{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:51:44Z","timestamp":1760853104538},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Membrain Biol."],"published-print":{"date-parts":[[1991,4]]},"DOI":"10.1007\/bf01870652","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T18:57:15Z","timestamp":1120244235000},"page":"67-78","source":"Crossref","is-referenced-by-count":51,"title":["Effects of the anesthetics heptanol, halothane and isoflurane on gap junction conductance in crayfish septate axons: A calcium- and hydrogen-independent phenomenon potentiated by caffeine and theophylline, and inhibited by 4-aminopyridine"],"prefix":"10.1007","volume":"121","author":[{"given":"Camillo","family":"Peracchia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01870652_CR1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1113\/jphysiol.1981.sp013762","volume":"315","author":"F.J. Alvarez-Leefmans","year":"1981","unstructured":"Alvarez-Leefmans, F.J., Rink, T.J., Tsien, R.W. 1981. Free calcium ions in neurons ofHelix aspersa measured with ionselective microelectrodes.J. Physiol. 315:531\u2013548","journal-title":"J. Physiol."},{"key":"BF01870652_CR2","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1021\/ac00237a031","volume":"53","author":"D. Ammann","year":"1981","unstructured":"Ammann, D., Lanter, F., Steiner, R.A., Schulthess, P., Shijo, Y., Simon, W. 1981. Neutral carrier based hydrogen ion selective microelectrode for extra- and intracellular studies.Anal. Chem. 53:2267\u20132269","journal-title":"Anal. Chem."},{"key":"BF01870652_CR3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1139\/y87-141","volume":"65","author":"D. Ammann","year":"1987","unstructured":"Ammann, D., Oesch, U., B\u00fchrer, T., Simon, W. 1987. Design of ionophores for ion-selective microsensors.Can. J. Physiol. Pharmacol. 65:879\u2013884","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"BF01870652_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1085\/jgp.77.3.233","volume":"77","author":"B.P. Bean","year":"1981","unstructured":"Bean, B.P., Shrager, P., Goldstein, D.A. 1981. Modification of sodium and potassium channel kinetics by ether and halothane.J. Gen. Physiol. 77:233\u2013253","journal-title":"J. Gen. Physiol."},{"key":"BF01870652_CR5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1749-6632.1966.tb50178.x","volume":"37","author":"M.V.L. Bennett","year":"1966","unstructured":"Bennett, M.V.L. 1966. Physiology of electrotonic junctions.Ann. N.Y. Acad. Sci. 37:509\u2013539","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"BF01870652_CR6","first-page":"307","volume":"34","author":"G. Bernardini","year":"1984","unstructured":"Bernardini, G., Peracchia, C., Peracchia, L.L. 1984. Reversible effects of heptanol on gap junction structure and cell-to-cell electrical coupling.Eur. J. Cell Biol. 34:307\u2013312","journal-title":"Eur. J. Cell Biol."},{"key":"BF01870652_CR7","doi-asserted-by":"crossref","first-page":"C913","DOI":"10.1152\/ajpcell.1989.256.4.C913","volume":"256","author":"J.M. Burt","year":"1989","unstructured":"Burt, J.M. 1989. Uncoupling of cardiac cells by doxyl stearic acids: Specificity and mechanism of action.Am. J. Physiol. 256:C913-C924","journal-title":"Am. J. Physiol."},{"key":"BF01870652_CR8","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1073\/pnas.85.10.3431","volume":"85","author":"J.M. Burt","year":"1988","unstructured":"Burt, J.M., Spray, D.C. 1988. Single channel events and gating behavior of the cardiac gap junction channel.Proc. Natl. Acad. Sci. USA 85:3431\u20133434","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF01870652_CR9","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0021-9258(18)60316-3","volume":"237","author":"R.W. Butcher","year":"1962","unstructured":"Butcher, R.W., Sutherland, E.W. 1962. Adenosine 3\u2032, 5\u2032-phosphate in biological materials: I. Purification and properties of cyclic 3\u2032, 5\u2032-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3\u2032, 5\u2032-phosphate in human urine.J. Biol. Chem. 237:1244\u20131250","journal-title":"J. Biol. Chem."