{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:30:08Z","timestamp":1778830208163,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1986,2,1]],"date-time":"1986-02-01T00:00:00Z","timestamp":507600000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Tr"],"published-print":{"date-parts":[[1986,2]]},"DOI":"10.1007\/bf01886732","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T00:05:20Z","timestamp":1120694720000},"page":"23-30","source":"Crossref","is-referenced-by-count":85,"title":["Long-term survival following relapse after 5-FU but not CMF adjuvant breast cancer therapy"],"prefix":"10.1007","volume":"7","author":[{"given":"Rowan T.","family":"Chlebowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Luce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Bulcavage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01886732_CR1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0140-6736(83)92882-9","volume":"1","author":"G Bonadonna","year":"1983","unstructured":"Bonadonna G, Rossi A, Tancini G, Valagussa P: Adjuvant chemotherapy in breast cancer. Lancet 1: 1157, 1983","journal-title":"Lancet"},{"key":"BF01886732_CR2","first-page":"2882","volume":"39","author":"B Fisher","year":"1977","unstructured":"Fisher B, Glass A, Redmond C, Fisher ER, Baron B, Such E, Carbone P, Economou S, Foster R, Frelick R, Lerner H, Levitt M, Margolese R, MacFarlane J, Plotkin D, Shibata H, Volk H (and other cooperating investigators): L-phenylalanine mustard (L-PAM) in the management of primary breast cancer: and update of earlier findings and comparison with those utilizing L-PAM plus 5-fluorouracil (5-FU). Cancer 39: 2882\u20132903, 1977","journal-title":"Cancer"},{"key":"BF01886732_CR3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/1097-0142(19840201)53:3+<724::AID-CNCR2820531321>3.0.CO;2-8","volume":"53","author":"DL Ahmann","year":"1984","unstructured":"Ahmann DL: Status of adjuvant chemotherapy in patients with breast cancer. Cancer 53: 724\u2013729, 1984","journal-title":"Cancer"},{"key":"BF01886732_CR4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(84)92684-9","volume":"2","author":"A Howell","year":"1984","unstructured":"Howell A, George WD, Crowther D, Rubens RD, Bulbrook RD, Bush H, Howat JMT, Sellwood RA, Hayward JL, Fentiman IS, Chaudary M: Controlled trial of adjuvant chemotherapy with cyclophosphamide, methotrexate, and fluorouracil for breast cancer. Lancet 2: 307\u2013309, 1984","journal-title":"Lancet"},{"key":"BF01886732_CR5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1056\/NEJM197602192940801","volume":"294","author":"G Bonadonna","year":"1976","unstructured":"Bonadonna G, Brusamolino E, Valagussa P, Rossi A, Brugnatelli L, Brambilla C, DeLena M, Tancini G, Baretta E, Musumeci R, Veronesi U: Combination therapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294: 405\u2013410, 1976","journal-title":"N Engl J Med"},{"key":"BF01886732_CR6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM197501162920301","volume":"292","author":"B Fisher","year":"1975","unstructured":"Fisher B, Carbone P, Economou SG, Frelick R, Glass A, Lerner H, Redmond C, Zelen M, Band P, Katrych DL, Wolmark N, Fisher E (and other cooperating investigators): L-phenylalanine mustard (L-PAM) in the management of primary breast cancer: a report of early findings. N Engl J Med 292: 117\u2013122, 1975","journal-title":"N Engl J Med"},{"key":"BF01886732_CR7","first-page":"4399","volume":"41","author":"RT Chlebowski","year":"1981","unstructured":"Chlebowski RT, Weiner JM, Luce J, Hestorff R, Lang JE, Reynolds R, Godfrey T, Ryden VMJ, Bateman JR: Significance of relapse after adjuvant treatment with combination chemotherapy or 5-fluorouracil alone in high risk breast cancer. Cancer Res 41: 