{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:36:42Z","timestamp":1773430602971,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experientia"],"published-print":{"date-parts":[[1996,5]]},"DOI":"10.1007\/bf01919317","type":"journal-article","created":{"date-parts":[[2005,7,23]],"date-time":"2005-07-23T03:21:58Z","timestamp":1122088918000},"page":"464-468","source":"Crossref","is-referenced-by-count":20,"title":["Is there a critical tissue oxygen tension for bioenergetic status and cellular pH regulation in solid tumors?"],"prefix":"10.1007","volume":"52","author":[{"given":"P.","family":"Vaupel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01919317_CR1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/mrm.1910020502","volume":"2","author":"D. A. Adams","year":"1985","unstructured":"Adams, D. A., Denardo, G. L., Denardo, S. J., Conboy, C. B., and Bradbury, E. M.,31P-NMR analysis of metabolic status in KHJJ tumors, Magnet. Reson. Med.2 (1985) 419.","journal-title":"Magnet. Reson. Med."},{"key":"BF01919317_CR2","volume-title":"Cellular energy metabolism and its regulation","author":"D. E. Atkinson","year":"1977","unstructured":"Atkinson, D. E., Cellular energy metabolism and its regulation. Academic Press, New York 1977."},{"key":"BF01919317_CR3","doi-asserted-by":"crossref","first-page":"C10","DOI":"10.1152\/ajpcell.1984.246.1.C10","volume":"246","author":"R. S. Balaban","year":"1984","unstructured":"Balaban, R. S., The application of nuclear magnetic resonance to the study of cellular physiology. Am. J. Physiol.246 (1984) C10-C19.","journal-title":"Am. J. Physiol."},{"key":"BF01919317_CR4","first-page":"R728","volume":"263","author":"R. W. Barbee","year":"1992","unstructured":"Barbee, R. W., Perry, B. D., R\u00e9, R. N., and Murgo, J. P., Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice. Am. J. Physiol.263 (1992) R728-R733.","journal-title":"Am. J. Physiol."},{"key":"BF01919317_CR5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jcp.1041240214","volume":"124","author":"S. K. Calderwood","year":"1985","unstructured":"Calderwood, S. K., Bump, E. A., Stevenson, M. A., Van Kersen, I., and Hahn, G. M., Investigation of adenylate energy charge, phosphorylation potential and ATP concentration in cells stressed with starvation and heat. J. Cell. Physiol.124 (1985) 261\u2013268.","journal-title":"J. Cell. Physiol."},{"key":"BF01919317_CR6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0005-2728(77)90186-4","volume":"462","author":"M. Erecinska","year":"1977","unstructured":"Erecinska, M., Stubbs, M., Miyata, Y., Ditre, C. M., and Wilson, D. F., Regulation of cellular metabolism by phosphate. Biochim. biophys. Acta462 (1977) 20\u201335.","journal-title":"Biochim. biophys. Acta"},{"key":"BF01919317_CR7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/mrm.1910010410","volume":"1","author":"W. T. Evanochko","year":"1984","unstructured":"Evanochko, W. T., Ng, T. C., and Glickson, J. D., Application of in vivo NMR spectroscopy to cancer. Magn. Reson. Med.1 (1984) 508\u2013534.","journal-title":"Magn. Reson. Med."},{"key":"BF01919317_CR8","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(90)90307-6","volume":"18","author":"K. K. Fu","year":"1990","unstructured":"Fu, K. K., Wendland, M. F., Iyer, S. B., Lam, K. N., Engeseth, H., and James, T. L., Correlations between in vivo31P NMR spectroscopy measurements, tumor size, hypoxic fraction and cell survival after radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.18 (1990) 1341\u20131350.","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BF01919317_CR9","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0360-3016(92)90011-6","volume":"23","author":"L. E. Gerweck","year":"1992","unstructured":"Gerweck, L. E., Koutcher, J. A., Zaidi, S. T. H., and Seneviratne, T., Energy status in the murine FSaII and MCaIV tumors under aerobic and hypoxic conditions: an in-vivo and in-vitro analysis. Int. J. Radiat. Oncol. Biol. Phys.23 (1992) 557\u2013561.","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BF01919317_CR10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2307\/3578398","volume":"135","author":"L. E. Gerweck","year":"1993","unstructured":"Gerweck, L. E., Seneviratne, T., and Gerweck, K. K., Energy status and radiological hypoxia at specified oxygen concentrations. Radiat. Res.135 (1993) 69\u201374.","journal-title":"Radiat. Res."