},{"key":"BF01870652_CR10","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/0024-3205(81)90614-7","volume":"28","author":"J.W. Daly","year":"1981","unstructured":"Daly, J.W., Bruns, R.F., Snyder, S.H. 1981. Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines.Life Sci. 28:2083\u20132097","journal-title":"Life Sci."},{"key":"BF01870652_CR11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF02332124","volume":"74","author":"J. D\u00e9l\u00e8ze","year":"1983","unstructured":"D\u00e9l\u00e8ze, J., Herv\u00e9, J.C. 1983. Effect of several uncouplers of cell-to-cell communication on gap junction morphology in mammalian heart.J. Membrane Biol. 74:203\u2013215","journal-title":"J. Membrane Biol."},{"key":"BF01870652_CR12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01871014","volume":"93","author":"J. D\u00e9l\u00e8ze","year":"1986","unstructured":"D\u00e9l\u00e8ze, J., Herv\u00e9, J.C. 1986. Quantitative gap junction alterations in mammalian heart cells quickly frozen or chemically fixed after electrical uncoupling.J. Membrane Biol. 93:11\u201321","journal-title":"J. Membrane Biol."},{"key":"BF01870652_CR13","volume-title":"Caffeine\u2014Perspectives from Recent Research","year":"1984","unstructured":"Dews, P.B. (editor) 1984. Caffeine\u2014Perspectives from Recent Research. Springer-Verlag. New York"},{"key":"BF01870652_CR14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0166-2236(88)90198-1","volume":"11","author":"M. Fill","year":"1988","unstructured":"Fill, M., Coronado, R. 1988. Ryanodine receptor channel of sarcoplasmic reticulum.Trends Neurosci. 11:453\u2013457","journal-title":"Trends Neurosci."},{"key":"BF01870652_CR15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/300487a0","volume":"300","author":"N.P. Franks","year":"1982","unstructured":"Franks, N.P., Lieb, W.R. 1982. Molecular mechanisms of general anaesthesia.Nature 300:487\u2013492","journal-title":"Nature"},{"key":"BF01870652_CR16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0006-291X(85)90300-6","volume":"126","author":"H.C. Gainer","year":"1985","unstructured":"Gainer, H.C., Murray, A.W. 1985. Diacylglycerol inhibits gap junction communication in cultured epidermal cells: Evidence for role of protein kinase C.Biochem. Biophys. Res. Commun. 126:1109\u20131113","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF01870652_CR17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00583541","volume":"413","author":"C. Giaume","year":"1989","unstructured":"Giaume, C., Randriamampita, C., Trautmann, A. 1989. Arachidonic acid closes gap junction channels in rat lacrimal glands.Pfluegers Arch. 413:273\u2013279","journal-title":"Pfluegers Arch."},{"key":"BF01870652_CR18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1161\/01.RES.24.5.745","volume":"24","author":"O. Hauswirth","year":"1969","unstructured":"Hauswirth, O. 1969. Effects of halothane on single atrial, ventricular, and Purkinje fibers.Circ. Res. 24:745\u2013750","journal-title":"Circ. Res."},{"key":"BF01870652_CR19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00582558","volume":"405","author":"G. Hirche","year":"1984","unstructured":"Hirche, G. 1984. Blocking and modifying actions of octanol on Na channels in frog myelinated nerve,Pfluegers Arch. 405:180\u2013187","journal-title":"Pfluegers Arch."},{"key":"BF01870652_CR20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0070-2161(08)60481-5","volume":"22","author":"D.A. Hydon","year":"1984","unstructured":"Hydon, D.A., Elliott, J.R., Hendry, B.M. 1984. Effects of anesthetics on the squid giant axon.Curr. Top. Membr. Transp. 