4399\u20134403, 1981","journal-title":"Cancer Res"},{"key":"BF01886732_CR8","first-page":"319","volume-title":"Breast Cancer: Diagnosis and Management","author":"SK Carter","year":"1984","unstructured":"Carter SK: Problems in the interpretation of breast cancer trials. In: Bonadonna G (ed): Breast Cancer: Diagnosis and Management. John Wiley and Sons, New York, 1984, pp 319\u2013335"},{"key":"BF01886732_CR9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457\u2013481, 1958","journal-title":"J Am Stat Assoc"},{"key":"BF01886732_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","volume":"35","author":"R Peto","year":"1977","unstructured":"Peto R, Pike MC, Armitage P, Brescow NE, Cox DR, Howard S, Mantel N, McPherson K, Peto J, Smith PG: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 35: 1\u201339, 1977","journal-title":"Br J Cancer"},{"key":"BF01886732_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF01805984","volume":"5","author":"G Bonadonna","year":"1985","unstructured":"Bonadonna G, Valagussa P, Rossi A, Tancini G, Brambilla C, Zambetti M, Veronesi U: Ten year experience with CMF-based adjuvant chemotherapy in resectable breast cancer. Breast Cancer Res Treat 5: 95\u2013115, 1985","journal-title":"Breast Cancer Res Treat"},{"key":"BF01886732_CR12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00000658-196809000-00004","volume":"168","author":"B Fisher","year":"1968","unstructured":"Fisher B, Ravdin RG, Ausman RK, Slack NH, Moore GE, Noer RJ: Surgical adjuvant chemotherapy in cancer of the breast: results of a decade of cooperative investigation. Ann Surg 168: 337\u2013341, 1968","journal-title":"Ann Surg"},{"key":"BF01886732_CR13","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/1097-0142(19811015)48:8<1711::AID-CNCR2820480804>3.0.CO;2-C","volume":"48","author":"RT Chlebowski","year":"1981","unstructured":"Chlebowski RT, Pugh RP, Weiner JM, Bateman JR: Treatment of advanced breast carcinoma with 5-fluorouracil: a randomized comparison of two routes of delivery. Cancer 48: 1711\u20131714, 1981","journal-title":"Cancer"},{"key":"BF01886732_CR14","first-page":"436","volume":"20","author":"RT Chlebowski","year":"1979","unstructured":"Chlebowski RT, Smalley RV, Weiner JM, Irwin LE, Bartolucci AA, Bateman JR: Combination versus sequential single agent chemotherapy in advanced breast cancer: relationships between survival and metastatic site. Proc Am Assoc Cancer Res 20: 436, 1979","journal-title":"Proc Am Assoc Cancer Res"},{"key":"BF01886732_CR15","first-page":"4503","volume":"39","author":"RT Chlebowski","year":"1979","unstructured":"Chlebowski RT, Irwin LE, Pugh RP, Sadoff L, Hestorff R, Weiner JM, Bateman JR: Survival of patients with metastatic breast cancer treated with either combination or sequential chemotherapy. Cancer Res 39: 4503\u20134506, 1979","journal-title":"Cancer Res"},{"key":"BF01886732_CR16","first-page":"3911","volume":"36","author":"RV Smalley","year":"1976","unstructured":"Smalley RV, Murphy S, Huguley CM Jr, Bartolucci AA: Combination versus sequential five drug chemotherapy in metastatic carcinoma of the breast. Cancer Res 36: 3911\u20133916, 1976","journal-title":"Cancer Res"},{"key":"BF01886732_CR17","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/1097-0142(19810915)48:6<1273::AID-CNCR2820480602>3.0.CO;2-3","volume":"48","author":"B Fisher","year":"1981","unstructured":"Fisher B, Redmond C, Wolmark N, Wieand HS: Diseasefree survival at intervals during and following completion of adjuvant chemotherapy: the NSABP experience from three breast cancer protocols. Cancer 48: 1273\u20131280, 1981","journal-title":"Cancer"},{"key":"BF01886732_CR18","first-page":"5","volume":"5","author":"J Dixon","year":"1978","unstructured":"Dixon J, Mority