{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:46:59Z","timestamp":1790110019330,"version":"4.0.1"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[1985,11,1]],"date-time":"1985-11-01T00:00:00Z","timestamp":499651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experientia"],"published-print":{"date-parts":[[1985,11]]},"DOI":"10.1007\/bf01949989","type":"journal-article","created":{"date-parts":[[2005,7,31]],"date-time":"2005-07-31T19:32:48Z","timestamp":1122838368000},"page":"1357-1361","source":"Crossref","is-referenced-by-count":34,"title":["Alkaline phosphatase isozymes in cultured human cancer cells"],"prefix":"10.1007","volume":"41","author":[{"given":"F.","family":"Herz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01949989_CR1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0006-3002(60)91497-9","volume":"45","author":"Z. Ahmed","year":"1960","unstructured":"Ahmed, Z., and King, E. J., Kinetics of placental alkaline phosphatase. Biochim. biophys. Acta45 (1960) 581\u2013592.","journal-title":"Biochim. biophys. Acta"},{"key":"BF01949989_CR2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1515\/znb-1958-0205","volume":"13b","author":"W. Albrecht","year":"1958","unstructured":"Albrecht, W., Mittelstrass, H. K., and Sauthoff, R., Das Verhalten der alkalischen und sauren Phosphatase in Zellkulturen aus Affennieren nach Infektion mit ECHO-Virus Serotyp 9 und Poliovirus hominis Type 1. Z. Naturforsch.13b (1958) 71\u201374.","journal-title":"Z. Naturforsch."},{"key":"BF01949989_CR3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-4827(59)90288-5","volume":"18","author":"J. G. Bachtold","year":"1959","unstructured":"Bachtold, J. G., Deig, F. E., and Gebhardt, L. P., Phosphatase activity in normal and poliovirus-infected tissue cultures. Exp. Cell Res.18 (1959) 29\u201344.","journal-title":"Exp. Cell Res."},{"key":"BF01949989_CR4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/bj2110553","volume":"211","author":"C. M. Behrens","year":"1983","unstructured":"Behrens, C. M., Enns, C. A., and Sussman, H. H., Characterization of human foetal intestinal alkaline phosphatase. Comparison with the isoenzymes from the adult intestine and human tumour cell lines. Biochem. J.211 (1983) 553\u2013558.","journal-title":"Biochem. J."},{"key":"BF01949989_CR5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/ijc.2910270510","volume":"27","author":"F. J. Benham","year":"1981","unstructured":"Benham, F. J., Fogh J., and Harris, H., Alkaline phosphatase expression in human cell lines derived from various malignancies. Int. J. Cancer27 (1981) 637\u2013644.","journal-title":"Int. J. Cancer"},{"key":"BF01949989_CR6","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1073\/pnas.76.8.4016","volume":"76","author":"F. J. Benham","year":"1979","unstructured":"Benham, F. J., and Harris, H., Human cell lines expressing intestinal alkaline phosphatase. Proc. natn. Acad. Sci. USA76 (1979) 4016\u20134019.","journal-title":"Proc. natn. Acad. Sci. USA"},{"key":"BF01949989_CR7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01546490","volume":"4","author":"F. J. Benham","year":"1978","unstructured":"Benham, F. J., Povey, M. S., and Harris, H., Heterogeneity of alkaline phosphatases in different HeLa cells. Som. Cell Genet.4 (1978) 13\u201325.","journal-title":"Som. Cell Genet."},{"key":"BF01949989_CR8","first-page":"347","volume":"153","author":"C. Bimes","year":"1959","unstructured":"Bimes, C., Planel, H., and David, J. F., Recherches histochimiques sur la souche canc\u00e9reuse HeLa. C. r. Soc. Biol.153 (1959) 347\u2013350.","journal-title":"C. r. Soc. Biol."