{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:29:27Z","timestamp":1793752167132,"version":"4.6.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agents and Actions"],"published-print":{"date-parts":[[1992,5]]},"DOI":"10.1007\/bf01991240","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T05:58:21Z","timestamp":1123221501000},"page":"127-135","source":"Crossref","is-referenced-by-count":1,"title":["RP 54745, a potential antirheumatic compound. II.In vivo properties in different animal models"],"prefix":"10.1007","volume":"36","author":[{"given":"F.","family":"Folliard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Terlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01991240_CR1","unstructured":"F. Folliard, A. Bousseau and B. Terlain,RP 54745, a potential anti-rheumatic compound I. Inhibitor of macrophage stimulation and interleukin 1 production. Agents and Actions (submitted)."},{"key":"BF01991240_CR2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01969105","volume":"25","author":"F. Folliard","year":"1988","unstructured":"F. Folliard and B. Terlain,A novel method for the sampling of synovial fluid in mice. Assay of a synovial lysosomal enzyme in zymosan-induced arthritis. Agents and Actions25, 139\u2013145 (1988).","journal-title":"Agents and Actions"},{"key":"BF01991240_CR3","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/art.1780200714","volume":"20","author":"E. C. Keystone","year":"1977","unstructured":"E. C. Keystone, H. U. Schorlemmer, C. Pope and A. C. Allison,Zymosan-induced arthritis. A model of chronic proliferative arthritis following activation of the alternative pathway of complement. Arth. Rheum.20, 1396\u20131401 (1977).","journal-title":"Arth. Rheum."},{"key":"BF01991240_CR4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/art.1780200314","volume":"20","author":"D. Brackertz","year":"1977","unstructured":"D. Brackertz, G. F. Mitchell and I. R. Mackay,Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arth. Rheum.20, 841\u2013850 (1977).","journal-title":"Arth. Rheum."},{"key":"BF01991240_CR5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0162-3109(84)90022-5","volume":"8","author":"T. Stim","year":"1984","unstructured":"T. Stim, F. J. Persico and T. A. Garrabrant,Erythrocyte sedimentation rate quantitation in MRL\/lpr mice. Immunopharmacology8, 171\u2013174 (1984).","journal-title":"Immunopharmacology"},{"key":"BF01991240_CR6","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.4049\/jimmunol.140.7.2260","volume":"140","author":"R. Mortensen","year":"1988","unstructured":"R. Mortensen, J. Shapiro, B. F. Lin, S. Douches and R. Neta,Interaction of recombinant IL-1 and recombinant TNF in the induction of mouse acute phase proteins. J. Immunol.140, 2260\u20132266 (1988).","journal-title":"J. Immunol."},{"key":"BF01991240_CR7","first-page":"425","volume":"26","author":"S. Izui","year":"1976","unstructured":"S. Izui et al.,Determination of anti-DNA antibodies by a modified 125 I-labelled DNA binding test. Elimination of non-specific binding of DNA to non-immunoglobulin basic proteins by using an anionic detergent. Clin. Exp. Immunol.26, 425 (1976).","journal-title":"Clin. Exp. Immunol."},{"key":"BF01991240_CR8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.116.3.381","volume":"116","author":"G. B. Mackaness","year":"1962","unstructured":"G. B. Mackaness,Cellular resistance to infection. J. Exp. Med.116, 381 (1962).","journal-title":"J. Exp. Med."},{"key":"BF01991240_CR9","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1084\/jem.155.6.1690","volume":"115","author":"L. Hang","year":"1982","unstructured":"L. Hang, A. N. Theofilopoulos and F. Dixon,A spontaneous rheumatoid arthritis like disease in MRL\/lpr mice. J. Exp. Med.115, 1690\u20131701 (1982).","journal-title":"J. Exp. Med."},{"key":"BF01991240_CR10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/art.1780280511","volume":"28","author":"F. O'sullivan","year":"1985","unstructured":"F. O'sullivan, H. G. Fassbender, S. Gay and W. Koopman,Ethiopathogenesis of the rheumatoid arthritis-like disease in MRL\/lpr mice. I. The histomorphologic basis of joint destruction. Arth. Rheum.28, 529\u2013536 (1985).","journal-title":"Arth. Rheum."},{"key":"BF01991240_CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/03009748609098212","volume":"15","author":"R. Luukkainen","year":"1986","unstructured":"R. Luukkainen, R. Talonen, E. Uksila and K. Auerma,Relationship between some joint fluid, blood and serum variables and radiological destruction in knee joints in arthritic patients. Scand. J. Rheumatol.15, 399\u2013406 (1986).","journal-title":"Scand. J. Rheumatol."},{"key":"BF01991240_CR12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/art.1780310404","volume":"31","author":"N. Miyasaka","year":"1988","unstructured":"N. Miyasaka et al.,Augmented IL-1 production and HLA-DR expression in the synovium of rheumatoid patients: Possible involvement in joint destruction. Arth. Rheum.31, 480\u2013486 (1988).","journal-title":"Arth. Rheum."},{"key":"BF01991240_CR13","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.4049\/jimmunol.146.10.3523","volume":"146","author":"W. Almawi","year":"1991","unstructured":"W. Almawi et al.,Abrogation of glucocorticosteroid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-\u03b4. J. Immunol.146, 3523\u20133527 (1991).","journal-title":"J. Immunol."