},{"key":"BF01919317_CR11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2307\/3577350","volume":"117","author":"L. E. Gerweck","year":"1989","unstructured":"Gerweck, L. E., Urano, M., Koutcher, J., Fellenz, M. P., and Kahn, J., Relationship between energy status, hypoxic cell fraction and hyperthermic sensitivity in a murine fibrosarcoma. Radiat. Res.117 (1989) 448\u2013458.","journal-title":"Radiat. Res."},{"key":"BF01919317_CR12","first-page":"6098","volume":"51","author":"M. Hoeckel","year":"1991","unstructured":"Hoeckel, M., Schlenger, K., Knoop, C., and Vaupel, P., Oxygenation of carcinomas of the uterine cervix: evaluation of computerized O2 tension measurements. Cancer Res.51 (1991) 6098\u20136102.","journal-title":"Cancer Res."},{"key":"BF01919317_CR13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2307\/3577782","volume":"121","author":"J. A. Koutcher","year":"1990","unstructured":"Koutcher, J. A., Alfieri, A. A., Barnett, D. C., Cowburn, D. C., Kornblith, A. B., and Kim, J. H., Changes in31P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors. Radiat. Res.121 (1990) 312\u2013319.","journal-title":"Radiat. Res."},{"key":"BF01919317_CR14","first-page":"1681","volume":"50","author":"W. Mueller-Klieser","year":"1990","unstructured":"Mueller-Klieser, W., Schaefer, C., Walenta, S., Rofstad, E. K., Fenton, B. M., and Sutherland, R. M., Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy and cryospectrophotometry. Cancer Res.50 (1990) 1681\u20131685.","journal-title":"Cancer Res."},{"key":"BF01919317_CR15","first-page":"271","volume":"49","author":"T. C. Ng","year":"1982","unstructured":"Ng, T. C., Evanochko, W. T., Hiramoto, R. N., Ghanta, V. K., Lilly, M. B., Lawson, A. J., Corbett, T. H., Durant, J. R., and Glickson, J. D.,31P NMR spectroscopy of in vivo tumors. J. Magnet. Reson.49 (1982) 271\u2013286.","journal-title":"J. Magnet. Reson."},{"key":"BF01919317_CR16","first-page":"267","volume":"20","author":"P. Okunieff","year":"1991","unstructured":"Okunieff, P., Singer, S., and Vaupel, P., Magnetization transfer31P-NMR to measure metabolic states, dynamic changes and enzyme kinetics. Funktionsanal. biolog. Systeme20 (1991) 267\u2013292.","journal-title":"Funktionsanal. biolog. Systeme"},{"key":"BF01919317_CR17","first-page":"89","volume":"48","author":"L. M. Rodrigues","year":"1988","unstructured":"Rodrigues, L. M., Midwood, C. J., Coombes, R. C., Stevens, A. N., Stubbs, M., and Griffiths, J. R.,31P nuclear magnetic resonance spectroscopy studies of the response of rat mammary tumors to endocrine therapy. Cancer Res.48 (1988) 89\u201393.","journal-title":"Cancer Res."},{"key":"BF01919317_CR18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0167-8140(88)90021-7","volume":"12","author":"E. K. Rofstad","year":"1988","unstructured":"Rofstad, E. K., De Muth, P., and Sutherland, R. M.,31P NMR spectroscopy measurements of human ovarian carcinoma xenografts: relationship to tumor volume, growth rate, necrotic fraction and differentiation status. Radiother. Oncol.12 (1988) 315\u2013326.","journal-title":"Radiother. Oncol."},{"key":"BF01919317_CR19","first-page":"5440","volume":"48","author":"E. K. Rofstad","year":"1988","unstructured":"Rofstad, E. K., De Muth, P., Fenton, B. M., and Sutherland, R. M.,31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracepillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res.48 (1988) 5440\u20135446.","journal-title":"Cancer Res."},{"key":"BF01919317_CR20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/09553008814552071","volume":"54","author":"E. K. Rofstad","year":"1988","unstructured":"Rofstad, E. K., Howell, R. L., De Muth, P., Ceckler, T. L., and Sutherland, R. M.,31P NMR spectroscopy in vivo of two murine tumor lines with widely different fractions of radiobiologically hypoxic cells. Int. J. Radiat. Biol.54 (1988) 635\u2013649.","journal-title":"Int. J. Radiat. Biol."},{"key":"BF01919317_CR21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/nbm.1940050606","volume":"5","author":"M. Stubbs","year":"1992","unstructured":"Stubbs, M., Bhujwalla, Z. M., Tozer, G. M. Rodrigues, L. M., Maxwell, R. J., Morgan, R., Howe, F. A., and Griffiths, J. R., An assessment of31P MRS as a method of measuring pH in rat tumors. NMR Biomed.5 (1992) 351\u2013359.","journal-title":"NMR Biomed."