},{"key":"BF01949989_CR9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0021-9258(18)74489-X","volume":"118","author":"O. Bodansky","year":"1937","unstructured":"Bodansky, O., Are the phosphatases of bone, kidney, intestine and serum identical? The use of bile acids in their differentiation. J. biol. Chem.118 (1937) 341\u2013362.","journal-title":"J. biol. Chem."},{"key":"BF01949989_CR10","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1126\/science.134.3484.1002","volume":"134","author":"S. H. Boyer","year":"1961","unstructured":"Boyer, S. H., Alkaline phosphatase in human sera and placentae. Science134 (1961) 1002\u20131004.","journal-title":"Science"},{"key":"BF01949989_CR11","first-page":"23","volume":"7","author":"M. Chevremont","year":"1949","unstructured":"Chevremont, M., and Firket, H., Phosphatase alcaline et croissance des cultures de tissus. J. Cyto-embryol. Belgo-N\u00e9erland.7 (1949) 23\u201326.","journal-title":"J. Cyto-embryol. Belgo-N\u00e9erland"},{"key":"BF01949989_CR12","first-page":"46","volume":"6","author":"R. Cloetens","year":"1939","unstructured":"Cloetens, R., Identification de deux phosphatases \u2018alcalines\u2019 dans les organes animaux. Enzymologia6 (1939) 46\u201356.","journal-title":"Enzymologia"},{"key":"BF01949989_CR13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/190085a0","volume":"190","author":"R. P. Cox","year":"1961","unstructured":"Cox, R. P., and MacLeod, C. M., Hormonal induction of alkaline phosphatase in human cells in tissue culture. Nature190 (1961) 85\u201387.","journal-title":"Nature"},{"key":"BF01949989_CR14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/28.5.6247391","volume":"28","author":"F. Dolbeare","year":"1980","unstructured":"Dolbeare, F., Vanderlaan, M., and Phares, W., Alkaline phosphatase and an acid arylamidase as marker enzymes for normal and transformed WI-38 cells. J. Histochem. Cytochem.28 (1980) 419\u2013426.","journal-title":"J. Histochem. Cytochem."},{"key":"BF01949989_CR15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00485476","volume":"3","author":"N. A. Elson","year":"1969","unstructured":"Elson, N. A., and Cox, R. P., Production of fetal-like alkaline phosphatase by HeLa cells. Biochem. Genet.3 (1969) 549\u2013561.","journal-title":"Biochem. Genet."},{"key":"BF01949989_CR16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1042\/bj0230767","volume":"23","author":"H. B. Fell","year":"1929","unstructured":"Fell, H. B., and Robison, R., The growth, development and phosphatase activity of embryonic avian femora and limb-buds cultivated in vitro. Biochem. J.23 (1929) 767\u2013784.","journal-title":"Biochem. J."},{"key":"BF01949989_CR17","first-page":"414","volume-title":"The Enzymes, vol. 4","author":"H. N. Fernley","year":"1971","unstructured":"Fernley, H. N., Mammalian alkaline phosphatases, in: The Enzymes, vol. 4, 3rd edn., pp. 414\u2013447. Ed. P. D. Boyer. Academic Press, New York 1971.","edition":"3rd edn."},{"key":"BF01949989_CR18","first-page":"2268","volume":"36","author":"L. Fishman","year":"1976","unstructured":"Fishman, L., Miyayama, H., Driscoll, S. G., and Fishman, W. H., Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer. Cancer Res.36 (1976) 2268\u20132273.","journal-title":"Cancer Res."},{"key":"BF01949989_CR19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/219697a0","volume":"219","author":"W. H. Fishman","year":"1968","unstructured":"Fishman, W. H., Inglis, N. R., Green, S., Anstiss, C.L., Gosh, N. K., Reif, A. E., Rustigian, R., Krant, M. J., and Stolbach, L. L., Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer. Nature219 (1968) 697\u2013699.","journal-title":"Nature"},{"key":"BF01949989_CR20","first-page":"150","volume":"28","author":"W. H. Fishman","year":"1968","unstructured":"Fishman, W. H., Inglis, N. R., Stolbach, L. L., and Krant, M. J., A serum alkaline phosphatase isoenzyme of human neoplastic cell origin. Cancer Res.28, (1968) 150\u2013154.","journal-title":"Cancer Res."