted in raised Tyr levels and does not provide a better method of determining whether mildly elevated maternal Phe levels alone, or Phe and Tyr in combination, cause the abnormality found in the offspring of Phe\u2010supplemented dams.<\/jats:p><jats:p>Therapeutic addition of Tyr to diets of mothers with even mild hyperphenylalaninaemia should be approached with caution as mild co\u2010elevation of Phe and Tyr in the fetus may be harmful.<\/jats:p><jats:p>In the face of such a possible therapeutic dilemma alternatives, such as dietary additions of other essential amino acids to limit fetal brain damage, need to be explored.<\/jats:p>","DOI":"10.1007\/bf01819292","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T17:57:26Z","timestamp":1119895046000},"page":"113-117","source":"Crossref","is-referenced-by-count":11,"title":["Outcome of pregnancy in the rat with mild hyperphenylalaninaemia and hypertyrosinaemia: Implications for the management of \u201chuman maternal PKU\u201d"],"prefix":"10.1002","volume":"8","author":[{"given":"S. A.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Department of Community Health University of Auckland School of Medicine  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. C. T.","family":"Lyon","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Department of Community Health University of Auckland School of Medicine  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. B.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Department of Community Health University of Auckland School of Medicine  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,5,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.4.863"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197601000-00003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3953.81"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1700449b"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197711010-00002"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529425"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(79)90082-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1740931"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0048903"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198011203032104"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198311243092101"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1968.tb06202.x"},{"key":"e_1_2_1_14_1","first-page":"306","article-title":"Transient neonatal tyrosinaemia in neonatal screening","volume":"606","author":"Rice D. N.","year":"1983","journal-title":"Exerpta Medica Int. Congr. Series"},{"key":"e_1_2_1_15_1","volume-title":"Toxicology Report","author":"G. D. Searle & Co.","year":"1972"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-108-26929"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01819292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF01819292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T20:54:59Z","timestamp":1694897699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF01819292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,9]]}},"alternative-id":["10.1007\/BF01819292"],"URL":"https:\/\/doi.org\/10.1007\/bf01819292","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5,9]]}}}