},{"key":"BF01919317_CR22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/bjc.1990.47","volume":"61","author":"M. Stubbs","year":"1990","unstructured":"Stubbs, M., Coombes, R. C., Griffiths, J. R., Maxwell, R. J., Rodrigues, L. M., and Gusterson, B. A.31P-NMR spectroscopy and histological studies of the response of rat mammary tumors to endocrine therapy. Br. J. Cancer61 (1990) 258\u2013262.","journal-title":"Br. J. Cancer"},{"key":"BF01919317_CR23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/bjc.1989.343","volume":"60","author":"M. Stubbs","year":"1989","unstructured":"Stubbs, M., Rodrigues, L. M., and Griffiths, J. R., Growth studies of subcutaneous rat tumors: comparison of31P-NMR spectroscopy, acid extracts and histology. Br. J. Cancer60 (1989) 701\u2013707.","journal-title":"Br. J. Cancer"},{"key":"BF01919317_CR24","first-page":"4373","volume":"49","author":"I. F. Tannock","year":"1989","unstructured":"Tannock, I. F., and Rotin, D., Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res.49 (1989) 4373\u20134384.","journal-title":"Cancer Res."},{"key":"BF01919317_CR25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2307\/3576953","volume":"109","author":"G. Tozer","year":"1987","unstructured":"Tozer, G., Suit, H. D., Barlai-Kovach, M., Brunengraber, H., and Biaglow, J., Energy metabolism and blood perfusion in a mouse mammary adenocarcinoma during growth and following X irradiation. Radiat. Res.109 (1987) 275\u2013293.","journal-title":"Radiat. Res."},{"key":"BF01919317_CR26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/nbm.1940050515","volume":"5","author":"G. M. Tozer","year":"1992","unstructured":"Tozer, G. M., and Griffiths, J. R., The contribution made by cell death and oxygenation to31P MRS observations of tumors energy metabolism. NMR Biomed.5 (1992) 279\u2013289.","journal-title":"NMR Biomed."},{"key":"BF01919317_CR27","first-page":"53","volume-title":"Drug Resistance in Oncology","author":"P. Vaupel","year":"1993","unstructured":"Vaupel, P., Oxygenation of solid tumors, in: Drug Resistance in Oncology, pp. 53\u201385. Ed. B. A. Teicher, Marcel Dekker, New York 1993."},{"key":"BF01919317_CR28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/nbm.1940050505","volume":"5","author":"P. Vaupel","year":"1992","unstructured":"Vaupel, P., Physiological properties of malignant tumors. NMR Biomed.5 (1992) 220\u2013225.","journal-title":"NMR Biomed."},{"key":"BF01919317_CR29","first-page":"6449","volume":"49","author":"P. Vaupel","year":"1989","unstructured":"Vaupel, P., Kallinowski, F., and Okunieff, P., Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res.49 (1989) 6449\u20136465.","journal-title":"Cancer Res."},{"key":"BF01919317_CR30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2307\/3577798","volume":"120","author":"P. Vaupel","year":"1989","unstructured":"Vaupel, P., Okunieff, P., Kallinowski, F., and Neuringer, L. J., Correlations between31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma. Radiat. Res.120 (1989) 477\u2013493.","journal-title":"Radiat. Res."},{"key":"BF01919317_CR31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/nbm.1940070305","volume":"7","author":"P. Vaupel","year":"1994","unstructured":"Vaupel, P., Schaefer, C., and Okunieff, P., Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia and high levels of lactate and total Pi. NMR Biomed.7 (1994) 128\u2013136.","journal-title":"NMR Biomed."},{"key":"BF01919317_CR32","first-page":"3316","volume":"51","author":"P. Vaupel","year":"1991","unstructured":"Vaupel, P., Schlenger, K., Knoop, C., and Hoeckel, M., Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res.51 (1991) 3316\u20133322.","journal-title":"Cancer Res."},{"key":"BF01919317_CR33","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/bjc.1992.417","volume":"66","author":"S. Walenta","year":"1992","unstructured":"Walenta, S., Dellian, M., Goetz, A. E., Kuhnle, G. E. H., and Mueller-Klieser, W., Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumors. Br. J. Cancer66 (1992) 1099\u20131102.","journal-title":"Br. J. Cancer"}],"container-title":["Experientia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01919317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01919317\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01919317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:38:56Z","timestamp":1557448736000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01919317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["BF01919317"],"URL":"https:\/\/doi.org\/10.1007\/bf01919317","relation":{},"ISSN":["0014-4754","1420-9071"],"issn-type":[{"value":"0014-4754","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}