},{"key":"BF01949989_CR21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1749-6632.1975.tb25423.x","volume":"259","author":"W. H. Fishman","year":"1975","unstructured":"Fishman, W. H., and Singer, R. M., Placental alkaline phosphatase. Regulation of expression in cancer cells. Ann. N.Y. Acad. Sci.259 (1975) 261\u2013272.","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"BF01949989_CR22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0014-4827(60)90296-2","volume":"21","author":"P. Fortelius","year":"1960","unstructured":"Fortelius, P., Saksela, E., and Sax\u00e9n, E., A HeLa cell clonal line lacking alkaline phosphatase activity. Exp. Cell Res.21 (1960) 616\u2013618.","journal-title":"Exp. Cell Res."},{"key":"BF01949989_CR23","first-page":"750","volume":"227","author":"S. M. Gartler","year":"1967","unstructured":"Gartler, S. M., Apparent HeLa cell contamination of human heteroploid cell lines. Nature227 (1967) 750\u2013751.","journal-title":"Nature"},{"key":"BF01949989_CR24","first-page":"264","volume":"12","author":"G. O. Gey","year":"1952","unstructured":"Gey, G. O., Coffman, W. D., and Kubicek, M. T., Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res.12 (1952) 264\u2013265.","journal-title":"Cancer Res."},{"key":"BF01949989_CR25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/BF00531588","volume":"63","author":"A. Gropp","year":"1959","unstructured":"Gropp, A., Vergleichende enzymhistochemische Beobachtungen zum Phosphatasenachweis und einigen Carcinomzellst\u00e4mmen in vitro sowie \u00fcber milieubedingte Ver\u00e4nderungen der Enzymaktivit\u00e4t. Z. Krebsforsch.63 (1959) 156\u2013167.","journal-title":"Z. Krebsforsch"},{"key":"BF01949989_CR26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0014-4827(58)90076-4","volume":"15","author":"A. Gropp","year":"1958","unstructured":"Gropp, A., Bontke, E., and Hupe, K., Untersuchungen zum Nachweis der alkalischen Phosphatase an in vitro gez\u00fcchteten menschlichen Carcinomzellen mit besonderer Ber\u00fccksichtigung ihrer Beziehung zu der Zelloberfl\u00e4che. Exp. Cell Res.15 (1958) 200\u2013213.","journal-title":"Exp. Cell Res."},{"key":"BF01949989_CR27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1073\/pnas.76.1.323","volume":"76","author":"T. A. Hamilton","year":"1979","unstructured":"Hamilton, T. A., Tin, A. W., and Sussman, H. H., Regulation of alkaline phosphatase expression in human choriocarcinoma cell lines. Proc. natn. Acad. Sci. USA76 (1979) 323\u2013327.","journal-title":"Proc. natn. Acad. Sci. USA"},{"key":"BF01949989_CR28","first-page":"95","volume":"76","author":"H. Harris","year":"1982","unstructured":"Harris, H., Multilocus enzyme systems and the evolution of gene expression: The alkaline phosphatases as a model example. Harvey Lect.76 (1982) 95\u2013124.","journal-title":"Harvey Lect."},{"key":"BF01949989_CR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0003-9861(73)90616-4","volume":"158","author":"F. Herz","year":"1973","unstructured":"Herz, F., Alkaline phosphatase in KB cells: Influence of hyperosmolality and prednisolone on enzyme activity and thermostability. Archs Biochem. Biophys.158 (1973) 225\u2013235.","journal-title":"Archs Biochem. Biophys."},{"key":"BF01949989_CR30","first-page":"139","volume-title":"Human Alkaline Phosphatases","author":"F. Herz","year":"1984","unstructured":"Herz, F., Induction of alkaline phosphatase expression in cultured cancer cells, in: Human Alkaline Phosphatases. pp. 139\u2013166. Eds T. Stigbrand and W. H. Fishman, Alan R. Liss, Inc. New York 1984."