{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T19:17:52Z","timestamp":1649186272316},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agents and Actions"],"published-print":{"date-parts":[[1993,1]]},"DOI":"10.1007\/bf01976207","type":"journal-article","created":{"date-parts":[[2005,7,31]],"date-time":"2005-07-31T15:54:39Z","timestamp":1122825279000},"page":"165-170","source":"Crossref","is-referenced-by-count":1,"title":["Mucolytic activity of azelastine in mice and rats"],"prefix":"10.1007","volume":"38","author":[{"given":"N.","family":"Chand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Diamantis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Sofia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01976207_CR1","first-page":"S75","volume":"10","author":"J. L. Perhach","year":"1989","unstructured":"J. L. Perhach, J. J. Freitag and A. Rosenberg,Azelastine: A review in light of current concepts and therapies. J. Respir. Dis.10, S75-S85 (1989).","journal-title":"J. Respir. Dis."},{"key":"BF01976207_CR2","first-page":"S86","volume":"10","author":"J. P. Kemp","year":"1989","unstructured":"J. P. Kemp,Clinical and therapeutic experiences with azelastine. J. Respir. Dis.10, S86-S90 (1989).","journal-title":"J. Respir. Dis."},{"key":"BF01976207_CR3","first-page":"1225","volume":"40","author":"E. Ulbrich","year":"1990","unstructured":"E. Ulbrich and H. Nowak,Long-term multicentric study with azelastine in patients with intrinsic asthma.Arzneim. Forsch.40, 1225\u20131230 (1990).","journal-title":"Arzneim. Forsch."},{"key":"BF01976207_CR4","first-page":"1429","volume":"6","author":"S. Katayama","year":"1986","unstructured":"S. Katayama, N. Hashida and H. Shionoya,Induction of experimental asthma in rats sensitized by mouse IgE and inhibitory effect of azelastine. Prog. Med.6, 1429\u20131434 (1986).","journal-title":"Prog. Med."},{"key":"BF01976207_CR5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1398-9995.1993.tb02170.x","volume":"48","author":"N. Chand","year":"1993","unstructured":"N. Chand, V. E. Adusumalli, K. Nolan, W. Diamantis, J. K. Wichmann, J. Pivonka, C. N. Langevin, K. K. Wong, N. Kucharczyk and R. D. Sofia,Pharmacodynamic and pharmacokinetic studies with azelastine in the guinea pig: evidence for preferential distribution into the lung.Allergy (1993); 48: 19\u201324.","journal-title":"Allergy"},{"key":"BF01976207_CR6","first-page":"151","volume":"64","author":"N. Chand","year":"1990","unstructured":"N. Chand, K. Nolan, R. D. Sofia and W. Diamantis,Changes in aeroallergen-induced pulmonary mechanics in actively sensitized guinea pig: Inhibition by azelastine. Ann. Allergy64, 151\u2013154 (1990).","journal-title":"Ann. Allergy"},{"key":"BF01976207_CR7","first-page":"344","volume":"58","author":"N. Chand","year":"1987","unstructured":"N. Chand, K. Nolan, W. Diamantis and R. D. Sofia,Inhibition of acute lung anaphylaxis by aerosolized azelastine in guinea pigs sensitized by three different procedures. Ann. Allergy58, 344\u2013349 (1987).","journal-title":"Ann. Allergy"},{"key":"BF01976207_CR8","first-page":"A1068","volume":"6","author":"S. Ali","year":"1992","unstructured":"S. Ali, S. J. Mustafa and W. J. Metzger,Inhibition of allergen-induced airway hyperresponsiveness by azelastine in allergic rabbits: Dissociation from its anti-histamine H 1 activity. Fed. Proc.6, A1068 (1992).","journal-title":"Fed. Proc."},{"key":"BF01976207_CR9","first-page":"A198","volume":"85","author":"E. A. Meill","year":"1990","unstructured":"E. A. Meill, D. Denmead, P. Graf, W. M. Gold and O. L. Frick,Azelastine aerosol attenuates late-phase bronchial hyperresponsiveness in atopic dogs. J. Allergy Clin. Immunol.85, A198 (1990).