{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:34:12Z","timestamp":1771623252886,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1971,3,1]],"date-time":"1971-03-01T00:00:00Z","timestamp":36633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Membrain Biol."],"published-print":{"date-parts":[[1971,3]]},"DOI":"10.1007\/bf01874114","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T22:21:08Z","timestamp":1120256468000},"page":"58-80","source":"Crossref","is-referenced-by-count":66,"title":["In vitro excitation of purified membrane fragments by cholinergic agonists"],"prefix":"10.1007","volume":"6","author":[{"given":"Michiki","family":"Kasai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Changeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01874114_CR1","first-page":"109","volume-title":"Regulation of Enzyme Activity and Allosteric Interactions","author":"M. H. Buc","year":"1968","unstructured":"Buc, M. H., Buc, H. 1968. Allosteric interactions between AMP and orthophosphate sites on phosphorylase b from rabbit muscle.In: Regulation of Enzyme Activity and Allosteric Interactions. E. Kvamme and A. Pihl, editors. p. 109. Universitetsforlaget, Oslo."},{"key":"BF01874114_CR2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/SQB.1961.026.01.037","volume":"26","author":"J.-P. Changeux","year":"1961","unstructured":"Changeux, J.-P. 1961. The feed-back control mechanism of biosyntheticl-threonine deaminase byl-isoleucine.Cold Spring Harbor Symp. Quant. Biol. 26:313.","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"BF01874114_CR3","first-page":"369","volume":"2","author":"J.-P. Changeux","year":"1966","unstructured":"\u2014 1966. Responses of acetylcholinesterase fromTorpedo marmorata to salts and curarizing drugs.Mol. Pharmacol. 2:369.","journal-title":"Mol. Pharmacol."},{"key":"BF01874114_CR4","series-title":"Nobel Symp.","first-page":"235","volume-title":"Symmetry and Function of Biological Systems at the Macromolecular Level","author":"J.-P. Changeux","year":"1969","unstructured":"\u2014 1969. Remarks on the symmetry and cooperative properties of biological membranes.In: Symmetry and Function of Biological Systems at the Macromolecular Level. A. Engstr\u00f6m and B. Strandberg, editors,Nobel Symp., vol. 11, p. 235. Wiley, Interscience Division, New York."},{"key":"BF01874114_CR5","first-page":"197","volume-title":"Ciba Symposium, Molecular properties of Drug Receptors","author":"J.-P. Changeux","year":"1970","unstructured":"\u2014 Blumenthal, R., Kasai, M., Podleski, T. R. 1970. Conformational transitions in the course of membrane excitation.In: Ciba Symposium, Molecular properties of Drug Receptors. R. Porter and M. O'Connor, editors p. 197. Churchill, London."},{"key":"BF01874114_CR6","first-page":"2864","volume":"270","author":"J.-P. Changeux","year":"1970","unstructured":"\u2014, Kasai, M., Huchet, M., Meunier, J. C. 1970a. Extraction \u00e0 partir du tissu \u00e9lectrique de gymnote d'une prot\u00e9ine pr\u00e9sentant plusieurs propri\u00e9t\u00e9s caract\u00e9ristiques du r\u00e9cepteur physiologique de l'ac\u00e9tylcholine.Compt. Rend. Acad. Sci. Paris 270:2864.","journal-title":"Compt. Rend. Acad. Sci. Paris"},{"key":"BF01874114_CR7","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1073\/pnas.67.3.1241","volume":"67","author":"J.-P. Changeux","year":"1970","unstructured":"\u2014\u2014, Lee, C. Y. 1970b. The use of a snake venom toxin to characterize the cholinergic receptor protein.Proc. Nat. Acad. Sci. 67:1241.","journal-title":"Proc. Nat. Acad. Sci."},{"key":"BF01874114_CR8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0014-5793(68)80105-X","volume":"2","author":"J.-P. Changeux","year":"1968","unstructured":"\u2014, Leuzinger, W., Huchet M. 1968. Specific binding of acetylcholine to acetylcholinesterase in the presence of eserine.F.E.B.S. Letters 2:77.","journal-title":"F.E.B.S. Letters"},{"key":"BF01874114_CR9","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1073\/pnas.59.3.944","volume":"59","author":"J.