},{"key":"BF01949989_CR31","first-page":"1943","volume":"34","author":"F. Herz","year":"1974","unstructured":"Herz, F., Barlebo, H., and Koss, L. G., Modulation of alkaline phosphatase activity in cell cultures derived from human urinary bladder carcinoma. Cancer Res.34 (1974) 1943\u20131946.","journal-title":"Cancer Res."},{"key":"BF01949989_CR32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0167-4889(83)90083-6","volume":"762","author":"F. Herz","year":"1983","unstructured":"Herz, F., and Halwer, M., Preferential alkaline phosphatase isoenzyme induction by sodium butyrate. Biochim. biophys. Acta762 (1983) 289\u2013294.","journal-title":"Biochim. biophys. Acta"},{"key":"BF01949989_CR33","first-page":"3209","volume":"37","author":"F. Herz","year":"1977","unstructured":"Herz, F., Miller, O. J., Miller, D. A., Auersperg, N., and Koss, L. G., Chromosome analysis and alkaline phosphatase of C4I, a cell line of human cervical origin distinct from HeLa. Cancer Res.37 (1977) 3209\u20133213.","journal-title":"Cancer Res."},{"key":"BF01949989_CR34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0003-9861(62)90328-4","volume":"96","author":"F. Herz","year":"1962","unstructured":"Herz, F., and Nitowsky, H. M., Alkaline phosphatase activity of human cell cultures: Kinetic and physical-chemical properties. Archs Biochem. Biophys.96 (1962) 506\u2013515.","journal-title":"Archs Biochem. Biophys."},{"key":"BF01949989_CR35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0003-9861(81)90224-1","volume":"210","author":"F. Herz","year":"1981","unstructured":"Herz, F., Schermer, A., Halwer, M., and Bogart, L. H., Alkaline phosphatase in HT-29, a human colon cancer cell line: Influenceof sodium butyrate and hyperosmolality. Archs Biochem. Biophys.210 (1981) 581\u2013591.","journal-title":"Archs Biochem. Biophys."},{"key":"BF01949989_CR36","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/1831529b0","volume":"183","author":"T. Horiuchi","year":"1959","unstructured":"Horiuchi, T., Horiuchi, S., and Mizuno, D., A possible negative feedback phenomenon controlling formation of alkaline phosphomonoesterase inEscherichia coli. Nature183 (1959) 1529\u20131530.","journal-title":"Nature"},{"key":"BF01949989_CR37","first-page":"282","volume":"45","author":"R. Jemmerson","year":"1985","unstructured":"Jemmerson, R., Shah, N., Takeya, M., and Fishman, W. H., Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells. Cancer Res.45 (1985) 282\u2013287.","journal-title":"Cancer Res."},{"key":"BF01949989_CR38","first-page":"2025","volume":"35","author":"T. Kameya","year":"1975","unstructured":"Kameya, T., Kuramoto, H., Susuki, K., Kanjo, T., Oshikiri, T., Hayashi, H., and Itakura, M., A human gastric choriocarcinoma cell line with human gonadotropin and placental alkaline phosphatase production. Cancer Res.35 (1975) 2025\u20132032.","journal-title":"Cancer Res."},{"key":"BF01949989_CR39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0009-8981(78)90444-8","volume":"88","author":"G. Knaup","year":"1978","unstructured":"Knaup, G., Pfleiderer, G., and Bayreuther, K., Human diploid lung fibroblast cell lines WI26 and WI38 exhibit isozyme shift of alkaline phosphatase after viral transformation. Clinica chim. Acta88 (1978) 375\u2013383.","journal-title":"Clinica chim. Acta"},{"issue":"suppl. 8","key":"BF01949989_CR40","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1365-3083.1978.tb03978.x","volume":"8","author":"R. H. Kottel","year":"1978","unstructured":"Kottel, R. H., and Fishman, W. H., Modulation of HeLa alkaline phosphatase isoenzyme expression by prednisolone. Scand. J. Immun.8 (suppl. 