{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:39:58Z","timestamp":1790692798373,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agents and Actions"],"published-print":{"date-parts":[[1994,10]]},"DOI":"10.1007\/bf01983477","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T22:05:18Z","timestamp":1123106718000},"page":"123-127","source":"Crossref","is-referenced-by-count":26,"title":["Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats"],"prefix":"10.1007","volume":"42","author":[{"given":"Michael W.","family":"Whitehouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Fairlie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. H.","family":"Thong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01983477_CR1","volume-title":"The Chemistry and Biology of Isoquinoline Alkaloids","year":"1985","unstructured":"J. D. Phillipson, M. F. Roberts and M. H. Zenk (Eds.The Chemistry and Biology of Isoquinoline Alkaloids. Springer, Berlin, 1985."},{"key":"BF01983477_CR2","first-page":"1","volume-title":"The Alkaloids","author":"K. T. Buck","year":"1987","unstructured":"K. T. Buck,The Benzylisoquinoline Alkaloids inThe Alkaloids, Academic Press, New York30, pp. 1\u2013222 (1987)."},{"key":"BF01983477_CR3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0192-0561(89)90086-6","volume":"11","author":"S. Y. Li","year":"1989","unstructured":"S. Y. Li, L. H. Ling, B. S. Teh, W. K. Seow and Y. H. Thong,Antiinflammatory and immunosuppressive properties of bisbenzylisoquinolines. Int. J. Immunopharm.11, 395\u2013401 (1989).","journal-title":"Int. J. Immunopharm."},{"key":"BF01983477_CR4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1159\/000234542","volume":"85","author":"W. K. Seow","year":"1988","unstructured":"W. K. Seow, A. Ferrante, D. B. H. Goh, A. H. Chalmers, S. Y. Li and Y. H. Thong,In vitro immunosuppressive properties of the plant alkaloid tetrandrine. Int. Archs. Allergy Appl. Immunol.85, 404\u2013409 (1988).","journal-title":"Int. Archs. Allergy Appl. Immunol."},{"key":"BF01983477_CR5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000234543","volume":"85","author":"W. K. Seow","year":"1988","unstructured":"W. K. Seow, A. Ferrante S. Y. Li, Y. H. Thong,Anti-phagocytic and anti-oxidant properties of the plant alkaloid tetrandrine. Int. Archs. Allergy Appl. Immunol.85, 410\u2013415 (1988).","journal-title":"Int. Archs. Allergy Appl. Immunol."},{"key":"BF01983477_CR6","first-page":"20","volume":"86","author":"B. S. Teh","year":"1988","unstructured":"B. S. Teh, W. K. Seow, A. H. Chalmers, B. Ioannoni and Y. H. ThongInhibition of histamine release from rat mast cells by the plant alkaloid tetrandrine. Int. Archs. Allergy Appl. Immunol.86, 20\u2013224 (1988).","journal-title":"Int. Archs. Allergy Appl. Immunol."},{"key":"BF01983477_CR7","first-page":"47","volume":"75","author":"W. K. Seow","year":"1989","unstructured":"W. K. Seow, A. Ferrante, S. Y. Li and Y. H. Thong,Suppression of human monocyte interleukin-1 production by the plant alkaloid tetrandrine. Clin. Exp. Immunol.75, 47\u201351 (1989).","journal-title":"Clin. Exp. Immunol."},{"key":"BF01983477_CR8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF01991238","volume":"36","author":"C. W. Wong","year":"1992","unstructured":"C. W. Wong, W. K. Seow, J. W. O'Callaghan and T. Y. Thong,Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor, Agents and Actions36, 112\u2013118 (1992).","journal-title":"Agents and Actions"},{"key":"BF01983477_CR9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1155\/S0962935193000262","volume":"2","author":"W. K. Seow","year":"1993","unstructured":"W. K. Seow, K. Nakamura, Y. Sugimura, Y. Sugimoto, Y. Yamada, D. P. Fairlie and Y. H. Thong,Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha. Mediators Inflammation2, 199\u2013203 (1993).","journal-title":"Mediators Inflammation"},{"key":"BF01983477_CR10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2249.1990.tb05239.x","volume":"80","author":"A. Ferrante","year":"1990","unstructured":"A. Ferrante, W. K. Seow, B. Rowan-Kelly and Y. H. Thong,Tetradrine, a plant alkaloid, inhibits the production of tumour necrosis factor alpha (cachectin) by human monocytes. Clin. Exp. Immunol.80, 232\u2013235 (1990).","journal-title":"Clin. Exp. Immunol."},{"key":"BF01983477_CR11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000234805","volume":"88","author":"B. S. Teh","year":"1989","unstructured":"B. S. Teh, B. Ioannoni, W. K. Seow, J. G. McCormack and Y. H. Thong,Suppression by tetrandrine of human platelet aggregation induced by platelet-activating factor (PAF) and other stimulants. Int. Archs. Allergy Appl. Immunol.88, 267\u2013272 (1989).","journal-title":"Int. Archs. Allergy Appl. Immunol."},{"key":"BF01983477_CR12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-2478(86)90131-8","volume":"13","author":"W. K. Seow","year":"1986","unstructured":"W. K. Seow, S. Y. Li and Y. H. Thong,Inhibitory effects of tetrandrine on human neutrophil and monocyte adherence. Immunol. Lett.13, 83\u201388 (1986).","journal-title":"Immunol. Lett."