{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:11:24Z","timestamp":1771625484783,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1980,11,1]],"date-time":"1980-11-01T00:00:00Z","timestamp":341884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agents and Actions"],"published-print":{"date-parts":[[1980,11]]},"DOI":"10.1007\/bf01968040","type":"journal-article","created":{"date-parts":[[2005,7,30]],"date-time":"2005-07-30T10:53:35Z","timestamp":1122720815000},"page":"422-426","source":"Crossref","is-referenced-by-count":46,"title":["Binding of [3H]cimetidine to rat brain tissue"],"prefix":"10.1007","volume":"10","author":[{"given":"Ian R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark T.","family":"Cleverley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Robin Ganellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Metters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01968040_CR1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/j.1471-4159.1973.tb06026.x","volume":"21","author":"M. Chasin","year":"1973","unstructured":"M. Chasin, F. Mamrak, S.G. Samaniego andS.M. Hess,Characteristics of the Catecholamine and Histamine Receptor sites Mediating Accumulation of Cyclic Adenosiee 3\u2032,5\u2032-Monophosphate in Guinea-Pig Brain, J. Neurochem.21, 1415 (1973).","journal-title":"J. Neurochem."},{"key":"BF01968040_CR2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1471-4159.1976.tb04452.x","volume":"26","author":"K. Dismukes","year":"1976","unstructured":"K. Dismukes, M. Rogers andJ.W. Daly,Cyclic Adenosine 3\u2032,5\u2032-Monophosphate Formation in Guinea-Pig Brain Slices: Effect of H 1 -and H 2 -Histaminergic Agonists, J. Neurochem.26, 785 (1976).","journal-title":"J. Neurochem."},{"key":"BF01968040_CR3","first-page":"971","volume":"14","author":"J.M. Palacios","year":"1978","unstructured":"J.M. Palacios, M. Garbarg, G. Barbin andJ.C. Schwartz,Pharmacological Characterization of Histamine Receptors Mediating the Stimulation of Cyclic AMP Accumulation in Slices from Guinea-Pig Hippocampus, Mol. Pharmacol.14, 971 (1978).","journal-title":"Mol. Pharmacol."},{"key":"BF01968040_CR4","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1073\/pnas.74.12.5697","volume":"74","author":"J.P. Green","year":"1977","unstructured":"J.P. Green, C.L. Johnson, H. Weinstein andS. Maayani,Antagonism of Histamine-Activated Adenylate Cyclase in Brain by D-Lysergic Acid Diethylamide, Proc. nat. Acad. Sci USA74, 5697 (1977).","journal-title":"Proc. nat. Acad. Sci USA"},{"key":"BF01968040_CR5","first-page":"87","volume":"209","author":"P.D. Kanof","year":"1979","unstructured":"P.D. Kanof andP. Greengard,Pharmacological Properties of Histamine-Sensitive Adenylate Cyclase from Mammalian Brain, J. Pharmac. exp. Ther.209, 87 (1979).","journal-title":"J. Pharmac. exp. Ther."},{"key":"BF01968040_CR6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0006-8993(77)90738-7","volume":"126","author":"S.R. Nahorski","year":"1977","unstructured":"S.R. Nahorski, K.J. Rogers andB.M. Smith,Stimulation of Cyclic Adenosine 3\u2032,5\u2032-monophosphate in Chick Cerebral Hemisphere Slices: Effects of H 1 and H 2 Histaminergic Agonists and Antagonists, Brain Res.126, 387 (1977).","journal-title":"Brain Res."},{"key":"BF01968040_CR7","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1471-4159.1978.tb00139.x","volume":"31","author":"S.J. Hill","year":"1978","unstructured":"S.J. Hill, P.C. Emson andJ.M. Young,The Binding of [ 3H]mepyramine to Histamine H 1 -Receptors in Guinea Pig Brain, J. Neurochem.31, 997 (1978).","journal-title":"J. Neurochem."},{"key":"BF01968040_CR8","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/j.1471-4159.1979.tb02276.x","volume":"32","author":"R.S.L. Chang","year":"1979","unstructured":"R.S.L. Chang, V.T. Tran andS.H. Snyder,Heterogeneity of Histamine H 1 -Receptors: Species Variations in [ 3 H]mepyramine Binding of Brain Membranes, J. Neurochem.32, 1653 (1979).","journal-title":"J. Neurochem."},{"key":"BF01968040_CR9","first-page":"6209","volume":"75","author":"V.T. Tran","year":"1978","unstructured":"V.T. Tran, R.S.L. Chang andS.H. Synder,Histamine H 1 -Receptors Identified in Mammalian Brain Membranes with [ 3 H]mepyramine, Proc. nat. Acad. Sci. USA75, 6209 (1978).","journal-title":"Proc. nat. Acad. Sci. USA"},{"key":"BF01968040_CR10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0006-8993(78)90498-5","volume":"149","author":"M. Rehavt","year":"1978","unstructured":"M. Rehavt andM. Sokolovsky,Multiple Binding Sites of Tricyclic Antidepressant Drugs to Mammalian Brain Receptors, Brain Res.149, 525 (1978).","journal-title":"Brain Res."