8) (1978) 571\u2013574.","journal-title":"Scand. J. Immun."},{"key":"BF01949989_CR41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1042\/bj2000679","volume":"200","author":"R. H. Kottel","year":"1981","unstructured":"Kottel, R. H., and Fishman, W. H., Placental alkaline phosphatase isoenzyme expression by the non-HeLa DoT cervical-carcinoma cell line. Biochem. J.200 (1981) 679\u2013684.","journal-title":"Biochem. J."},{"key":"BF01949989_CR42","first-page":"93","volume-title":"Biochemical markers for Cancer","author":"R. H. Kottel","year":"1982","unstructured":"Kottel, R. H., and Fishman, W. H., Developmental alkaline phosphatases as biochemical tumor Markers, in: Biochemical markers for Cancer, pp. 93\u2013115, Ed. T. M. Chu, Marcel Dekker, Inc, New York 1982."},{"key":"BF01949989_CR43","first-page":"348","volume":"10","author":"E. Kov\u00e1cs","year":"1960","unstructured":"Kov\u00e1cs, E., Comparative biochemical studies on normal and on poliomyelitis virus infected tissue cultures. X. Enzyme changes in the host cells during arrested or abortive infection. Z. Vitam.-Horm.-Fermentforsch.10 (1960) 348\u2013360.","journal-title":"Z. Vitam.-Horm.-Fermentforsch."},{"key":"BF01949989_CR44","first-page":"665","volume-title":"Carcino-Embryonic Proteins: Chemistry, Biology, Clinical Application, vol. 2","author":"S. Kudo","year":"1979","unstructured":"Kudo, S., Seike, H., Higashino, K., Ohtani, R., Yamamura, Y., Takeuchi, T., and Hirohashi, S., Occurrence of Kasahara isoenzyme in an established cell line, CCL 6 from human fetal intestine, in: Carcino-Embryonic Proteins: Chemistry, Biology, Clinical Application, vol. 2, pp. 665\u2013672. Ed. F.-G. Lehmann, Elsevier\/North Holland, Amsterdam 1979."},{"key":"BF01949989_CR45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jcp.1040910112","volume":"91","author":"M. A. Ludue\u00f1a","year":"1977","unstructured":"Ludue\u00f1a, M. A., Iverson, G. M., and Sussman, H. H., Expression of liver and placental alkaline phosphatases in Chang liver cells. J. Cell Physiol.91 (1977) 119\u2013130.","journal-title":"J. Cell Physiol."},{"key":"BF01949989_CR46","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1016\/S0021-9258(17)33533-0","volume":"251","author":"M. A. Ludue\u00f1a","year":"1976","unstructured":"Ludue\u00f1a, M. A., and Sussman, H. H., Characterizationof KB alkaline phosphatase. Evidence of similiarity to placental alkaline phosphatase. J. biol. Chem.251 (1976) 2620\u20132628.","journal-title":"J. biol. Chem."},{"key":"BF01949989_CR47","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/jnci\/52.6.1705","volume":"52","author":"M. A. Ludue\u00f1a","year":"1974","unstructured":"Ludue\u00f1a, M. A., Sussman, H. H., and Rabson, A. S., Synthesis of human placental alkaline phosphatase in vitro by the ChaGo cell line. J. natn. Cancer Inst.52 (1974) 1705\u20131709.","journal-title":"J. natn. Cancer Inst."},{"key":"BF01949989_CR48","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4613-2970-1","volume-title":"Alkaline Phosphatase","author":"R. B. McComb","year":"1979","unstructured":"McComb, R. B., Bowers, Jr. G. N., and Posen, S., Alkaline Phosphatase. Plenum Press, New York 1979."},{"key":"BF01949989_CR49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1042\/bj1810067","volume":"181","author":"M. J. McKenna","year":"1979","unstructured":"McKenna, M. J., Hamilton, T. A., and Sussman, H. H., Comparison of human alkaline phosphatase isoenzymes: Structural evidence for three protein classes. Biochem. J.181 (1979) 67\u201373.","journal-title":"Biochem. J."