DA, Baker FL: Breast cancer and weight gain: an unexpected finding. Oncology Nursing Forum 5: 5\u20137, 1978","journal-title":"Oncology Nursing Forum"},{"key":"BF01886732_CR19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01805994","volume":"5","author":"KZ Heasman","year":"1985","unstructured":"Heasman KZ, Sutherland RN, Campbell JA, Elhakin T, Boyd NF: Weight gain during adjuvant chemotherapy for breast cancer. Breast Cancer Res Treat 5: 195\u2013200, 1985","journal-title":"Breast Cancer Res Treat"},{"key":"BF01886732_CR20","first-page":"339","volume":"4","author":"P Bonomi","year":"1984","unstructured":"Bonomi P, Bunting N, Fishman D, Wolter J, Hernandez B, Foltz A, Shorez W, Straus A, Anderson K, Roseman D, Economou S: Weight gain during adjuvant chemotherapy or hormono-chemotherapy for stage II breast cancer evaluated in relation to disease free survival. Breast Cancer Res Treat 4: 339, 1984","journal-title":"Breast Cancer Res Treat"},{"key":"BF01886732_CR21","first-page":"33","volume":"8","author":"CME Rowland-Payne","year":"1982","unstructured":"Rowland-Payne CME, Abbot M, Jones JM, Powles TJ, Coombes RC: Weight loss during therapy for advanced breast cancer. Clin Oncol 8: 33\u201338, 1982","journal-title":"Clin Oncol"},{"key":"BF01886732_CR22","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/1097-0142(197804)41:4<1590::AID-CNCR2820410449>3.0.CO;2-N","volume":"41","author":"WL Donegan","year":"1978","unstructured":"Donegan WL, Hartz AJ, Rimm AA: The association of body weight and recurrent cancer of the breast. Cancer 41: 1590\u20131599, 1978","journal-title":"Cancer"},{"key":"BF01886732_CR23","first-page":"785","volume":"67","author":"NF Boyd","year":"1981","unstructured":"Boyd NF, Campbell JE, Kermanson T, Thomson DB, Sutherland DJ, Meakin JW: Body weight and prognosis in breast cancer: J Natl Cancer Inst 67: 785\u2013789, 1981","journal-title":"J Natl Cancer Inst"},{"key":"BF01886732_CR24","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/1097-0142(19810501)47:9<2222::AID-CNCR2820470919>3.0.CO;2-5","volume":"47","author":"PI Tartter","year":"1981","unstructured":"Tartter PI, Papatestas AE, Ioannovich J, Mulvihill MN, Lesnick G, Aufses AH: Cholesterol and obesity as prognostic factors in breast cancer. Cancer 47: 2222\u20132227, 1981","journal-title":"Cancer"},{"key":"BF01886732_CR25","first-page":"59","volume":"2","author":"B Samoff","year":"1982","unstructured":"Samoff B, Gorzynski JG, Katz JL, Weiner H, Levin J, Holland J, Fukushima DK: Non-obesity at the time of mastectomy is highly predictive of 10 year disease free survival in women with breast cancer. Anticancer Res 2: 59\u201362, 1982","journal-title":"Anticancer Res"},{"key":"BF01886732_CR26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01807654","volume":"5","author":"T Eberlein","year":"1985","unstructured":"Eberlein T, Simon R, Fisher S, Lippman ME: Height, weight, and risk of breast cancer relapse. Breast Cancer Res Treat 5: 81\u201386, 1985","journal-title":"Breast Cancer Res Treat"},{"key":"BF01886732_CR27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF01806704","volume":"3","author":"J Coburn","year":"1983","unstructured":"Coburn J, Ahmann FR, Moon T, Jones JE: The effect of prior adjuvant chemotherapy on survival in metastatic breast cancer. Breast Cancer Res Treat 3: 303, 1983","journal-title":"Breast Cancer Res Treat"},{"key":"BF01886732_CR28","first-page":"114","volume":"3","author":"D Schapira","year":"1984","unstructured":"Schapira D, Velez-Garcia E, Raney M, Moore M, Greenberg J, Wang G, Vogel C: Salvage therapy for breast cancer patients relapsing after adjuvant therapy. Proc Am Soc Clin Oncol 3: 114, 