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BF01976207_CR10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000236124","volume":"97","author":"N. Chand","year":"1992","unstructured":"N. Chand, K. Nolan, W. Diamantis and R. D. Sofia,inhibition of aeroallergen-induced bronchial eosinophilia by azelastine in guinea pigs. Int. Arch. Allergy Immunol.97, 229\u2013232 (1992).","journal-title":"Int. Arch. Allergy Immunol."},{"key":"BF01976207_CR11","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1378\/chest.99.5.1274","volume":"99","author":"J. Shindoh","year":"1991","unstructured":"J. Shindoh, S. Sugiyama, K. Takagi, T. Satake and T. Ozawa.Recovery time course of airway hyperresponsiveness to acetylcholine after ovalbumin challenge in guinea pigs. Chest99, 1274\u20131279 (1991).","journal-title":"Chest"},{"key":"BF01976207_CR12","first-page":"243","volume":"32","author":"U. Werner","year":"1991","unstructured":"U. Werner, J. Schmidt and I. Szelenyi,Influence of azelastine on IL-1 \u03b2 generation in vitro and IL-1 \u03b2 induced effect in vivo. Agents and Actions32, 243\u2013247 (1991).","journal-title":"Agents and Actions"},{"key":"BF01976207_CR13","first-page":"1509","volume":"39","author":"I. Todoroki","year":"1990","unstructured":"I. Todoroki I. Yoshizawa, Y. Kawano and T. Noma,Suppressive effect of azelastine on the induction of Df antigen specific IL-2 responsiveness in lymphocytes from patients with bronchial asthma. Jap. J. Allergol.39, 1509\u20131514 (1990).","journal-title":"Jap. J. Allergol."},{"key":"BF01976207_CR14","first-page":"44","volume":"11","author":"Y. Ikami","year":"1991","unstructured":"Y. Ikami, N. Kondo and T. Orii,Effect of azelastine on bronchial asthma complicated by atopic dermatitis. In vivo and in vitro study. Allergy Pract.11, 44\u201346 (1991).","journal-title":"Allergy Pract."},{"key":"BF01976207_CR15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF01983310","volume":"32","author":"I. Paegelow","year":"1991","unstructured":"I. Paegelow, H. Werner and I. Szelenyi,The effect of azelastine on an acute non-specific inflammation in comparison to the effect of dexamethasone. Agents and Actions32, 56\u201358 (1991).","journal-title":"Agents and Actions"},{"key":"BF01976207_CR16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-2999(91)90522-R","volume":"197","author":"M. C. R. Lima","year":"1991","unstructured":"M. C. R. Lima, M. A. Martins, S. A. C. Perez, P. M. R. Silva, R. S. B. Cordeiro and B. B. Vargaftig,Effect of azelastine on platelet-activating factor and antigen-induced pleurisy in rats. Eur. J. Pharmacol.197, 201\u2013207 (1991).","journal-title":"Eur. J. Pharmacol."},{"key":"BF01976207_CR17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0091-6749(87)90064-9","volume":"80","author":"L. M. Reid","year":"1987","unstructured":"L. M. Reid,The presence or absence of bronchial mucus in fatal asthma. J. Allergy Clin. Immunol.80, 415\u2013416 (1987).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BF01976207_CR18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0002-9343(71)90338-X","volume":"50","author":"H. Yeager Jr.","year":"1971","unstructured":"H. Yeager, Jr.,Tracheobronchial secretions. Am. J. Med.50, 493\u2013508 (1971).","journal-title":"Am. J. Med."},{"key":"BF01976207_CR19","first-page":"70","volume":"26","author":"U. Aceterrath-Tuckermann","year":"1989","unstructured":"U. Aceterrath-Tuckermann, C. Motta and I. Szelenyi,Effect of azelastine on microviscosity of bronchial lavage fluid obtained free actively sensitized and challenged guinea pigs. Agents and Actions26, 70\u201372 (1989).","journal-title":"Agents and Actions"},{"key":"BF01976207_CR20","first-page":"A288","volume":"85","author":"O. Ramirez","year":"1990","unstructured":"O. Ramirez, J. G. Zayas, E. M. App, B. K. Rubin and M. King,Tracheal mucus rheology and clearability in a canine model of asthma: Effect of azelastine. J. Allergy Clin. Immunol.85, A288 (1990).