},{"key":"BF01949989_CR50","first-page":"4540","volume":"42","author":"A. Morita","year":"1982","unstructured":"Morita, A., Tsao, D., and Kim, Y. S., Effect of sodium butyrate on alkaline phosphatase of HRT-18, a human rectal cancer cell line. Cancer Res.42, (1982) 4540\u20134545.","journal-title":"Cancer Res."},{"key":"BF01949989_CR51","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0006-291X(85)90623-0","volume":"126","author":"H. D. Mueller","year":"1985","unstructured":"Mueller, H. D., Leung, H., and Stinson, R. A., Different genes code for alkaline phosphatases from human fetal and adult intestine. Biochem. biophys. Res. Commun.126 (1985) 427\u2013433.","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF01949989_CR52","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1073\/pnas.75.8.3909","volume":"75","author":"R. A. Mulivor","year":"1978","unstructured":"Mulivor, R. A., Hanning, V. L., and Harris, H., Developmental changes in human intestinal alkaline phosphatase. Proc. natn. Acad. Sci. USA75 (1978) 3909\u20133912.","journal-title":"Proc. natn. Acad. Sci. USA"},{"key":"BF01949989_CR53","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1136\/jcp.18.3.359","volume":"18","author":"F. C. Neale","year":"1965","unstructured":"Neale, F. C., Clubb, J. S., Hotchkiss, D., and Posen, S., The heat stability of human placental alkaline phosphatase. J. clin. Path.18 (1965) 359\u2013363.","journal-title":"J. clin. Path."},{"key":"BF01949989_CR54","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1126\/science.6451928","volume":"212","author":"W. A. Nelson-Rees","year":"1981","unstructured":"Nelson-Rees, W. A., Daniels, D. W., and Flandermeyer, R. R., Cross-contamination of cells in culture. Science212 (1981) 446\u2013452.","journal-title":"Science"},{"key":"BF01949989_CR55","first-page":"447","volume":"64","author":"P. D. Neuwald","year":"1980","unstructured":"Neuwald, P. D., Anderson, C., Salivar, W. O., Aldenderfer, P. H., Dermody, W. C., Weintraub, B. D., Rosen, S. W., Nelson-Rees, W. A., and Ruddon, R. W., Expression of oncodevelopmental gene products by human tumor cells in culture. J. natn. Cancer Inst.64 (1980) 447\u2013459.","journal-title":"J. natn. Cancer Inst."},{"key":"BF01949989_CR56","first-page":"1682","volume":"41","author":"P. D. Neuwald","year":"1981","unstructured":"Neuwald, P. D., and Brooks, M., Altered form of placental alkaline phosphatase produced by JAR choriocarcinoma cells in culture. Cancer Res.41 (1981) 1682\u20131689.","journal-title":"Cancer Res."},{"key":"BF01949989_CR57","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/189756a0","volume":"189","author":"H. M. Nitowsky","year":"1961","unstructured":"Nitowsky, H. M., Herz, F., Alkaline phosphatase in cell cultures of human origin. Nature189 (1961) 756\u2013757.","journal-title":"Nature"},{"key":"BF01949989_CR58","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3181\/00379727-107-26678","volume":"107","author":"H. M. Nitowsky","year":"1961","unstructured":"Nitowsky, H. M., and Herz, F., Alkaline phosphatase activity of human cell cultures. Proc. Soc. exp. Biol. Med.107 (1961) 532\u2013534.","journal-title":"Proc. Soc. exp. Biol. Med."},{"key":"BF01949989_CR59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0006-291X(63)90554-0","volume":"11","author":"H. M. Nitowsky","year":"1963","unstructured":"Nitowsky, H. M., and Herz, F., Hormonal regulation of alkaline phosphatase in dispersed cell cultures. Biochem. biosphys. Res. Commun.11 (1963) 261\u2013266.","journal-title":"Biochem. biosphys. Res. Commun."