},{"key":"BF01983477_CR13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0192-0561(90)90088-5","volume":"12","author":"B. S. Teh","year":"1990","unstructured":"B. S. Teh, W. K. Seow, S. Y. Li and Y. H. Thong,Inhibition of prostaglandin and leukotriene production by the plant alkaooids tetrandrine and berbamine. Int. J. Immunopharmac.12, 321\u2013326 (1990).","journal-title":"Int. J. Immunopharmac."},{"key":"BF01983477_CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000236092","volume":"97","author":"C. W. Wong","year":"1992","unstructured":"C. W. Wong, W. K. Seow and Y. H. Thong,Comparative effects of tetrandrine and berbamine on acute and relapsing experimental allergic encephalitis in Lewis rats. Int. Archs. Allergy Appl. Immunol.97, 31\u201336 (1992).","journal-title":"Int. Archs. Allergy Appl. Immunol."},{"key":"BF01983477_CR15","first-page":"321","volume":"4","author":"Q. Li","year":"1981","unstructured":"Q. Li, Y. Xu, Z. Zhou, X. Chen, X. Huang, S. Chen, and C. Zhan,The therapeutic effect of tetrandrine on silicosis. Chin. J. Tuberc. Resp. Dis.4, 321\u2013328 (1981).","journal-title":"Chin. J. Tuberc. Resp. Dis."},{"key":"BF01983477_CR16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000235019","volume":"90","author":"S. Y. Li","year":"1989","unstructured":"S. Y. Li, B. S. Teh, W. K. Seow, L. H. Ling and Y. H. Thong,Effect of tetrandrine on immunological responses and cardiac transplant rejection in mice. Int. Archs. Allergy Appl. Immunol.90, 169\u2013173 (1989).","journal-title":"Int. Archs. Allergy Appl. Immunol."},{"key":"BF01983477_CR17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0192-0561(93)90094-F","volume":"15","author":"C. W. Wong","year":"1993","unstructured":"C. W. Wong, Y. H. Thong and W. K. Seow,Comparative effects of tetrandrine and berbamine on guineapig airway microvascular leakage induced by PAF and other allergic mediators. Int. J. Immunopharmac.15, 185\u2013193 (1993).","journal-title":"Int. J. Immunopharmac."},{"key":"BF01983477_CR18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/diab.41.5.616","volume":"41","author":"I. Lieberman","year":"1992","unstructured":"I. Lieberman, D. P. Lentz, G. A. Trucco, W. K. Seow and Y. H. Thong,Prevention by tetrandrine of spontaneous development of diabetes mellitus in BB rats. Diabetes41, 616\u2013619 (1992).","journal-title":"Diabetes"},{"key":"BF01983477_CR19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-3-642-66891-3_3","volume-title":"Anti-inflammatory Drugs","author":"C. G. Arman van","year":"1979","unstructured":"C. G. van Arman,Odemema and increased vascular permeability. InAnti-inflammatory Drugs (Eds. J. R. Vane and S. H. Ferreira) pp. 75\u201391. Springer, Berlin, 1979."},{"key":"BF01983477_CR20","doi-asserted-by":"crossref","unstructured":"M. E. J. Billingham and G. E. Davies,Experimental models of arthritis in animals as screening tests for drugs to treat arthritis in man. In Anti-inflammatory Drugs. (eds. J. R. Vane and S. H. Ferreira) Springer, Berlin, pp. 108\u2013113.","DOI":"10.1007\/978-3-642-66891-3_5"},{"key":"BF01983477_CR21","volume-title":"Statistical Methods","author":"G. W. Snedecor","year":"1989","unstructured":"G. W. Snedecor and W. G. Cochran,Statistical Methods, 8th Edition. Iowa State University Press, Ames, Iowa, 1989.","edition":"8th Edition"},{"key":"BF01983477_CR22","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.2042-7158.1992.tb03650.x","volume":"44","author":"K. D. Rainsford","year":"1992","unstructured":"K. D. Rainsford and M. W. Whitehouse,Anti-ulcer activity of a slow release zinc complex. J. Pharm. Pharmacol.44, 476\u2013482 (1992).","journal-title":"J. Pharm. Pharmacol."},{"key":"BF01983477_CR23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02735462","volume":"1","author":"M. W. Whitehouse","year":"1991","unstructured":"M. W. Whitehouse and B. Vernon-Roberts,Conditional pharmacology: Expression of anti-inflammatory activity may require pre-existent inflammatory mediators and\/or hormones. Inflammopharmacology1, 61\u201368 (1991).","journal-title":"Inflammopharmacology"},{"key":"BF01983477_CR24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02003221","volume":"31","author":"M. W. Whitehouse","year":"1990","unstructured":"M. W. Whitehouse, K. D. Rainsford, R. M. Taylor and B. Vernon-Roberts,Zine monoglycerolate: A slow release source of zinc with anti-arthritic activity. Agents and Actions31, 47\u201358 (1990).","journal-title":"Agents and Actions"}],"container-title":["Agents and Actions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01983477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01983477\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01983477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T21:26:25Z","timestamp":1557782785000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01983477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":24,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["BF01983477"],"URL":"https:\/\/doi.org\/10.1007\/bf01983477","relation":{},"ISSN":["0065-4299","1420-908X"],"issn-type":[{"value":"0065-4299","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}