1984","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF01886732_CR29","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/1097-0142(197903)43:3<956::AID-CNCR2820430326>3.0.CO;2-L","volume":"43","author":"DP Winchester","year":"1979","unstructured":"Winchester DP, Sener SF, Khandekar JD, Oviedo MA, Cunningham MP, Caprini JA, Burkett FE, Scanlon EF: Symptomatology as an indication of recurrent or metastatic breast cancer. Cancer 43: 956\u2013960, 1979","journal-title":"Cancer"},{"key":"BF01886732_CR30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF01806750","volume":"1","author":"P Valagussa","year":"1981","unstructured":"Valagussa P, Tesoro Tess JD, Rossi A, Tancini G, Banfi A, Bonadonna G: Adjuvant CMF effect on site of first recurrence, and appropriate follow-up intervals, in operable breast cancer with positive axillary nodes. Breast Cancer Res Treat 1: 349\u2013356, 1981","journal-title":"Breast Cancer Res Treat"},{"key":"BF01886732_CR31","first-page":"9","volume":"3","author":"A Buzdar","year":"1984","unstructured":"Buzdar A, Mahajan S, Hortobagyi G, Blumenschein G: Value of staging procedures for detection of recurrent disease in breast cancer patients and its impact on survival. Proc Am Soc Clin Oncol 3: 9, 1984","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF01886732_CR32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00000421-198302000-00007","volume":"6","author":"AV Buzdar","year":"1983","unstructured":"Buzdar AV, Blumenschein GR, Montague ED, Hortobagyi GN, Yap Y, Pinnamaneni K, Marcus CE, Smith TL: Combined modality approach in breast cancer with isolated or multiple metastasis. Am J Clin Oncol 6: 45\u201350, 1983","journal-title":"Am J Clin Oncol"},{"key":"BF01886732_CR33","first-page":"110","volume":"2","author":"TM Beck","year":"1983","unstructured":"Beck TM, Hart NE, Woodard DA, Smith CE: Local or regionally recurrent carcinoma of the breast: results of therapy in 121 patients. J Clin Oncol 2: 110\u2013115, 1983","journal-title":"J Clin Oncol"},{"key":"BF01886732_CR34","first-page":"110","volume":"2","author":"D Nemoto","year":"1983","unstructured":"Nemoto D: Metastatic breast cancer: prolonged complete response and possible cure by chemotherapy. Proc Am Soc Clin Oncol 2: 110, 1983","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF01886732_CR35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1200\/JCO.1983.1.2.138","volume":"1","author":"DC Tormey","year":"1983","unstructured":"Tormey DC, Weinberg VE, Holland JF, Weiss RB, Glidewell OJ, Perloff M, Falkson G, Falkson HC, Henry PH, Leone LA, Rafla S, Ginsberg SJ, Silver RT, Blom J, Carey RW, Schein PS, Lesnick GJ: A randomized trial of five and three drug chemotherapy and chemoimmunotherapy in women with operable node positive breast cancer. J Clin Oncol 1: 138, 1983","journal-title":"J Clin Oncol"},{"key":"BF01886732_CR36","first-page":"117","volume":"3","author":"H Muss","year":"1984","unstructured":"Muss H, Cooper R, Ferree C, Jackson D, Atkins J, Richards F, Spurr C, White D, Stuart J, McCulloch J, Green F, Harding R, Christian R, Capizzi R, Case D, Morgan T, Wells B: Long term follow-up of L-PAM and CMF with and without radiation therapy as adjuvant treatment for stage II breast carcinoma. Proc Am Soc Clin Oncol 3: 117, 1984","journal-title":"Proc Am Soc Clin Oncol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01886732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01886732\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01886732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T23:24:46Z","timestamp":1557444286000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01886732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,2]]}},"alternative-id":["BF01886732"],"URL":"https:\/\/doi.org\/10.1007\/bf01886732","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}