},{"key":"BF01949989_CR60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0006-291X(63)90299-7","volume":"12","author":"H. M. Nitowsky","year":"1963","unstructured":"Nitowsky, H. M., Herz, F., and Geller, S., Induction of alkaline phosphatase in dispersed cell cultures by changes in osmolarity. Biochem. biophys. Res. Commun.12 (1963) 293\u2013299.","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF01949989_CR61","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ijc.2910320302","volume":"32","author":"S. Nozawa","year":"1983","unstructured":"Nozawa, S., Engvall, E., Kano, S., Kurihara, S., and Fishman, W. H., Sodium butyrate produces concordant expression of \u2018early placental\u2019 alkaline phosphatase, pregnancy-specific beta,-glycoprotein and human chorionic gonadotropin beta-subunit in a newly established uterine cervical cancer cell line (SKG-IIIa). Int. J. Cancer32 (1983) 267\u2013272.","journal-title":"Int. J. Cancer"},{"key":"BF01949989_CR62","first-page":"121","volume-title":"Pregnancy Proteins: Biology, Chemistry and Clinical Applications","author":"S. Nozawa","year":"1982","unstructured":"Nozawa, S., and Fishman, W. H., Heat-stable alkaline phosphatase: Chemistry and biology, in: Pregnancy Proteins: Biology, Chemistry and Clinical Applications, pp. 121\u2013153. Eds J. G. Grudzinskas, B. Teisner and M. Sepp\u00e4l\u00e4, Academic Press, Sydney 1982."},{"key":"BF01949989_CR63","first-page":"1748","volume":"43","author":"S. Nozawa","year":"1983","unstructured":"Nozawa, S., Udagawa, Y., Ohta, H., Kurihara, S., and Fishman, W. H., Newly established uterine cervical cancer cell line (SKG-III) with Regan isoenzyme, human chorionic gonadotropin\u03b2-subunit, and pregnancy-specific\u03b2 1-glycoprotein phenotypes. Cancer Res.43 (1983) 1748\u20131760.","journal-title":"Cancer Res."},{"key":"BF01949989_CR64","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0021-9258(17)37894-8","volume":"254","author":"T. Sakiyama","year":"1979","unstructured":"Sakiyama, T., Robinson, J. C. and Chou, J. Y., Characterization of alkaline phosphatase from human first trimester placentas. J. biol. Chem.254 (1979) 935\u2013938.","journal-title":"J. biol. Chem."},{"key":"BF01949989_CR65","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/281152a0","volume":"281","author":"L. E. Seargent","year":"1979","unstructured":"Seargent, L. E., and Stinson, R. A., Evidence that three structural genes code for human alkaline phosphatase. Nature281 (1979) 152\u2013154.","journal-title":"Nature"},{"key":"BF01949989_CR66","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.60.3.777","volume":"60","author":"R. M. Singer","year":"1974","unstructured":"Singer, R. M. and Fishman, W. H., Characterization of two HeLa sublines: TCRC-1 produces Regan isoenzyme and TCRC-2, non-Regan isoenzyme. J Cell Biol.60 (1974) 777\u2013780.","journal-title":"J Cell Biol."},{"key":"BF01949989_CR67","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/jnci\/60.3.573","volume":"60","author":"R. M. Singer","year":"1978","unstructured":"Singer, R. M., and Herz, F., Multiple effects of glucocorticoids and hyperosmolality on isoenzyme expression in cultured KB cells. J. natn. Cancer Inst.60, (1978) 573\u2013577.","journal-title":"J. natn. Cancer Inst."},{"key":"BF01949989_CR68","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jnci\/56.1.175","volume":"56","author":"R. M. Singer","year":"1976","unstructured":"Singer, R. M., Tompkins, W. A. F., White, L. J., and Perry, J. E., Co-production of Regan isoenzyme and carcinoembryonic antigen in HCT-8 cells. J. natn. Cancer Inst.56 (1976) 175\u2013178.","journal-title":"J. natn. Cancer Inst."},{"key":"BF01949989_CR69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-4827(77)90166-5","volume":"105","author":"K. V. Speeg Jr.","year":"1977","unstructured":"Speeg, K. V. Jr., Azizkhan, J. C., and Stromberg, K., Characteristics of alkaline phosphatase from two continuous lines of human choriocarcinoma cells. Exp. Cell Res.105 (1977) 199\u2013205.","journal-title":"Exp. Cell Res."