},{"key":"BF01968040_CR11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0014-2999(78)90153-X","volume":"50","author":"W.P. Burkard","year":"1978","unstructured":"W.P. Burkard,Histamine H 2 -Receptor Binding with [ 3 H]metidine in Brain, Eur. J. Pharmac.50, 449 (1978).","journal-title":"Eur. J. Pharmac."},{"key":"BF01968040_CR12","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/0024-3205(80)90088-0","volume":"26","author":"D.A. Kendall","year":"1980","unstructured":"D.A. Kendall, J.W. Ferkany andS.J. Enna,Properties of [ 3 H]cimetidine Binding in Rat Brain Membrane Fractions, Life Sciences26, 1293 (1980).","journal-title":"Life Sciences"},{"key":"BF01968040_CR13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1042\/bj0800324","volume":"80","author":"G.N. Wilkinson","year":"1961","unstructured":"G.N. Wilkinson,Statistical Estimations in Enzyme Kinetics, Biochem. J.80, 324 (1961).","journal-title":"Biochem. J."},{"key":"BF01968040_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4157(76)90012-5","volume":"457","author":"R.J. Lefkowitz","year":"1976","unstructured":"R.J. Lefkowitz, L.E. Limbird, C. Mukherjee andM.G. Caron,The \u03b2-Adrenergic Receptor and Adenylate Cyclase, Biochim. Biophys. Acta457, 1 (1976).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF01968040_CR15","first-page":"266","volume":"21","author":"T.O. Yellin","year":"1979","unstructured":"T.O. Yellin, S.H. Buck, D.J. Gilman, D.F. Jones andJ.M. Wardleworth,ICI 125, 211: a Potent New Antisecretory Drug Acting on Histamine H 2 -Receptors, The Pharmacologist21, 266 (1979), Abstract 635.","journal-title":"The Pharmacologist"},{"key":"BF01968040_CR16","unstructured":"J. Bradshaw, R.T. Brittain, J.W. Clitherow, M.J. Daly, D. Jack, B.J. Price andR. Stables,Ranitidine (AH 19065): a New Potent, Selective Histamine H 2 -Receptor Antagonist, Br. J. Pharmac.66, 464P (1979)."},{"key":"BF01968040_CR17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/269163a0","volume":"269","author":"J.P. Green","year":"1977","unstructured":"J.P. Green andS. Maayani,Tricyclic Antidepressant Drugs Block Histamine H 2 -Receptor in Brain, Nature, Lond.269, 163 (1977).","journal-title":"Nature, Lond."},{"key":"BF01968040_CR18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/272329a0","volume":"272","author":"P.D. Kanof","year":"1978","unstructured":"P.D. Kanof andP. Greengard,Brain Histamine Receptors as Targets for Antidepressant Drugs, Nature, Lond.,272, 329 (1978).","journal-title":"Nature, Lond."},{"key":"BF01968040_CR19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01964878","volume":"7","author":"M.E. Parsons","year":"1977","unstructured":"M.E. Parsons, D.A.A. Owen, C.R. Ganellin andG.J. Durant,Dimaprit-[S-]3(N,N-dimethylamino)-propylisothiourea] \u2014 A Highly Specific Histamine H 2 -Receptor Agonist,Agents and Actions7, 31 (1977).","journal-title":"Agents and Actions"},{"key":"BF01968040_CR20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/276403a0","volume":"276","author":"G.J. Durant","year":"1978","unstructured":"G.J. Durant, W.A.M. Duncan, C.R. Ganellin, M.E. Parsons, R.C. Blakemore andA.C. Rasmussen,Impromidine (SK&F 92676) is a very Potent and Specific Agonist for Histamine H 2 -Receptors, Nature, Lond.276, 403 (1978).","journal-title":"Nature, Lond."},{"key":"BF01968040_CR21","first-page":"265","volume":"21","author":"S.T. Nielsen","year":"1979","unstructured":"S.T. Nielsen, T.O. Yellin, P.N. Edwards andM.S. Large,Radioligand Binding Assay of H 2 -Receptors with [ 3 H]ICIA 5165, The Pharmacologist21, 265 (1979), Abstract 634.","journal-title":"The Pharmacologist"},{"key":"BF01968040_CR22","first-page":"183","volume":"28","author":"C.R. Ganellin","year":"1978","unstructured":"C.R. Ganellin,Selectivity and the Design of Histamine H 2 -Receptor Antagonists, J. appl. Chem. Biotechnol.28, 183 (1978).","journal-title":"J. appl. Chem. Biotechnol."}],"container-title":["Agents and Actions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01968040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01968040\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01968040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T18:00:48Z","timestamp":1557770448000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01968040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["BF01968040"],"URL":"https:\/\/doi.org\/10.1007\/bf01968040","relation":{},"ISSN":["0065-4299","1420-908X"],"issn-type":[{"value":"0065-4299","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}