22:445\u2013482","journal-title":"Curr. Top. Membr. Transp."},{"key":"BF01870652_CR21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1113\/jphysiol.1981.sp013840","volume":"317","author":"M.F. Johnston","year":"1981","unstructured":"Johnston, M.F., Ramon, F. 1981. Electrotonic coupling in internally perfused crayfish segmented axons.J. Physiol. 317:509\u2013518","journal-title":"J. Physiol."},{"key":"BF01870652_CR22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/286498a0","volume":"286","author":"M.F. Johnston","year":"1980","unstructured":"Johnston, M.F., Simon, S.A., Ramon, F. 1980. Interaction of anesthetics with electrical synapses.Nature 286:498\u2013500","journal-title":"Nature"},{"key":"BF01870652_CR23","first-page":"73","volume":"17","author":"G.L. Kramer","year":"1980","unstructured":"Kramer, G.L., Wells, J.N. 1980. Xanthines and skeletal muscle: Lack of relationship between phosphodiesterase inhibition and increased twitch tension in rat diaphragms.Mol. Pharmacol. 17:73\u201378","journal-title":"Mol. Pharmacol."},{"key":"BF01870652_CR24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1981.61.4.829","volume":"61","author":"W.R. Loewenstein","year":"1981","unstructured":"Loewenstein, W.R. 1981. Junctional intercellular communication: The cell-to-cell membrane channel.Physiol. Rev. 61:829\u2013913","journal-title":"Physiol. Rev."},{"key":"BF01870652_CR25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00000542-198110000-00005","volume":"55","author":"C. Lynch","year":"1981","unstructured":"Lynch, C., Vogel, S., Pratila, M.G., Sperelakis, N. 1981. Halothane depression of myocardial slow action potentials.Anesthesiology 55:360\u2013368","journal-title":"Anesthesiology"},{"key":"BF01870652_CR26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1083\/jcb.103.2.475","volume":"103","author":"P. Meda","year":"1986","unstructured":"Meda, P., Bruzzone, R., Knodel, S., Orci, L. 1986. Blockage of cell-to-cell communication within pancreatic acini is associated with increased release of amylase.J. Cell Biol. 103:475\u2013483","journal-title":"J. Cell Biol."},{"key":"BF01870652_CR27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0006-291X(79)91535-3","volume":"91","author":"A.W. Murray","year":"1979","unstructured":"Murray, A.W., Fitzgerald, D.J. 1979. Tumor promoters inhibit metabolic cooperation in coculture of epidermal and 3T3 cells.Biochem. Biophys. Res. Commun. 91:395\u2013401","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF01870652_CR28","doi-asserted-by":"crossref","first-page":"C273","DOI":"10.1152\/ajpcell.1989.256.2.C273","volume":"256","author":"E. Niggli","year":"1989","unstructured":"Niggli, E., R\u00fcdis\u00fcli, A., Maurer, P., Weingart, R. 1989. Effects of general anesthetics on current flow across membranes of guinea pig myocytes.Am. J. Physiol. 256:C273-C281","journal-title":"Am. J. Physiol."},{"key":"BF01870652_CR29","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1016\/S0021-9258(19)68885-X","volume":"256","author":"V. Niggli","year":"1981","unstructured":"Niggli, V., Aduryach, E.S., Carafoli, E. 1981. Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca++-ATPase.J. Biol. Chem. 256:8588\u20138592","journal-title":"J. Biol. Chem."},{"key":"BF01870652_CR30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0006-3495(79)85273-X","volume":"26","author":"G.S. Oxford","year":"1979","unstructured":"Oxford, G.S., Swenson, R.P. 1979.n-Alkanols potentiate sodium channel inactivation in squid axon.Biophys. J. 26:585\u2013590","journal-title":"Biophys. J."},{"key":"BF01870652_CR31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0074-7696(08)61972-5","volume":"66","author":"C. Peracchia","year":"1980","unstructured":"Peracchia, C. 1980. Structural correlates of gap junction permeation.Int. Rev. Cytol. 