},{"key":"BF01949989_CR70","first-page":"3","volume-title":"Human Alkaline Phosphatases","author":"T. Stigbrand","year":"1984","unstructured":"Stigbrand, T., Present status and future trends of human alkaline phosphatase, in: Human Alkaline Phosphatases, pp. 3\u201314. Eds. T. Stigbrand and W. H. Fishman. Alan R. Liss, Inc., New York 1984."},{"key":"BF01949989_CR71","first-page":"93","volume-title":"Isozymes, vol. 6","author":"T. Stigbrand","year":"1982","unstructured":"Stigbrand, T., Mill\u00e1n, J. L., and Fishman, W. H., The genetic basis of alkaline phosphatase isozyme expression, in: Isozymes, vol. 6, pp. 93\u2013111, Eds M. C. Rattazzi, J. G. Scandalios and G. S. Whitt. Alan R., Liss, Inc., New York 1982."},{"key":"BF01949989_CR72","first-page":"563","volume":"42","author":"N. Takahara","year":"1982","unstructured":"Takahara, N., Herz, F., Singer, R. M., Hirano, A., and Koss, L. G., Induction of alkaline phosphatase activity in cultured human intracranial tumor cells. Cancer Res.42 (1982) 563\u2013568.","journal-title":"Cancer Res."},{"key":"BF01949989_CR73","first-page":"4732","volume":"39","author":"S.-I. Tokumitsu","year":"1979","unstructured":"Tokumitsu, S.-I., Tokumitsu, K., Kohnoe, K., and Takeuchi, T., Characterization of liver-type alkaline phosphatase from human gastric carcinoma cells (KMK-2) in vitro. Cancer Res.39 (1979) 4732\u20134738.","journal-title":"Cancer Res."},{"key":"BF01949989_CR74","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0006-3002(60)91281-6","volume":"38","author":"A. Torriani","year":"1960","unstructured":"Torriani, A., Influence of inorganic phosphate on the formation of phosphatases byEscherichia coli. Biochim. biophys. Acta38 (1960) 460\u2013469.","journal-title":"Biochim. biophys. Acta"},{"key":"BF01949989_CR75","first-page":"205","volume":"85","author":"F. J. Vanneuville","year":"1977","unstructured":"Vanneuville, F. J., Leroy, J. G., and Van Elsen, A. F., Alkaline phosphatase: Further studies on its behaviour in human diploid fibroblasts. Archs int. Physiol. Biochim.85, (1977) 205\u2013206.","journal-title":"Archs int. Physiol. Biochim."},{"key":"BF01949989_CR76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0022-1759(82)90071-0","volume":"55","author":"L. Wray","year":"1982","unstructured":"Wray, L., and Harris, H., Demonstration using monoclonal antibodies of inter-locus heteromeric isozymes of human alkaline phosphatase. J. immun. Meth.55 (1982) 13\u201318.","journal-title":"J. immun. Meth."},{"key":"BF01949989_CR77","first-page":"758","volume":"43","author":"L. K. Wray","year":"1983","unstructured":"Wray, L. K., and Harris, H., Monoclonal antibodies to an ectopically expressed alkaline phosphatase in a human malignant cell line. Cancer Res.43 (1983) 758\u2013762.","journal-title":"Cancer Res."}],"container-title":["Experientia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01949989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01949989\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01949989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T10:59:33Z","timestamp":1626260373000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01949989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":77,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1985,11]]}},"alternative-id":["BF01949989"],"URL":"https:\/\/doi.org\/10.1007\/bf01949989","relation":{},"ISSN":["0014-4754","1420-9071"],"issn-type":[{"value":"0014-4754","type":"print"},{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}