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BF01976207_CR21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0160-5402(84)90033-0","volume":"11","author":"H. Engler","year":"1984","unstructured":"H. Engler and I. Szelenyi,Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds. J. Pharmacol. Methods11, 151\u2013157 (1984).","journal-title":"J. Pharmacol. Methods"},{"key":"BF01976207_CR22","first-page":"167","volume":"36","author":"G. Graziani","year":"1980","unstructured":"G. Graziani and P. A. Cazzulani,Particularly useful method for studying expectorant activity in small animals. II Farmaco Ed. Pr.36, 167\u2013172 (1980).","journal-title":"II Farmaco Ed. Pr."},{"key":"BF01976207_CR23","first-page":"1281","volume":"33","author":"K. Kogi","year":"1983","unstructured":"K. Kogi, K. Kanishi and T. Saito,Pharmacological and toxicological studies on domiodol, a new mucolytic agent and expectorant. Arzneim-Forsch33, 1281\u20131286 (1983).","journal-title":"Arzneim-Forsch"},{"key":"BF01976207_CR24","first-page":"918","volume":"36","author":"R. Moratalla","year":"1986","unstructured":"R. Moratalla, R. Romera and A. Galiano,Pharmacological study of the new mucolytic drug N-guanyl-cysteine. Arzneim-Forsch.36, 918\u2013923 (1986).","journal-title":"Arzneim-Forsch."},{"key":"BF01976207_CR25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0192-0561(85)90045-1","volume":"7","author":"N. Chand","year":"1985","unstructured":"N. Chand, J. E. Harrison, S. M. Rooney, R. D. Sofia and W. Diamantis,Inhibition of passive cutaneous anaphylaxis (PCA) by azelastine: Dissociation of its antiallergic activities from antihistaminic and antiserotonin properties. Int. J. Immunopharmacol.7, 833\u2013838, (1985).","journal-title":"Int. J. Immunopharmacol."},{"key":"BF01976207_CR26","first-page":"178","volume":"83","author":"M. E. Bates","year":"1989","unstructured":"M. E. Bates and W. W. Busse,A comparison of azelastine regulation of leukocyte superoxide generation to other antiallergic compounds. J. Allergy Clin. Immunol.83, 178 (1989).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BF01976207_CR27","unstructured":"U. Achterrath-Tuckermann, E. Minker, V. Saano, J. Roux, F. Stroman and I. Szelenyi,Azelastine Influence on tracheobronchial mucus quality and mucociliary clearance. Poster: Eur. Acad, Allergy Clin. Immunol XV Paris, France, May 10\u201315, 1992, #597."},{"key":"BF01976207_CR28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000235002","volume":"90","author":"N. Chand","year":"1989","unstructured":"N. Chand, J. Pillar, K. Nolan, W. Diamantis and R. D. Sofia,Inhibition of allergic and nonallergic leukotriene C 4 formation and histamine secretion by azelastine: Implication for its mechanism of action. Int. Arch. Allergy Appl. Immunol.90, 67\u201370 (1989).","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"BF01976207_CR29","first-page":"117","volume":"26","author":"K. Takada","year":"1989","unstructured":"K. Takada and K. Takahashi,Clinical effect of azelastine on chronic cough. Med. Consult. New Rem.26, 117\u2013121 (1989).","journal-title":"Med. Consult. New Rem."}],"container-title":["Agents and Actions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01976207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01976207\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01976207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T18:31:06Z","timestamp":1557772266000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01976207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["BF01976207"],"URL":"https:\/\/doi.org\/10.1007\/bf01976207","relation":{},"ISSN":["0065-4299","1420-908X"],"issn-type":[{"value":"0065-4299","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}