},{"key":"BF01991240_CR14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0952-7915(89)90094-0","volume":"2","author":"M. L. Lohman-Matthes","year":"1989","unstructured":"M. L. Lohman-Matthes,Interaction of macrophages and cytokines. Curr. Opin. Immunol.2, 33\u201338 (1989).","journal-title":"Curr. Opin. Immunol."},{"key":"BF01991240_CR15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/1043-4666(91)90501-4","volume":"3","author":"J. Marcinkiewicz","year":"1991","unstructured":"J. Marcinkiewicz,In vitro cytokine release by activated murine peritoneal macrophages: Role of prostaglandins in the differential regulation of TNF\u03b1, IL-1, and IL-6. Cytokine3, 327\u2013332 (1991).","journal-title":"Cytokine"},{"key":"BF01991240_CR16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0006-8993(91)90771-M","volume":"558","author":"S. Ohgo","year":"1991","unstructured":"S. Ohgo, K. Nakatsuru, E. Ishikawa and S. Matsukura,IL-1 stimulates the release of CRF from superfused rat hypothalamo-neurohypophyseal complexes independently of the histaminergic mechanisms. Brain Res.558, 217\u2013223 (1991).","journal-title":"Brain Res."},{"key":"BF01991240_CR17","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood.V77.8.1627.1627","volume":"77","author":"C. A. Dinarello","year":"1991","unstructured":"C. A. Dinarello,IL-1 and IL-1 antagonism. Blood77, 1627\u20131652 (1991).","journal-title":"Blood"},{"key":"BF01991240_CR18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1084\/jem.173.4.931","volume":"173","author":"K. W. McIntyre","year":"1991","unstructured":"K. W. McIntyre et al.,Inhibition of IL-1 binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody. J. Exp. Med.173, 931\u2013939 (1991).","journal-title":"J. Exp. Med."},{"key":"BF01991240_CR19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0014-4827(91)90387-A","volume":"195","author":"A. Harvey","year":"1991","unstructured":"A. Harvey, P. Hrubey and S. Chandrasekhar,TGF\u03b2 inhibition of IL-1 activity involves down-regulation of IL-1 receptors on chondrocytes. Exp. Cell Res.195, 376\u2013385 (1991).","journal-title":"Exp. Cell Res."},{"key":"BF01991240_CR20","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/eji.1830210708","volume":"21","author":"M. Turner","year":"1991","unstructured":"M. Turner et al.,Induction of IL-1 receptor antagonist protein by TGF\u03b2. Eur. J. Immunol.21, 1635\u20131639 (1991).","journal-title":"Eur. J. Immunol."},{"key":"BF01991240_CR21","first-page":"344","volume":"72","author":"P. Hart","year":"1991","unstructured":"P. Hart, R. Cooper and J. Finlay-Jones,IL-4 suppresses IL-1\u03b2, TNF\u03b1 and PGE 2 production by human peritoneal macrophages. Immunology72, 344\u2013349 (1991).","journal-title":"Immunology"},{"key":"BF01991240_CR22","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.4049\/jimmunol.146.10.3431","volume":"146","author":"R. Donnelly","year":"1991","unstructured":"R. Donnelly, M. Fenton, J. Kaufman and T. Gerrard,IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4. J. Immunol.146, 3431\u20133436 (1991).","journal-title":"J. Immunol."},{"key":"BF01991240_CR23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01993304","volume":"34","author":"G. Bandera","year":"1991","unstructured":"G. Bandera, H. Georgescu, C. Lin and C. Evans,Synovial activation of chondrocytes: Evidence for complex cytokine interactions. Agents and Actions34, 285\u2013288 (1991).","journal-title":"Agents and Actions"},{"issue":"Suppl.","key":"BF01991240_CR24","first-page":"90","volume":"31","author":"O. Otterness","year":"1988","unstructured":"O. Otterness, M. Bliven, J. Downs and D. Hanson,Effects of CP-66248 on IL-1 synthesis by murine peritoneal macrophages. Arth. Rheum.31, (Suppl.), 90 (1988).","journal-title":"Arth. Rheum."},{"key":"BF01991240_CR25","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0192-0561(88)90007-0","volume":"10","author":"J. Lee","year":"1988","unstructured":"J. Lee, D. Griswold, B. Votta and N. Hanna,Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002. Int. J. Immunopharmacol.10, 835\u2013843 (1988).","journal-title":"Int. J. Immunopharmacol."},{"key":"BF01991240_CR26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/BF01966299","volume":"30","author":"J. Schnyder","year":"1990","unstructured":"J. Schnyder, P. Bollinger and T. Payne,Inhibition of IL-1 release by IX 207-887. Agents and Actions30, 350\u2013362 (1990).","journal-title":"Agents and Actions"},{"key":"BF01991240_CR27","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1021\/jm00112a046","volume":"34","author":"M. Tanaka","year":"1991","unstructured":"M. Tanaka et al.,3-(5 Alkyl-4-hydroxy-3-methoxy-1-naphtalenyl)-2-methyl-2-propenoic acids as orally active inhibitors of IL-1 generation. J. Med. Chem.34, 2647\u20132649 (1991).","journal-title":"J. Med. Chem."}],"container-title":["Agents and Actions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01991240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01991240\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01991240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T01:25:17Z","timestamp":1683163517000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01991240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["BF01991240"],"URL":"https:\/\/doi.org\/10.1007\/bf01991240","relation":{},"ISSN":["0065-4299","1420-908X"],"issn-type":[{"value":"0065-4299","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}