-P. Changeux","year":"1968","unstructured":"\u2014, Podleski, T. R. 1968. On the excitability and cooperativity of the electroplax membrane.Proc. Nat. Acad. Sci. 59:944.","journal-title":"Proc. Nat. Acad. Sci."},{"key":"BF01874114_CR10","first-page":"123","volume-title":"Excitatory Synaptic Mechanisms","author":"J.-P. Changeux","year":"1970","unstructured":"\u2014\u2014, Kasai, M., Blumenthal, R. 1970. Some molecular aspects of membrane excitation studied with the eel electroplax.In: Excitatory Synaptic Mechanisms. P. Andersen and J. Jansen, editors. p. 123. Universitetsforlaget, Oslo."},{"key":"BF01874114_CR11","doi-asserted-by":"crossref","unstructured":"Changeux, J.-P., Podleski, T. R., Meunier, J. C. 1969. On some structural analogies between acetylcholinesterase and the macromolecular receptor of acetylcholine.J. Gen. Physiol. 54: 225 S.","DOI":"10.1085\/jgp.54.1.225"},{"key":"BF01874114_CR12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/bi00842a601","volume":"7","author":"J.-P. Changeux","year":"1968","unstructured":"\u2014, Rubin, M. M. 1968. Allosteric interactions in aspartate transcarbamylase. III. Interpretations of experimental data in terms of the model of Monod, Wyman and Changeux?Biochemistry 7:553.","journal-title":"Biochemistry"},{"key":"BF01874114_CR13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1073\/pnas.57.2.335","volume":"57","author":"J.-P. Changeux","year":"1967","unstructured":"\u2014, Thi\u00e9ry, J., Tung, Y., Kittel, C., 1967. On the cooperativity of biological membranes.Proc. Nat. Acad. Sci. 57:335.","journal-title":"Proc. Nat. Acad. Sci."},{"key":"BF01874114_CR14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.55.1.119","volume":"55","author":"G. Ehrenstein","year":"1970","unstructured":"Ehrenstein, G., Lecar, H., Nossal, R. 1970. The nature of the negative resistance in bimolecular lipid membranes containing excitability inducing material.J. Gen. Physiol. 55:119.","journal-title":"J. Gen. Physiol."},{"key":"BF01874114_CR15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0021-9258(18)60389-8","volume":"237","author":"J. C. Gerhart","year":"1962","unstructured":"Gerhart, J. C., Pardee, A. B. 1962. The enzymology of control by feed-back inhibition.J. Biol. Chem. 237:891.","journal-title":"J. Biol. Chem."},{"key":"BF01874114_CR16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1021\/bi00882a012","volume":"4","author":"J. C. Gerhart","year":"1965","unstructured":"\u2014, Schachman, H. K. 1965. Distinct subunits for the regulation and catalytic activity of aspartate transcarbamylase.Biochemistry 4:1054.","journal-title":"Biochemistry"},{"key":"BF01874114_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0079-6107(70)90022-2","volume":"21","author":"B. Hille","year":"1970","unstructured":"Hille, B. 1970. Ionic channels in nerve membranes.Prog. Biophys. Mol. Biol. 21:1.","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"BF01874114_CR18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0005-2736(69)90061-3","volume":"193","author":"S. M. Johnson","year":"1969","unstructured":"Johnson, S. M., Bangham, A. D. 1969. Potassium permeability of single compartment liposomes with and without valinomycin.Biochim. Biophys. Acta 193:82.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF01874114_CR19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0022-5193(67)90011-2","volume":"16","author":"A. Karlin","year":"1967","unstructured":"Karlin, A. 1967. On the application of a plausible model of allosteric proteins to the receptor for acetylcholine.J. Theoret. Biol. 16:306.","journal-title":"J. Theoret. Biol."},{"key":"BF01874114_CR20","doi-asserted-by":"crossref","unstructured":"Karlin, A. 1969. Chemical modification of the activity of the acetylcholine receptor.J. Gen. Physiol. 54: 245S.","DOI":"10.1085\/jgp.54.1.245"},{"key":"BF01874114_CR21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/9780470719763.ch12","volume-title":"Ciba Symposium, Molecular Properties of Drug Receptors","author":"A. Karlin","year":"1970","unstructured":"Karlin, A., Prives, J., Deal, W., Winnik, M. 1970. Counting acetylcholine receptors in the electroplax.In: Ciba Symposium, Molecular Properties of Drug Receptors. R. Porter and M. O'Connor, editors. p. 247. J. and A. Churchill, London."