66:81\u2013146","journal-title":"Int. Rev. Cytol."},{"key":"BF01870652_CR32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4613-1917-7_3","volume-title":"Cell-to-Cell Communication","author":"C. Peracchia","year":"1987","unstructured":"Peracchia, C. 1987. Permeability and regulation of gap junction channels in cells and in artificial lipid bilayers.In: Cell-to-Cell Communication. W.C. DeMello, editor. pp. 65\u2013102. Plenum. New York"},{"key":"BF01870652_CR33","first-page":"267","volume-title":"Gap Junctions","author":"C. Peracchia","year":"1988","unstructured":"Peracchia, C. 1988. The calmodulin hypothesis for gap junction regulation six years later.In: Gap Junctions. E.L. Hertzberg and R.G. Johnson, editors. pp. 267\u2013282. Alan R. Liss, New York"},{"key":"BF01870652_CR34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF01871567","volume":"117","author":"C. Peracchia","year":"1990","unstructured":"Peracchia, C. 1990a. Effects of caffeine and ryanodine on low pH 1 -induced changes in gap junction conductance and calcium concentration in crayfish septate axons.J. Membrane Biol. 117:79\u201389","journal-title":"J. Membrane Biol."},{"key":"BF01870652_CR35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01869608","volume":"113","author":"C. Peracchia","year":"1990","unstructured":"Peracchia, C. 1990b. Increase in gap junction resistance with acdification in crayfish septate axons is closely related to changes in intracellular calcium but not hydrogen ion concentration.J. Membrane Biol. 113:75\u201392","journal-title":"J. Membrane Biol."},{"key":"BF01870652_CR36","first-page":"613","volume":"6","author":"C. Peracchia","year":"1989","unstructured":"Peracchia, C., Girsch, S.J. 1989. Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26.Lens Eye Toxic. Res. 6:613\u2013621","journal-title":"Lens Eye Toxic. Res."},{"key":"BF01870652_CR37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0079-6107(86)90010-6","volume":"48","author":"F. Ramon","year":"1987","unstructured":"Ramon, F., Rivera, A. 1987. Gap junction channel modulation: A physiological viewpoint.Prog. Biophys. 48:127\u2013153","journal-title":"Prog. Biophys."},{"key":"BF01870652_CR38","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1085\/jgp.85.6.789","volume":"85","author":"J. Requena","year":"1985","unstructured":"Requena, J., Whittembury, J., Tiffert, T., Eisner, D.A., Mullins, L.J. 1985. The influence of chemical agents on the level of ionized [Ca++] in squid axons.J. Gen. Physiol. 85:789\u2013804","journal-title":"J. Gen. Physiol."},{"key":"BF01870652_CR39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01870926","volume":"104","author":"N. Rodriguez","year":"1988","unstructured":"Rodriguez, N., Villegas, R., Requena, J. 1988. The interaction of homologous series of alkanols with sodium channels in nerve membrane vesicles.J. Membrane Biol. 104:139\u2013146","journal-title":"J. Membrane Biol."},{"key":"BF01870652_CR40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF00373136","volume":"415","author":"A. R\u00fcdis\u00fcli","year":"1989","unstructured":"R\u00fcdis\u00fcli, A., Weingart, R. 1989. Electrical properties of gap junction channels in guinea-pig ventricular cell pairs revealed by exposure to heptanol.Pfluegers Arch. 415:12\u201321","journal-title":"Pfluegers Arch."},{"key":"BF01870652_CR41","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1021\/ac00124a036","volume":"58","author":"U. Schefer","year":"1986","unstructured":"Schefer, U., Ammann, D., Pretsch, E., Oesch, U., Simon, W. 1986. Neutral carrier based Ca++-selective electrode with detection limit in the subnanomolar range.Anal. Chem. 58:2282\u20132285","journal-title":"Anal. Chem."},{"key":"BF01870652_CR42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/BF00583731","volume":"412","author":"R. Somogyi","year":"1988","unstructured":"Somogyi, R., Kolb, H.