},{"key":"BF01874114_CR22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0006-291X(69)90581-6","volume":"36","author":"M. Kasai","year":"1969","unstructured":"Kasai, M., Changeux, J.-P., Monnerie, L. 1969.In vitro interaction of 1-anilino-8-naphthalene sulfonate with excitable membranes isolated from the electric organ ofElectrophorus electricus.Biochem. Biophys. Res. Commun. 36:420.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF01874114_CR23","first-page":"7","volume":"13","author":"M. Kasai","year":"1970","unstructured":"\u2014, Podleski, T. R., Changeux, J.-P. 1970. Some structural properties of excitable membranes labelled by fluorescent probes.F. E. B. S. Letters 13:7.","journal-title":"F. E. B. S. Letters"},{"key":"BF01874114_CR24","doi-asserted-by":"crossref","unstructured":"Kennedy, E. 1969. Studies on the lactose transport system inEscherichia coli. J. Gen. Physiol. 54:91 S.","DOI":"10.1085\/jgp.54.1.91"},{"key":"BF01874114_CR25","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1021\/bi00900a020","volume":"3","author":"L. Kremzner","year":"1964","unstructured":"Kremzner, L., Wilson, I. B. 1964. A partial characterization of acetylcholinesterase.Biochemistry 3:1902.","journal-title":"Biochemistry"},{"key":"BF01874114_CR26","first-page":"555","volume":"33","author":"C. Y. Lee","year":"1966","unstructured":"Lee, C. Y., Chang, C. C. 1966. Modes of action of purified toxins from Elapid venoms on neuromuscular transmission.Mem. Inst. Butantan. Simp. Internac. 33:555.","journal-title":"Mem. Inst. Butantan. Simp. Internac."},{"key":"BF01874114_CR27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1073\/pnas.57.2.446","volume":"57","author":"W. Leuzinger","year":"1967","unstructured":"Leuzinger, W., Baker, A. 1967. Acetylcholinesterase. I. Large scale purification, homogeneity, amino acid analysis.Proc. Nat. Acad. Sci. 57:446.","journal-title":"Proc. Nat. Acad. Sci."},{"key":"BF01874114_CR28","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1073\/pnas.59.2.620","volume":"59","author":"W. Leuzinger","year":"1968","unstructured":"\u2014\u2014, Cauvin, E. 1968. Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point.Proc. Nat. Acad. Sci. 59:620.","journal-title":"Proc. Nat. Acad. Sci."},{"key":"BF01874114_CR29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0022-2836(69)90470-7","volume":"40","author":"W. Leuzinger","year":"1969","unstructured":"\u2014, Goldberg, M., Cauvin, E. 1969. Molecular properties of acetylcholinesterase.J. Mol. Biol. 40:217.","journal-title":"J. Mol. Biol."},{"key":"BF01874114_CR30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1432-1033.1969.tb00794.x","volume":"11","author":"J. Massouli\u00e9","year":"1969","unstructured":"Massouli\u00e9, J., Ri\u00e9ger, F. 1969. L'ac\u00e9tylcholinest\u00e9rase des organes \u00e9lectriques de poissons (torpille et gymnote); complexes membranaires.Europ. J. Biochem. 11:441.","journal-title":"Europ. J. Biochem."},{"key":"BF01874114_CR31","first-page":"117","volume":"272","author":"J.-C. Meunier","year":"1971","unstructured":"Meunier, J.-C., Huchet, M., Boquet, P., Changeux, J.-P. 1971. S\u00e9paration de la prot\u00e9ine r\u00e9ceptrice de l'ac\u00e9tylcholine et de l'ac\u00e9tylcholinest\u00e9rase.Compt. Rend. Acad. Sci. (Paris) 272:117 D.","journal-title":"Compt. Rend. Acad. Sci. (Paris)"},{"key":"BF01874114_CR32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0022-2836(63)80091-1","volume":"6","author":"J. Monod","year":"1963","unstructured":"Monod, J., Changeux, J.-P., Jacob, J. 1963. Allosteric proteins and cellular control systems.J. Mol. Biol. 6:306.","journal-title":"J. Mol. Biol."},{"key":"BF01874114_CR33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-2836(65)80285-6","volume":"12","author":"J. Monod","year":"1965","unstructured":"\u2014, Wyman, J., Changeux, J.-P. 1965. On the nature of allosteric transitions: A plausible model.J. Mol. Biol. 12:88.","journal-title":"J. Mol. Biol."},{"key":"BF01874114_CR34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/jphysiol.1967.sp008126","volume":"188","author":"J. W. Moore","year":"1967","unstructured":"Moore, J. W., Narahashi, T., Shaw, T. I. 1967. An upper limit to the number of sodium channels in nerve membrane.J. Physiol. 188:99.","journal-title":"J. Physiol."},{"key":"BF01874114_CR35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0022-5193(68)90163-X","volume":"18","author":"P. Mueller","year":"1968","unstructured":"Mueller, P., Rudin, D. O. 1968. Resting and action potentials in experimental bimolecular lipid membranes.J. Theoret. Biol. 18:222.","journal-title":"J. Theoret. Biol."},{"key":"BF01874114_CR36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/217713a0","volume":"217","author":"P. Mueller","year":"1968","unstructured":"\u2014\u2014 1968. Action potentials induced in bimolecular lipid membranes.Nature 217:713.","journal-title":"Nature"},{"key":"BF01874114_CR37","volume-title":"Chemical and Molecular Basis of Nerve Activity","author":"D. Nachmansohn","year":"1959","unstructured":"Nachmansohn, D. 1959. Chemical and Molecular Basis of Nerve Activity. Academic Press, New York."},{"key":"BF01874114_CR38","doi-asserted-by":"crossref","unstructured":"Nachmansohn, D. 1969. Proteins of excitable membranes.J. Gen. Physiol. 54: 187 S.","DOI":"10.1085\/jgp.54.1.187"},{"key":"BF01874114_CR39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1073\/pnas.63.2.496","volume":"63","author":"R. D. O'Brien","year":"1969","unstructured":"O'Brien, R. D., Gilmour, L. P. 1969. A muscarone-binding material in electroplax and its relation to the acetylcholine receptor. I. Centrifugal assay.Proc.Nat. Acad. Sci. 63:496.","journal-title":"Proc.Nat. Acad. Sci."},{"key":"BF01874114_CR40","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1073\/pnas.65.2.438","volume":"65","author":"R. D. O'Brien","year":"1970","unstructured":"\u2014\u2014, Eldefrawi, M. E. 1970. A muscarone-binding material in electroplax and its relation to the acetylcholine receptor. II. Dialysis assay.Proc. Nat. Acad. Sci. 65:438.","journal-title":"Proc. Nat. Acad. Sci."},{"key":"BF01874114_CR41","first-page":"1437","volume":"240","author":"R. Post","year":"1965","unstructured":"Post, R., Sen, A. K., Rosenthal, A. S. 1965. A phosphorylated intermediate in adenosine triphosphate dependent sodium and potassium transport across kidney membranes.J. Mol. Chem. 240:1437.","journal-title":"J. Mol. Chem."},{"key":"BF01874114_CR42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1432-1033.1971.tb01248.x","volume":"18","author":"P. Wahl","year":"1971","unstructured":"Wahl, P., Kasai, M., Changeux, J.-P. 1971. A study on the motion of proteins in excitable membrane fragments by a nanosecond fluorescence polarization spectroscopy.Europ. J. Biochem. 18:332.","journal-title":"Europ. J. Biochem."},{"key":"BF01874114_CR43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0079-6107(70)90028-3","volume":"21","author":"E. Whitehead","year":"1970","unstructured":"Whitehead, E. 1970. The regulation of enzyme activity and allosteric transition.Prog. Biophys. Mol. Biol. 21:321.","journal-title":"Prog. Biophys. Mol. Biol."}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01874114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01874114\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01874114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:52:55Z","timestamp":1706370775000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01874114"}},"subtitle":["III. Comparison of the dose-response curves to decamethonium with the corresponding binding curves of decamethonium to the cholinergic receptor"],"short-title":[],"issued":{"date-parts":[[1971,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,3]]}},"alternative-id":["BF01874114"],"URL":"https:\/\/doi.org\/10.1007\/bf01874114","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,3]]}}}