-A. 1988. Cell-to-cell channel conductance during loss of gap junctional coupling in pairs of pancreatic acinar and Chinese hamster ovary cells.Pfluegers Arch. 412:54\u201365","journal-title":"Pfluegers Arch."},{"key":"BF01870652_CR43","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.1990.258.2.C195","volume":"258","author":"D.C. Spray","year":"1990","unstructured":"Spray, D.C., Burt, J.M. 1990. Structure-activity relations of the cardiac gap junction channel.Am. J. Physiol. 258:C195-C205","journal-title":"Am. J. Physiol."},{"key":"BF01870652_CR44","doi-asserted-by":"crossref","first-page":"11078","DOI":"10.1016\/S0021-9258(19)70253-1","volume":"255","author":"T. Tanaka","year":"1980","unstructured":"Tanaka, T., Hidaka, H. 1980. Hydrophobic regions function in calmodulin-enzyme(s) interactions.J. Biol. Chem. 255: 11078\u201311080","journal-title":"J. Biol. Chem."},{"key":"BF01870652_CR45","first-page":"355","volume":"15","author":"D.A. Twombly","year":"1989","unstructured":"Twombly, D.A., Narahashi, T. 1989. Calcium channel blocking action of octanol.Soc. Neurosci. Abstr. 15:355","journal-title":"Soc. Neurosci. Abstr."},{"key":"BF01870652_CR46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0006-3495(86)83434-8","volume":"50","author":"G. Vassort","year":"1986","unstructured":"Vassort, G., Whittembury, J., Mullins, L.J. 1986. Increase in internal Ca++ and decrease in internal H+ are induced by general anesthetics in squid axons.Biophys. J. 50:11\u201319","journal-title":"Biophys. J."},{"key":"BF01870652_CR47","first-page":"H170","volume":"254","author":"R.D. Veenstra","year":"1988","unstructured":"Veenstra, R.D., De Haan, R.L. 1988. Cardiac gap junction channel activity in embryonic chick ventricle cells.Am. J. Physiol. 254:H170-H180","journal-title":"Am. J. Physiol."},{"key":"BF01870652_CR48","doi-asserted-by":"crossref","first-page":"C447","DOI":"10.1152\/ajpcell.1985.249.5.C447","volume":"249","author":"R.L. White","year":"1985","unstructured":"White, R.L., Spray, D.C., Campos de Carvalho, A.C., Wittenberg, B.A., Bennett, M.V.L. 1985. Some electrical and pharmacological properties of gap junctions between adult rat ventricular myocytes.Am. J. Physiol. 249:C447-C455","journal-title":"Am. J. Physiol."},{"key":"BF01870652_CR49","first-page":"167","volume-title":"Gap Junctions","author":"J.A. Wojtczak","year":"1985","unstructured":"Wojtczak, J.A. 1985. Electrical uncoupling induced by general anesthetics: A calcium-independent process?In: Gap Junctions. M.V.L. Bennett and D.C. Spray, editors. pp. 167\u2013175. Cold Spring Harbor Laboratories. Cold Spring Harbor, New York"},{"key":"BF01870652_CR50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01871087","volume":"88","author":"T. Yada","year":"1985","unstructured":"Yada, T., Rose, B., Loewenstein, W.R. 1985. Diacylglycerol downregulates junctional membrane permeability. TMB-8 blocks this effect.J. Membrane Biol. 88:217\u2013232","journal-title":"J. Membrane Biol."},{"key":"BF01870652_CR51","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.493994","volume":"206","author":"L.P. Yotti","year":"1979","unstructured":"Yotti, L.P., Chang, C.C., Trosko, J.E. 1979. Elimination of metabolic cooperation in chinese hamster cells by a tumor promoter.Science 206:1089\u20131091","journal-title":"Science"}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01870652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01870652\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01870652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T21:38:26Z","timestamp":1626125906000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01870652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["BF01870652"],"URL":"https:\/\/doi.org\/10.1007\/bf01870652","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4]]}}}